DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment wkd and tbc-18

DIOPT Version :9

Sequence 1:	NP_650089.1	Gene:	wkd / 41390	FlyBaseID:	FBgn0037917	Length:	363	Species:	Drosophila melanogaster
Sequence 2:	NP_509421.2	Gene:	tbc-18 / 181091	WormBaseID:	WBGene00018281	Length:	826	Species:	Caenorhabditis elegans

Alignment Length:	345	Identity:	82/345 - (23%)
Similarity:	135/345 - (39%)	Gaps:	45/345 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 GFQRTDKPKEP---------------------------LSKAQIIAREKKWLYMIDN--WSIYMS 64
            ||::.|...:|                           :|..|.:.:|.|     |:  ||..:.
Worm    75 GFRKQDDDHDPNLGDEEETSSAKHLSEPLENSTHKLKLISYLQDVHKEVK-----DDVLWSHILG 134

  Fly    65 KNYKKIRDRCRK-----GIPKSVRPKAWFYLSGAYLLKKKNPNVYNELLEK--PGNPTTIEEIKK 122
            ...|  .||..:     |||.|:||..|..||||...:|.....|..:|::  ...|:...:|::
Worm   135 PELK--TDRFEELLKEGGIPHSMRPFLWPRLSGATKKQKDAKYTYESVLQQCAQDKPSIGVQIER 197

  Fly   123 DKHRQFPFHEMFLDEQKVGQIELFNVLKAYSIYNPKVGFCQAQAPIAAFLLMHLPAEDAFWVFVS 187
            |..|..|.:..|..:...|...|..:||..:...|.:|:||....|.|.||::...|..||:..:
Worm   198 DLLRTLPNNICFWKKNSEGIEALRRILKCVAFIYPDLGYCQGMGVIVATLLLYCSEETTFWMMTA 262

  Fly   188 VC-DVYLQDYFIPGLEVIQNDAGILEGLLKKTCPPVYRHLQKHKVEPLLYMTDWFLCAMTRTLPW 251
            :. |:...:::...|..:|.|..:...|:|...|.:.:.|:.::||..|....|.|.........
Worm   263 LIEDILPPNFYTQTLLGLQADERVSRHLMKCHVPDLNKALEDYEVEVSLLTVSWLLTLFGSVFRT 327

  Fly   252 ETLLRVWDCFLAEGIRVIFKVALVIIGASLSR-HKVRKTCTGLCETLAVLRSPEEHIVEEEFIIN 315
            ..:|||||.....|...||:|.:.|:...... .::.:|.....:....|......:.|.|.:|.
Worm   328 RVMLRVWDFIFYSGGVNIFRVIISILKMKEQEIVEIAETTQSSADIFTALSQLPASVTEVEKVIE 392

  Fly   316 NMMRLNLRVEDFQIEHTRQK 335
            .|......:.|..|...|:|
Worm   393 YMGSFEFTITDHLIAELRKK 412

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wkd	NP_650089.1	RabGAP-TBC	114..277	CDD:366170	43/163 (26%)
tbc-18	NP_509421.2	TBC	148..361	CDD:214540	58/212 (27%)
		SH3_SGSM3	528..580	CDD:212747
		RUN	607..765	CDD:280855
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R540
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.840