Protein Alignment MARK1 and sff

DIOPT Version :10

• Sequence 1: NP_001273053.1
• Gene: MARK1 / 4139
• HGNCID: 6896
• Length: 796
• Species: Homo sapiens
• Sequence 2: NP_648814.3
• Gene: sff / 39732
• FlyBaseID: FBgn0036544
• Length: 861
• Species: Drosophila melanogaster
• Alignment Length: 847
• Identity: 243/847 - (28%)
• Similarity: 375/847 - (44%)
• Gaps: 199/847 - (23%)

Human    45 NSITSATDEQPHIGNYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVR 109
            |::|:  :....:|.|||:||:|||....|||..|.:.|::||:|||::.:|:.:.|.|:.||:.
  Fly     5 NNVTA--ENCQFVGPYRLEKTLGKGQTGLVKLGVHCVIGKKVAIKIINREKLSESVLMKVEREIA 67

Human   110 IMKILNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCH 174
            |||:::||:::.|.:|.|.:|.|||::|:.||||:|||||..||:..||||..||||:||:.:||
  Fly    68 IMKLIDHPHVLGLSDVYENKKYLYLILEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCH 132

Human   175 QKYIVHRDLKAENLLLDGDMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQGKKYDGPEVD 239
            ...|.|||||.||||||...||||||||.::....|:.|:|.||||.||.||:.:|:||||.:.|
  Fly   133 SHSICHRDLKPENLLLDEKNNIKIADFGMASLQPAGSMLETSCGSPHYACPEVIRGEKYDGRKAD 197

Human   240 VWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKLLVLNPIKRGSLEQ 304
            |||.|||||.|:.|:||||..||::|.|:|.||.:.||.::..||::||:.::.:||.:|.:|.:
  Fly   198 VWSCGVILYALLVGALPFDDDNLRQLLEKVKRGVFHIPHFVPPDCQSLLRGMIEVNPDRRLTLAE 262

Human   305 IMKDRWMNVGHEEE-ELK-------------PYTEPDPDFNDTKRIDIMVTMGFARDE---INDA 352
            |.:..|:..|.:.| ||:             ..|..|||.     ::.:.::|..:::   |.:.
  Fly   263 INRHPWVTAGGKGELELELPMMEVVQTHVIPTATAVDPDV-----LNAICSLGCFKEKEKLIQEL 322

Human   353 LINQKYDEVMATYILLGRK--PPEFEGGESLSSGNLCQRSRPSSD-------------LNNSTLQ 402
            |.:....|.:..::||.||  .|..|..:.::     |:||...|             :|.:  .
  Fly   323 LSSSHNTEKVIYFLLLERKRRRPALEDDDEIA-----QKSRSELDAVDPPRKRLDTCRINGT--N 380

Human   403 SPAHLKVQ--------------RSISANQKQRRFSDHAGPSIPPAVSYTKRPQANSVESEQKEEW 453
            :|::.::.              ||.|:.:..:|.|.....|...:.||....:.||..|..:::
  Fly   381 APSYGQISEGSPLTPRRQAFNFRSYSSTRNHQRRSPTTVTSSVRSSSYHSPTRCNSPMSSAQQQ- 444

Human   454 DKDVARKLGSTTVGSKSEMTASPLVGPERKKSSTIPSNNVYSGGSMARRNTYVCERTTDRYVALQ 518
                         .:.....:||..|                    .|.:||     .||.   :
  Fly   445 -------------ANAISRPSSPAAG--------------------TRHSTY-----GDRD---R 468

Human   519 NGKDSSLTEMSVSSISSAGSSVASAVPSARPRHQKSMSTSGHPIKVTLPTIK----------DGS 573
            :|..||:                    |..|.|....|..|..:.|..|.|:          .||
  Fly   469 SGHHSSV--------------------SRTPSHSSQKSIEGDVVVVREPRIERRDSLRQERGGGS 513

Human   574 EAYR---------PGSTTQRVPAASPSAHSISTATPDRTRFPRGSSSRSTFH-----------GE 618
            ...|         ||..:....:||||.|..:.:.|        :.:.|.||           |.
  Fly   514 PRDRGDCGIPPGSPGGNSSGSTSASPSVHHRANSGP--------TIAISMFHDPDSNSVVNPNGS 570

Human   619 QLRERRSVAYNGPPASPSHETGAFAHARRGTSTGIISKITSKFVRR--DPSEGEA-----SGRTD 676
            .:....|   .|.|.||.:..|......|.|:.......:.:|.||  ..|..|.     |....
  Fly   571 PMMNNSS---PGMPGSPCNTPGGQLWKTRLTNIKNSFLGSPRFHRRKMQVSADEVHLTPESSPEL 632

Human   677 TSRSTSGEPKERDKEE-------GK---DSKPRSLRFTWSMK--TTSSMDPNDMMREIRKVLDAN 729
            |.||..|.....:|:|       ||   ..|...:....||.  :.|.:.|.....|.::    |
  Fly   633 TKRSWFGNLITTEKDETFTILVKGKPIATVKAHLIHAFLSMAELSHSVVSPTSFRVEYKR----N 693

Human   730 NCDYEQKERFLLFCVHGDARQDSLVQWEMEVCKLPRLS--LNGVRFKRISGTSIAFKNIASKIAN 792
            .......:|.:.|.|...|           :||...::  |..:.|..:||....|:.|...|.:
  Fly   694 GNGPVMFQRHVKFQVDISA-----------ICKQGDIADMLFALTFTLLSGNIRRFRRICEHIQS 747

Human   793 EL 794
            ::
  Fly   748 QV 749

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MARK1	NP_001273053.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..40
		STKc_MARK	59..311	CDD:270974	128/251 (51%)
		UBA_MARK1	331..371	CDD:270588	6/42 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	377..495		20/144 (14%)
		MARK1-3_C	697..794	CDD:213381	20/100 (20%)
sff	NP_648814.3	STKc_BRSK1_2	16..269	CDD:270983	129/252 (51%)
		UBA_BRSK	298..350	CDD:270525	13/56 (23%)