DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment wkd and tbc1d9b

DIOPT Version :9

Sequence 1:	NP_650089.1	Gene:	wkd / 41390	FlyBaseID:	FBgn0037917	Length:	363	Species:	Drosophila melanogaster
Sequence 2:	NP_001107313.1	Gene:	tbc1d9b / 100135104	XenbaseID:	XB-GENE-989754	Length:	1259	Species:	Xenopus tropicalis

Alignment Length:	334	Identity:	92/334 - (27%)
Similarity:	161/334 - (48%)	Gaps:	39/334 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 ATAPRSLDTISLCSTVSSCPDRNGFYGGFQRTDKPKEPLSKAQIIARE------KKW---LYMID 57
            ||.|....:..:..|.|: |..||       :|.|.......::..||      .||   ....:
Frog   423 ATNPSPSSSTDVSPTFST-PQNNG-------SDAPTASHGLLKLFQREITEDMKPKWDKEKMKEE 479

  Fly    58 NWSIYMSK--------NYKKIRDRCRKGIPKSVRPKAWFYLSGAYLLKKKNPNVYNELLEKPGNP 114
            :|:|:..:        ...|.|:...||||:::|.:.|...|||......:|..|.:|:||....
Frog   480 SWNIHFLEYGRGMCMYRTSKTRELVLKGIPENLRGELWLLFSGASNEMVTHPGYYADLVEKSMGR 544

  Fly   115 TTI--EEIKKDKHRQFPFHEMFLDEQKVGQIELFNVLKAYSIYNPKVGFCQAQAPIAAFLLMHLP 177
            ..:  :||::|.||..|.|..|.:|  :|...|..||.||:..||.:|:|||...:.:.||::..
Frog   545 CNLATDEIERDLHRSMPEHPAFQNE--LGIAALRRVLTAYAFRNPNIGYCQAMNIVTSVLLLYCN 607

  Fly   178 AEDAFWVFVSVCDVYLQDYF---IPGLEVIQNDAGILEGLLKKTCPPVYRHLQKHKVEPLLYMTD 239
            .|:|||:.||:|:..|.||:   :.|..|   |.|:.|.|.:...|.:...:|:..|...:.::
Frog   608 EEEAFWLLVSLCEHMLPDYYNTRVVGALV---DQGVFEELTRLYLPQLSEKMQELGVISTISLS- 668

  Fly   240 WFLCAMTRTLPWETLLRVWDCFLAEGIRVIFKVALVIIGASLSRHKVRKTCTGLCETLAVLRSPE 304
            |||......:|:|:.:.|.|||..|||::|.:::|.::.|::   :....|....|.:.:|....
Frog   669 WFLTLFLSVMPFESAVVVVDCFFFEGIKLILQLSLAVLEANM---ESLMNCMDEGEAMTILGRYL 730

  Fly   305 EHIVEEEFI 313
            ::::.::.:
Frog   731 DNVLNKQSV 739

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wkd	NP_650089.1	RabGAP-TBC	114..277	CDD:366170	56/167 (34%)
tbc1d9b	NP_001107313.1	PH-GRAM1_TCB1D9_TCB1D9B	154..251	CDD:275420
		PH-GRAM2_TCB1D9_TCB1D9B	299..394	CDD:270161
		TBC	504..714	CDD:214540	71/218 (33%)
		EFh	<854..905	CDD:298682
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R540
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940