DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MARK1 and AMPKalpha

DIOPT Version :9

Sequence 1:	NP_001273053.1	Gene:	MARK1 / 4139	HGNCID:	6896	Length:	796	Species:	Homo sapiens
Sequence 2:	NP_477313.1	Gene:	AMPKalpha / 43904	FlyBaseID:	FBgn0023169	Length:	582	Species:	Drosophila melanogaster

Alignment Length:	689	Identity:	202/689 - (29%)
Similarity:	307/689 - (44%)	Gaps:	189/689 - (27%)

- Green bases have known domain annotations that are detailed below.

Human    40 IPRCRNSITSA-----TDEQP--HIGNYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLN 97
            :|:.|.:...|     .:.||  .||:|.|..|:|.|.|.|||:..|.:|..:|||||:::.::.
  Fly     1 MPQMRAAAAEAVAAGSANGQPLVKIGHYLLGATLGTGTFGKVKIGEHQITRVKVAVKILNRQKIK 65

Human    98 PTS-LQKLFREVRIMKILNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARA 161
            ... :.|:.||::.:|:..||:|:||::||.|...::::|||.||||:|||:|.||:::|.:||.
  Fly    66 SLDVVGKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMIMEYVSGGELFDYIVKHGKLQEHQARR 130

Human   162 KFRQIVSAVQYCHQKYIVHRDLKAENLLLDGDMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPE 226
            .|:||:|.|.|||:..|||||||.||||||.:|::||||||.||....|..|.|.||||.|||||
  Fly   131 FFQQIISGVDYCHRHMIVHRDLKPENLLLDHNMHVKIADFGLSNMMLDGEFLRTSCGSPNYAAPE 195

Human   227 LFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKL 291
            :..||.|.|||||:||.|||||.|:.|:||||.:::..|..::..|.:.||.|::....||:.::
  Fly   196 VISGKLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFRKIKSGIFPIPEYLNKQVVNLVCQM 260

Human   292 LVLNPIKRGSLEQIMKDRWMNVGHEEEELKPYTEPDPDFNDTKRID------IMVTMGFARDEIN 350
            |.::|:||.::|:|.|..|.     :::|..|..|.....|:..||      :....|....|::
  Fly   261 LQVDPLKRANIEEIKKHEWF-----QKDLPAYLFPSSIEQDSNVIDTYAVAEVCTKFGVKETEVH 320

Human   351 DALIN-QKYDEVMATYILLGRKPPEFEGGESLSSGNLCQRSRPSSDLNNSTLQSPAHLKVQRSIS 414
            ::|:: ..:|::...|                                        ||.:.
  Fly   321 NSLLSGDPHDQLAIAY----------------------------------------HLIID---- 341

Human   415 ANQKQRRFSDHAG----------------PSIPPAVSYTKRPQANSVESEQKEEWDKDVARKLGS 463
                .:||:|.|.                |..||.|     ||::           .|....|.:
  Fly   342 ----NKRFADDAANQINEINNFFVAGSPPPPPPPPV-----PQSS-----------MDHQAPLAT 386

Human   464 TTVG---SKSEMTASPLVGPER--KKSSTIPSNNVYSGGSMARRNTYVCERTTDRYVALQNGKDS 523
            .|||   |.|..||:| |.|..  ..|||||          .|.:........||.:|:
  Fly   387 VTVGGGTSASSGTATP-VPPVAGGTPSSTIP----------IRPHPERIAPMRDRQLAM------ 434

Human   524 SLTEMSVSSISSAGSSVASAVPSARPRHQKSMSTSGHPIKVTLPTIKDGSEAYRPGSTTQRVPAA 588
                    |:.::|   ..|.|....|       .|.|||
  Fly   435 --------SVQTSG---GGAFPEKTAR-------GGTPIK------------------------- 456

Human   589 SPSAHSISTATPDRTRFPRGSSSRSTFHG---EQLRERRSVAYNGPPASPSHETGAFAHARRGTS 650
                         |.::..|..|:|..:.   |..|..::::|.....:|.|    ....|:...
  Fly   457 -------------RAKWHLGIRSQSKPNDIMLEVYRAMKALSYEWKIINPYH----VRVRRQNVK 504

Human   651 TGIISKITSKFVRRDPSEGEASGRTDTSRSTSGEPKERD 689
            ||..||::.:..:.|..    |...|....|:.|.::.|
  Fly   505 TGKFSKMSLQLYQVDAK----SYLLDFKSLTNDEVEQGD 539

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MARK1	NP_001273053.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..40		202/689 (29%)
		STKc_MARK	59..311	CDD:270974	121/252 (48%)
		S_TKc	60..311	CDD:214567	121/251 (48%)
		UBA_MARK1	331..371	CDD:270588	8/46 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	377..495		29/138 (21%)
		MARK1-3_C	697..794	CDD:213381
AMPKalpha	NP_477313.1	STKc_AMPK_alpha	25..280	CDD:270981	123/254 (48%)
		UBA_AID_AMPKalpha	297..360	CDD:270521	13/110 (12%)
		AMPKA_C	457..580	CDD:213378	20/91 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910