DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment wkd and tbc-14

DIOPT Version :9

Sequence 1:	NP_650089.1	Gene:	wkd / 41390	FlyBaseID:	FBgn0037917	Length:	363	Species:	Drosophila melanogaster
Sequence 2:	NP_001317776.1	Gene:	tbc-14 / 174986	WormBaseID:	WBGene00008444	Length:	630	Species:	Caenorhabditis elegans

Alignment Length:	389	Identity:	76/389 - (19%)
Similarity:	144/389 - (37%)	Gaps:	79/389 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 DRNGFYGGFQRTDKPKEPLSKAQIIAREKKW-LYMIDNWSIYMSKNYKKIRDRCRKGIPKSVRPK 85
            |..|.:....:.:.|..|....::...:..| .:.:.|.|....|.:....:..|.|:...:|.:
Worm   267 DAAGEFEVVTQLELPPRPEIYRELPVSKDLWNSFKLSNGSYDPMKLHHLKMNVFRGGLNAELRKE 331

  Fly    86 AWFYLSG---------------AYLLKKKNPNVYNELLEKPGNPTTIEE------------IKKD 123
            ||..|.|               |.|.|:     |..:.::..:.|..:|            ::||
Worm   332 AWKCLLGYRQWHESDTDFQTRRAELAKQ-----YENMKKQWMSVTEDQEKRFTKFVKRKSLVEKD 391

  Fly   124 ---KHRQFPFHEMFLDEQKVGQIELFNVLKAYSIYNPKVGFCQAQAPIAAFLLMHLPAE-DAFWV 184
               ..|..||   |..:..|..:.|.|||..|.:||..:|:.|..:..|:.||..:..| |.||.
Worm   392 VARTDRTVPF---FQGDDNVNLVHLHNVLMTYVMYNFDLGYVQGMSDFASPLLFVMKDEVDTFWC 453

  Fly   185 FVSVCDVYLQDYFIPGLEVIQNDAGILEGLLKKTCPPVYRHLQKHKVEPLLYMTDWFLCAMTRTL 249
            ||.:.:: .|..|......|:.....|..|:....|.:..:|:..|.:.:.:...|.|....|..
Worm   454 FVGLMEL-TQKNFETDQAFIKLQMNQLRDLVMIINPKLANYLESEKSDDMYFCFRWVLVWFKREF 517

  Fly   250 PWETLLRVWDCFLAEGIRVIFKVALVIIGASLSRHKVRKTCTGLCETLAVLRSPEEHIVEEEFII 314
            .:....::|:...:              |....|..:.     :|  :|:|.|....|::.:|.:
Worm   518 SFLDTCKLWEVLWS--------------GQPCPRFLLL-----IC--VAILDSQTNIIIDNQFGL 561

  Fly   315 NNMMR------LNLRVEDF---------QIEHTRQK--ARRAKQKAQQEAESSGSGNGHRRNMP 361
            ..:::      ::|:|::.         |:..::.|  |...:.....|:..|.|.|...::.|
Worm   562 TEILKHINDLSMHLKVDEILTAAEAIFHQLSASQNKLPAHICQYLNIGESAVSSSNNSPSKSDP 625

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wkd	NP_650089.1	RabGAP-TBC	114..277	CDD:366170	39/178 (22%)
tbc-14	NP_001317776.1	DUF3548	51..197	CDD:371881
tbc-14	NP_001317776.1	TBC	320..555	CDD:214540	56/264 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810