DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment wkd and tbc-8

DIOPT Version :9

Sequence 1:	NP_650089.1	Gene:	wkd / 41390	FlyBaseID:	FBgn0037917	Length:	363	Species:	Drosophila melanogaster
Sequence 2:	NP_001255072.1	Gene:	tbc-8 / 176454	WormBaseID:	WBGene00008018	Length:	913	Species:	Caenorhabditis elegans

Alignment Length:	284	Identity:	55/284 - (19%)
Similarity:	98/284 - (34%)	Gaps:	73/284 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 KKIRDRCRKGI-PKSVRPKAWFYLSGAY-----------------------------LLKKKNPN 102
            |::..|..:|| .|.||..||.||.|.:                             .:::::..
Worm   587 KRVYWRGIEGINTKEVRRMAWPYLLGLFEWNESPESRLEQFTSQYWQDIEEWRVLEAEVRRRDEE 651

  Fly   103 VYN----------------ELLEKPGNPT----------------TIEEIKKDKHRQFPFHEMFL 135
            .:.                ::.|.|..||                .:..|.||..| ...:.||.
Worm   652 AFRAARARKAASPVREESCDVFEDPNEPTCSQHYDRENLITLFRANLHRIDKDVER-CDRNLMFF 715

  Fly   136 DEQKVGQIELFNVLKAYSIYNPKVGFCQAQAPIAAFLLMHLPAEDAFWVFVSVCDVYLQDYF--I 198
             ..|.....|..|:..|...|.:.|:.|....:.|.||:....|.......|:..:..:..|  .
Worm   716 -SNKDNLESLRRVMYTYVRRNLEEGYTQGMCDLLAPLLVTFEDEALTLECFSLLMLRQRGKFPQR 779

  Fly   199 PGL-EVIQNDAGILEGLLKKTCPPVYRHLQK-HKVEPLLYMTDWFLCAMTRTLPWETLLRVWD-C 260
            ||: :.:.|    |..|::...|.:|..:.. ...:.|.:...|||....|.|.:|...:||: .
Worm   780 PGMSKCLLN----LRSLIQVVDPQIYALISDIDYAQALSFAFRWFLLDFKRELSYECTYKVWEVI 840

  Fly   261 FLAEGIRVIFKVALVIIGASLSRH 284
            :.|:.:|:....|:....|:::.:
Worm   841 WAAQRLRITDDFAIFFGLATITNY 864

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wkd	NP_650089.1	RabGAP-TBC	114..277	CDD:366170	40/183 (22%)
tbc-8	NP_001255072.1	RUN	177..237	CDD:214736
		PH_RUTBC	299..467	CDD:275431
		TBC	670..869	CDD:214540	43/201 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910