DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment wkd and Tbc1d12

DIOPT Version :9

Sequence 1:	NP_650089.1	Gene:	wkd / 41390	FlyBaseID:	FBgn0037917	Length:	363	Species:	Drosophila melanogaster
Sequence 2:	NP_666064.3	Gene:	Tbc1d12 / 209478	MGIID:	2384803	Length:	698	Species:	Mus musculus

Alignment Length:	305	Identity:	77/305 - (25%)
Similarity:	132/305 - (43%)	Gaps:	61/305 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 KPKEPLSKAQIIAREKKWL-YMIDNWSIYMSKNYKKIRDRCRKGIPKSVRPKAWFYLSGAYLLKK 98
            |.:|.::.|.:|     |: .::.||.:..|.  :::|:...:|:|.|||.|.|....|..|  .
Mouse   371 KQEESIASAMVI-----WINEILPNWEVMRST--RRVRELWWQGLPPSVRGKVWSLAVGNEL--N 426

  Fly    99 KNPNVYNELLEK------------PGNPT----------TIEEIKKDKHRQFPFHEMFLDEQKVG 141
            ..|.:|...|.:            ..|.|          ::|.||.|..|.||...:|   ||.|
Mouse   427 ITPELYEIFLSRAKERWKSFSESSSENDTEGLSVADREASLELIKLDISRTFPSLYIF---QKGG 488

  Fly   142 QIE--LFNVLKAYSIYNPKVGFCQAQAPIAAFLLMHLPAEDAFWVFVSVCDVYLQ-DYFIPGLEV 203
            ...  |.::|.||:.|.|.||:.|..:.|||.|:::|...|||..|.::.:...| .:|.....:
Mouse   489 PYHDVLHSILGAYTCYRPDVGYVQGMSFIAAVLILNLEEADAFIAFANLLNKPCQLAFFRVDHSM 553

  Fly   204 IQNDAGILEGLLKKTCPPVYRHLQKHKVEPLLYMTDWFLCAMTRTLPWETLLRVWDCFLAEGIRV 268
            :.......|...::....::.|.:.:.:.|.:|:.||.....:::||.:...||||.|..:|...
Mouse   554 MLKYFATFEVFFEENLSKLFLHFKSYNLTPDIYLIDWIFTLYSKSLPLDLACRVWDVFCRDGEEF 618

  Fly   269 IFKVALVIIGASLSRHKVRKTCTGLCETLAVLRSPEEHIVEEEFI 313
            :|:                   ||    |.:||..|:.:::.:||
Mouse   619 LFR-------------------TG----LGILRLYEDILLQMDFI 640

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wkd	NP_650089.1	RabGAP-TBC	114..277	CDD:366170	47/175 (27%)
Tbc1d12	NP_666064.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..59
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	93..123
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	158..236
		COG5210	304..639	CDD:227535	75/302 (25%)
		RabGAP-TBC	468..635	CDD:278964	52/192 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810