DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment wkd and SGSM1

DIOPT Version :9

Sequence 1:	NP_650089.1	Gene:	wkd / 41390	FlyBaseID:	FBgn0037917	Length:	363	Species:	Drosophila melanogaster
Sequence 2:	NP_001035037.1	Gene:	SGSM1 / 129049	HGNCID:	29410	Length:	1148	Species:	Homo sapiens

Alignment Length:	149	Identity:	32/149 - (21%)
Similarity:	59/149 - (39%)	Gaps:	26/149 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   144 ELFNVLKAYSIYNPKVGFCQAQAPIAAFLLMHLPAED-AFWVFVSVCDVYLQDY---------FI 198
            :|.|::.:|...:.::|:.|....:.|.||:.|..|. ||..|..:.....|::         |.
Human   960 KLRNIMCSYIWQHIEIGYVQGMCDLLAPLLVILDDEALAFSCFTELMKRMNQNFPHGGAMDTHFA 1024

  Fly   199 PGLEVIQ-NDAGILEGLLKKTCPPVYRHLQKHKVEPLLYMTDWFLCAMTRTLPWETLLRVWDCFL 262
            ....:|| .|:.:.| |:.:...  |.|        ..:...|||....|.|.::.:..||:...
Human  1025 NMRSLIQILDSELFE-LMHQNGD--YTH--------FYFCYRWFLLDFKRELVYDDVFLVWETIW 1078

  Fly   263 A----EGIRVIFKVALVII 277
            |    .....:..:||.::
Human  1079 AAKHVSSAHYVLFIALALV 1097

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wkd	NP_650089.1	RabGAP-TBC	114..277	CDD:366170	32/147 (22%)
SGSM1	NP_001035037.1	RUN	44..188	CDD:280855
		PH_RUTBC	254..425	CDD:275431
		Important for interaction with RAB9A and RAB9B. /evidence=ECO:0000250\|UniProtKB:Q8BPQ7	256..297
		Required for interaction with RAP family members	301..350
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	377..411
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	700..830
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	871..894
		TBC	<936..1105	CDD:214540	32/149 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900