DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment wkd and Tbc1d10a

DIOPT Version :9

Sequence 1:	NP_650089.1	Gene:	wkd / 41390	FlyBaseID:	FBgn0037917	Length:	363	Species:	Drosophila melanogaster
Sequence 2:	NP_598784.1	Gene:	Tbc1d10a / 103724	MGIID:	2144164	Length:	500	Species:	Mus musculus

Alignment Length:	328	Identity:	151/328 - (46%)
Similarity:	212/328 - (64%)	Gaps:	0/328 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 DRNGFYGGFQRTDKPKEPLSKAQIIAREKKWLYMIDNWSIYMSKNYKKIRDRCRKGIPKSVRPKA 86
            |:.||..|.|..:...|.:....:..||.|||.|::||..:|:|.:||||.||:||||.|:|.:|
Mouse    56 DKFGFIVGSQGAEGALEEVPLEVLRQRESKWLDMLNNWDKWMAKKHKKIRLRCQKGIPPSLRGRA 120

  Fly    87 WFYLSGAYLLKKKNPNVYNELLEKPGNPTTIEEIKKDKHRQFPFHEMFLDEQKVGQIELFNVLKA 151
            |.||||..:..::||..::||...||:|..::.|::|.||||||||||:.....||.:||.||||
Mouse   121 WQYLSGGKVKLQQNPGKFDELDMSPGDPKWLDVIERDLHRQFPFHEMFVSRGGHGQQDLFRVLKA 185

  Fly   152 YSIYNPKVGFCQAQAPIAAFLLMHLPAEDAFWVFVSVCDVYLQDYFIPGLEVIQNDAGILEGLLK 216
            |::|.|:.|:|||||||||.||||:|||.|||..|.||:.||..|:...||.||.|..||..||:
Mouse   186 YTLYRPEEGYCQAQAPIAAVLLMHMPAEQAFWCLVQVCEKYLPGYYSEKLEAIQLDGEILFSLLQ 250

  Fly   217 KTCPPVYRHLQKHKVEPLLYMTDWFLCAMTRTLPWETLLRVWDCFLAEGIRVIFKVALVIIGASL 281
            |..|..::||.:.|::||||||:||:||..|||||.::|||||.|..||:::||:|.||::..:|
Mouse   251 KVSPVAHKHLSRQKIDPLLYMTEWFMCAFARTLPWSSVLRVWDMFFCEGVKIIFRVGLVLLKHAL 315

  Fly   282 SRHKVRKTCTGLCETLAVLRSPEEHIVEEEFIINNMMRLNLRVEDFQIEHTRQKARRAKQKAQQE 346
            ...:..|.|.|..||:..|||....|::|.|::..::.|.:.....:.||..|..|..:.:.:.|
Mouse   316 GSPEKLKACQGQYETIEQLRSLSPKIMQEAFLVQEVIELPVTERQIEREHLIQLRRWQETRGELE 380

  Fly   347 AES 349
            ..|
Mouse   381 CRS 383

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wkd	NP_650089.1	RabGAP-TBC	114..277	CDD:366170	92/162 (57%)
Tbc1d10a	NP_598784.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..45
		TBC	110..313	CDD:214540	110/202 (54%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	396..415
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	420..500
		Binding to the PDZ domain of EBP50. /evidence=ECO:0000250	497..500
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	236	1.000	Domainoid score	I2331
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	314	1.000	Inparanoid score	I2548
Isobase	1	0.950	-	0	Normalized mean entropy	S2353
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D309166at33208
OrthoFinder	1	1.000	-	-		FOG0001498
OrthoInspector	1	1.000	-	-		otm43269
orthoMCL	1	0.900	-	-		OOG6_104218
Panther	1	1.100	-	-	O	PTHR22957
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R540
SonicParanoid	1	1.000	-	-		X1223
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.950