DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment wkd and sgsm3

DIOPT Version :9

Sequence 1:	NP_650089.1	Gene:	wkd / 41390	FlyBaseID:	FBgn0037917	Length:	363	Species:	Drosophila melanogaster
Sequence 2:	NP_001123837.1	Gene:	sgsm3 / 100170594	XenbaseID:	XB-GENE-965522	Length:	753	Species:	Xenopus tropicalis

Alignment Length:	267	Identity:	79/267 - (29%)
Similarity:	128/267 - (47%)	Gaps:	29/267 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 KIRDRCRKGIPKSVRPKAWFYLSGAYLLKKKNPNVYNELLEKPGNPTTI--EEIKKDKHRQFPFH 131
            |:|.....|||.|:||:.|..||||...|:.:...|.:::....|..|:  ::|:||..|..|.:
Frog   107 KLRSLVLAGIPHSMRPQLWMRLSGALQKKQNSEMTYKDIVRNSSNDDTLAAKQIEKDLLRTMPSN 171

  Fly   132 EMFLDEQKVGQIELFNVLKAYSIYNPKVGFCQAQAPIAAFLLMHLPAEDAFWVFVSVC-DVYLQD 195
            ..|.:.|.||...|..||:..:...|.:|:||....:||.||:.|..|||||:..::. |:....
Frog   172 ACFSNLQSVGVPRLRRVLRGLAWLYPDIGYCQGTGMVAACLLLFLEEEDAFWMMAAIVEDLVPVS 236

  Fly   196 YFIPGLEVIQNDAGILEGLLKKTCPPVYRHLQKHKVEPLLYMTDWFLCAMTRTLPWETLLRVWDC 260
            ||...|..:|.|..:|..|:.:..|.:.:.||:|.:|..|....|||.|....:..:.|||:||.
Frog   237 YFNTTLVGVQTDQRVLRHLIVQYLPRLDKLLQEHDIELSLITLHWFLTAFASVVHIKLLLRIWDF 301

  Fly   261 FLAEGIRVIFKVALVIIGASLSRHKVRKTCTGLCETLAVLRSPEEHIVEEE---FIINNMMRLNL 322
            |..:|..|:|:.                       ||.:|:..||.:::.|   .|.|.:..:..
Frog   302 FFYQGSLVLFQT-----------------------TLGMLKMKEEELIQSENSASIFNTLSDIPS 343

  Fly   323 RVEDFQI 329
            ::|:..:
Frog   344 QIEEADV 350

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wkd	NP_650089.1	RabGAP-TBC	114..277	CDD:366170	54/165 (33%)
sgsm3	NP_001123837.1	TBC	115..326	CDD:214540	73/233 (31%)
		SH3_SGSM3	486..538	CDD:212747
		RUN	565..716	CDD:367169
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R540
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940