DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment wkd and tbc-11

DIOPT Version :9

Sequence 1:	NP_650089.1	Gene:	wkd / 41390	FlyBaseID:	FBgn0037917	Length:	363	Species:	Drosophila melanogaster
Sequence 2:	NP_508178.2	Gene:	tbc-11 / 180444	WormBaseID:	WBGene00018075	Length:	934	Species:	Caenorhabditis elegans

Alignment Length:	395	Identity:	106/395 - (26%)
Similarity:	169/395 - (42%)	Gaps:	64/395 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 GFQRTDKPKEPLSKAQIIAREKK------WLYMIDNWSIYMSKNYKKIRDRCRKGIPKSVRPKAW 87
            |...:|..:..||.:..:::|.|      |..:|:||. ..|...:||.:....|||..:|.:.|
Worm   369 GDDESDCDEPLLSGSGKVSQECKEEHLEMWDQLIENWD-QQSDRPQKISELVLDGIPDKLRGRVW 432

  Fly    88 FYLSGAYLLKKKNPNV---YNELLEKPGNPTTIEEIKKDKHRQFPFHEMFLDEQKVGQIELFNVL 149
            ..||...:|....|::   |:..|.:|.....:  |.:|.||.||.|:.|.:.|..||..|:.:.
Worm   433 QLLSNVRILAIDQPDLVEKYHIFLSQPCPSEQV--IMRDIHRTFPAHDYFKESQGKGQQSLYKIS 495

  Fly   150 KAYSIYNPKVGFCQAQAPIAAFLLMHLPAEDAFWVFVSVCDVY-LQDYFIPGLEVIQNDAGILEG 213
            |.||:|:.:|.:||..:.:||.||:|:|.|.||...|.:...| |:|.|..|.:.:......|..
Worm   496 KVYSLYDEEVSYCQGLSFLAASLLLHMPEEQAFCTLVKIMFNYGLRDLFKLGFDNLHLRFFQLTA 560

  Fly   214 LLKKTCPPVYRHLQKHKVEPLLYMTDWFLCAMTRTLPWETLLRVWDCFLAEGIRVIFKVALVIIG 278
            |||...|.:..||:...:|..:|.:.|||...|...|.:.:..:.|.||::|:..||.::|.::.
Worm   561 LLKDYIPDLSHHLEHIGIETHMYASQWFLTLFTAKFPLQMVFFILDLFLSQGMNTIFHISLALLD 625

  Fly   279 -------------------ASLSRHKVRKTCTGLC------------ETLAVLRSPEEHIVE--- 309
                               .||.| |.|...:..|            ..|.|..:..:.|.|
Worm   626 DAKTDLLQLDFEGTLKYFRVSLPR-KYRTEASTKCLIHKAVKFRLNHSKLEVYENEYKRIKELER 689

  Fly   310 --EEFIIN----------NMMRLNLRVEDFQIEHTRQK--ARRAKQKAQQEAESSGSGNGH--RR 358
              |:.::.          |.:||....:|...|....|  .||....|:.:.|:|.:....  |:
Worm   690 ENEDPVLRMEKEIGRHQANTLRLERENDDLAHELVTSKIELRRKLDVAEDQIETSANAIERLTRQ 754

  Fly   359 NMPTL 363
            ||..|
Worm   755 NMDIL 759

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wkd	NP_650089.1	RabGAP-TBC	114..277	CDD:366170	55/163 (34%)
tbc-11	NP_508178.2	PH-like	11..147	CDD:388408
		DUF3694	183..293	CDD:372133
		TBC	419..632	CDD:214540	67/214 (31%)
		Smc	<697..>901	CDD:224117	15/63 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910