DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MARK1 and KP78a

DIOPT Version :9

Sequence 1:	NP_001273053.1	Gene:	MARK1 / 4139	HGNCID:	6896	Length:	796	Species:	Homo sapiens
Sequence 2:	NP_650066.1	Gene:	KP78a / 41362	FlyBaseID:	FBgn0026064	Length:	705	Species:	Drosophila melanogaster

Alignment Length:	731	Identity:	287/731 - (39%)
Similarity:	396/731 - (54%)	Gaps:	129/731 - (17%)

- Green bases have known domain annotations that are detailed below.

Human     2 SARTPLPTVN-ERDTENHTS----VDGYTEPHIQPTKSSSRQNIP--------------RCRNSI 47
            |.:|.:...| |.|.::|.:    ..|.|.....||.|::.. :|              .|.:..
  Fly    18 SEKTAMTAANKENDPDSHFTGTIVTTGATAQPATPTTSNATA-LPATPTVAAGQDLGDGACSSKN 81

Human    48 TSATDEQPHIGN----YRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREV 108
            |.:..:....||    |::.||:|||||||||||.||.||||||:|:|||||||.::.|||:|||
  Fly    82 TDSKFQSYVNGNGNGVYKIIKTLGKGNFAKVKLAIHVPTGREVAIKVIDKTQLNTSARQKLYREV 146

Human   109 RIMKILNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYC 173
            :|||:|||||||:||:|||:|:||||||||||.||:||:||.:|||:|::||..|||:|||:|||
  Fly   147 KIMKLLNHPNIVRLFQVIESERTLYLVMEYASRGELFDHLVKNGRMRERDARVIFRQLVSAIQYC 211

Human   174 HQKYIVHRDLKAENLLLDGDMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQGKKYDGPEV 238
            |.|::|||||||||||||..||||||||||.|.|....:|:||||||||||||||.|:||.||||
  Fly   212 HSKFVVHRDLKAENLLLDQHMNIKIADFGFGNTFDPNAQLETFCGSPPYAAPELFMGRKYAGPEV 276

Human   239 DVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKLLVLNPIKRGSLE 303
            |.|||||:|||||||||||||..||||||||||||||:|:|:|.|||||::|.|||||.||.||.
  Fly   277 DAWSLGVVLYTLVSGSLPFDGGTLKELRERVLRGKYRVPYYISMDCENLMRKFLVLNPAKRTSLS 341

Human   304 QIMKDRWMNVGHEE-EELKPYTEPDPDFNDTKRIDIMVTMGFARDEINDALINQKYDEVMATYIL 367
            .:|.|:|:|:||:| :.|:|:.|...:..|..|.|::::||..|.::..::..|.:|::..||:|
  Fly   342 AVMSDKWINLGHDESDRLRPFREKPMELQDAARFDLLMSMGHKRRDVEQSVKGQLFDDIYCTYML 406

Human   368 LGRKPPEFEGGESLSSGNLCQRSR--PSSDLNNSTLQSPAHLKVQRSISANQKQRRFSDHAGPSI 430
            ||...|.        |.|...:..  |:.||....:.||.                      |:|
  Fly   407 LGVAKPR--------SSNRSTKPEAIPTVDLTTPAVSSPL----------------------PNI 441

Human   431 -PPAVSYT-------KRPQANSVESEQKEEWDKDVARKLGSTTVGSKSEMTASPLVGPERKKSST 487
             .|.|:..       |.|..:|..:.         .|.:......:.:..|::|..||..|.:..
  Fly   442 TTPTVTIAHVTLALDKNPPIHSSSAS---------GRPIAPRLANAPNTPTSTPPTGPPAKPTRR 497

Human   488 IPSNNVYSGGSMARRNTYVCERTTDRYVALQNGKDSSLTEMSVSSISSAGSSVASAVPSARPRHQ 552
            .|:.      :.||       :.|:........:.|||.....|..:||...|...:.||:.:..
  Fly   498 TPAR------TPAR-------KATNHTSGQGRPEPSSLPHTPQSKRASANMDVKPTLLSAQRQLA 549

Human   553 KSMSTSGHPIKVTLPTIKDGSEAY----RPGSTTQRV-PAASPSAHSISTA-------------- 598
            ::...:..|.:...|..:..::|.    ||.:..::. ||.:|.....|.|
  Fly   550 QTQKLANTPPRFQYPVAQTPNQAQGSSRRPTTLYEKAEPAVTPLLVPKSPAMGARLLERIPGGGA 614

Human   599 ---TPDRTRFPRGSSSRSTFHGEQLRERR------------SVAYNGPPASPSHETGAFAHARRG 648
               |.|:. |.|.:.:|:|||..|.|..:            ..:|..||.|..       ..:..
  Fly   615 VEKTSDKP-FTRQNVARATFHFGQARSGKRGGGSGNGAGGEEDSYQTPPLSAD-------DTKPA 671

Human   649 TSTGIISKITSKFVRR 664
            :..|..||:|::|.||
  Fly   672 SRVGFFSKLTARFGRR 687

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MARK1	NP_001273053.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..40		11/42 (26%)
		STKc_MARK	59..311	CDD:270974	186/255 (73%)
		S_TKc	60..311	CDD:214567	185/250 (74%)
		UBA_MARK1	331..371	CDD:270588	13/39 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	377..495		21/127 (17%)
		MARK1-3_C	697..794	CDD:213381
KP78a	NP_650066.1	PKc_like	98..349	CDD:304357	185/250 (74%)
KP78a	NP_650066.1	S_TKc	98..349	CDD:214567	185/250 (74%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0586
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24346
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910