DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment wkd and tbc-19

DIOPT Version :9

Sequence 1:	NP_650089.1	Gene:	wkd / 41390	FlyBaseID:	FBgn0037917	Length:	363	Species:	Drosophila melanogaster
Sequence 2:	NP_510336.3	Gene:	tbc-19 / 181511	WormBaseID:	WBGene00007849	Length:	1333	Species:	Caenorhabditis elegans

Alignment Length:	348	Identity:	94/348 - (27%)
Similarity:	162/348 - (46%)	Gaps:	46/348 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 NGFYGGFQRTDKPKEPLSKAQIIAREKKWLYMIDNWSIYMSKN-----YKKIRDRCRKGIPKSVR 83
            |.||....::             |.|.|:     ||..::.:|     ..:.:..||||||.|:|
Worm   411 NHFYANRSKS-------------ASEHKY-----NWKRFLEENDFIDLTPETKIMCRKGIPNSLR 457

  Fly    84 PKAWFYLSGAYLLKKKNPNVYNELL------------EKPGNPTTIEEIKKDKHRQFPFHEMFLD 136
            ...|..|....:...|  |||.:..            ||..:....::|..|..|..|.:..|:.
Worm   458 ATVWKILINQQVEDLK--NVYGKYYYRNLCNIQGGEDEKTYSDVHQKQINLDLLRTMPNNVHFMS 520

  Fly   137 EQKVGQIELFNVLKAYSIYNPKVGFCQAQAPIAAFLLMHLPAEDAFWVFVSVCDVYL-QDYFIPG 200
            ....|..:|..||.|:.::|.::|:||....:||..|:.:..|||||..::|.:.|. :.||...
Worm   521 ANSKGVTQLLQVLHAFCLHNSQIGYCQGMNFLAATALLFVGPEDAFWFLIAVTERYFDKTYFDSN 585

  Fly   201 LEVIQNDAGILEGLLKKTCPPVYRHLQKHKVEPLLYMTDWFLCAMTRTLPWETLLRVWDCFLAEG 265
            |...|.|..:|:|||:...|.:.:||:...::...:..:||:......:|:.||||:|||||.||
Worm   586 LTGAQADQEVLKGLLEVQHPKIMKHLKSLDIDVASFTLNWFISLFFDAVPFNTLLRIWDCFLLEG 650

  Fly   266 IRVIFKVALVIIGASLSRHKVRKTCTGLCETLAVLRSPEEHIVEEEFIINNMMRL-----NLRVE 325
            .:|:|:.|:|:||........|....|:   :.|.::..:...:||.|:|...|:     .:.::
Worm   651 PKVLFRFAIVLIGKHEEEIISRGDAIGI---MRVSKAATKLAFDEEAIVNMAFRIPNLPTRIELK 712

  Fly   326 DFQIEHTRQKARRAKQKAQQEAE 348
            :.|:::....|.|.::|.::..|
Worm   713 NMQLQYVNLLAERLEKKMRRANE 735

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wkd	NP_650089.1	RabGAP-TBC	114..277	CDD:366170	54/163 (33%)
tbc-19	NP_510336.3	PH-like	13..112	CDD:302622
		PH	16..110	CDD:278594
		TBC	448..670	CDD:214540	72/223 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810