Protein Alignment wkd and EVI5L

DIOPT Version :10

• Sequence 1: NP_650089.1
• Gene: wkd / 41390
• FlyBaseID: FBgn0037917
• Length: 363
• Species: Drosophila melanogaster
• Sequence 2: NP_001153416.1
• Gene: EVI5L / 115704
• HGNCID: 30464
• Length: 805
• Species: Homo sapiens
• Alignment Length: 326
• Identity: 98/326 - (30%)
• Similarity: 155/326 - (47%)
• Gaps: 39/326 - (11%)

  Fly    52 WLYMIDNWSIYMSKNYKKIRDRCRKGIPKSVRPKAWFYLSGAYLLKKKNPNVYNELLEKPGNPTT 116
            |..:.:.|..:..:..|.:::..|||||...|...|..|..|..:..||.  |:||| |..:|..
Human    90 WGRIANEWEEWRRRKEKLLKELIRKGIPHHFRAIVWQLLCSATDMPVKNQ--YSELL-KMSSPCE 151

  Fly   117 IEEIKKDKHRQFPFHEMFLDEQKVGQIELFNVLKAYSIYNPKVGFCQAQAPIAAFLLMHLPAEDA 181
             :.|::|..|.:|.||.|..:..:||..||||:||||:.:.:||:||..|.|...|||.:|.|:|
Human   152 -KLIRRDIARTYPEHEFFKGQDSLGQEVLFNVMKAYSLVDREVGYCQGSAFIVGLLLMQMPEEEA 215

  Fly   182 FWVFVSVCDVY-LQDYFIP-----GLEVIQNDAGILEGLLKKTCPPVYRHLQKHKVEPLLYMTDW 240
            |.|||.:...| |::.|.|     ||.:.|     .|.:|::..|.:..|.:.......:|.:.|
Human   216 FCVFVRLMQEYRLRELFKPSMAELGLCIYQ-----FEYMLQEQLPDLNTHFRSQSFHTSMYASSW 275

  Fly   241 FLCAMTRTLPWETLLRVWDCFLAEGIRVIFKVALVII-------------GASLSRHKVRKTCTG 292
            ||.....|.|.....||:|.|:.||:.::|:|.|.::             |.|....:|......
Human   276 FLTLFLTTFPLPVATRVFDIFMYEGLEIVFRVGLALLQVNQAELMQLDMEGMSQYFQRVIPHQFD 340

  Fly   293 LCETLAVLR------SPEE-HIVEEEFIINNMMRLNLRVEDFQIEHTRQKARRAKQKAQQ-EAES 349
            .|....||:      :|:: ..:|:|:.   .|:.....|..:|:..|.:.|..||:.:. |.||
Human   341 SCPDKLVLKAYQVKYNPKKMKRLEKEYA---AMKSKEMEEQIEIKRLRTENRLLKQRIETLEKES 402

  Fly   350 S 350
            :
Human   403 A 403

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
wkd	NP_650089.1	TBC	74..278	CDD:214540	76/222 (34%)
EVI5L	NP_001153416.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..36
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	49..75
		TBC	112..320	CDD:214540	76/216 (35%)
		Smc	<363..>762	CDD:440809	12/44 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	777..805