DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment MARK1 and Sik2

DIOPT Version :9

Sequence 1:NP_001273053.1 Gene:MARK1 / 4139 HGNCID:6896 Length:796 Species:Homo sapiens
Sequence 2:NP_569972.1 Gene:Sik2 / 31170 FlyBaseID:FBgn0025625 Length:1398 Species:Drosophila melanogaster


Alignment Length:805 Identity:270/805 - (33%)
Similarity:393/805 - (48%) Gaps:180/805 - (22%)


- Green bases have known domain annotations that are detailed below.


Human    23 GYTEPHIQPTKSS------SRQNIPRCRNSITSATDEQPHIGNYRLQKTIGKGNFAKVKLARHVL 81
            |.:.|...||.|:      |.:::.:.:        |...:|.|.:::||||||||.||||||.:
  Fly   106 GGSTPGPSPTSSAVGAGGISGKDLLKLK--------EPMRVGFYDIERTIGKGNFAVVKLARHRI 162

Human    82 TGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFEVIETEKTLYLVMEYASGGEVFD 146
            |..|||:|||||:||:.|:|||::|||.|||.|.||:|:||::|:||:..:|:|.||||.||:||
  Fly   163 TKNEVAIKIIDKSQLDQTNLQKVYREVEIMKRLKHPHIIKLYQVMETKNMIYIVSEYASQGEIFD 227

Human   147 YLVAHGRMKEKEARAKFRQIVSAVQYCHQKYIVHRDLKAENLLLDGDMNIKIADFGFSNEFTVGN 211
            |:..:|||.|..||.||.||:|||:|||:|.||||||||||||||.:||||||||||||.|..|.
  Fly   228 YIAKYGRMSESAARFKFWQIISAVEYCHKKGIVHRDLKAENLLLDLNMNIKIADFGFSNHFKPGE 292

Human   212 KLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRI 276
            .|.|:||||||||||:|:||:|.|||:|:|||||:||.||.|:|||||..|:.||:|||.|::||
  Fly   293 LLATWCGSPPYAAPEVFEGKQYTGPEIDIWSLGVVLYVLVCGALPFDGSTLQSLRDRVLSGRFRI 357

Human   277 PFYMSTDCENLLKKLLVLNPIKRGSLEQIMKDRWM-------------NVGHEEEELKPYTEPDP 328
            ||:||::||:|::::|||.|.:|.:::||.:.|||             |:|.|.:   ...||..
  Fly   358 PFFMSSECEHLIRRMLVLEPTRRYTIDQIKRHRWMCPELLEHVLIAKYNLGAERQ---TSVEPSE 419

Human   329 DFNDTKRIDIMVT-MGFARDEINDALINQKYDEVMATYILL----GRKPPEFEG------GESLS 382
            |.     :.||.. :|...|:...:|....||.|.|.|:||    ..|..:..|      ..|.|
  Fly   420 DI-----LRIMAEYVGIGSDKTRASLKKNTYDHVAAIYLLLQDRVSHKKEQSNGLGASALASSTS 479

Human   383 SGNLCQRSR------------PSSDLNNSTL--QSPAHLKVQRSISANQKQRRFSDHAG--PSIP 431
            :..:...||            .|..::.|::  :...|.::.|..:....:|  :.|||  |::|
  Fly   480 ASRMIYSSRNDHQPTQQQSQQQSKTISTSSILAKDQCHKRLSRHQTVLMSER--NAHAGATPTVP 542

Human   432 -PAVSYTKR------PQANSVESEQKEEWDKDVARKLGSTTVGSKSEMTASPLVGPER-----KK 484
             |...|..:      |...:..|.            |.....|...|:.||.:..|.|     ..
  Fly   543 DPGPGYYAKYGPLQLPLPLTGHSH------------LTGYLNGGGVEVDASGIPLPMRYTPLPTA 595

Human   485 SSTIPSNNVYSGGSMARRNTYVCERTTDRYVALQNGKDSSLTEMSVSSISSAGSSVASAVPS-AR 548
            :|..|||...:...:.|.:.......:.|.||:....|::                    || |.
  Fly   596 ASPAPSNCSSTSSRVGRHSLSSSSPRSHRPVAISLSIDNN--------------------PSLAN 640

Human   549 PRHQKSMSTSGHPIKVTLPTIKDGSEAYRPGSTTQRVPAASPSAHS------ISTATPDRTRFPR 607
            .|.::.|...|.|:...                  .||.||...|.      |..:|.|.....:
  Fly   641 LRCREMMEAGGGPVGAV------------------GVPLASKQLHQTISEFIIKQSTEDCRALLQ 687

Human   608 GSSSRSTFHGEQLRERRSVAYNGPPASPSHETGAFAHARRGTSTGIISKITSKFVRRDPSEGEAS 672
            .|::.:....:..:...||....||||.: .|.:.|....|::               |..||.:
  Fly   688 QSTAVAEGKDDPPKAESSVGGVPPPASTT-PTSSTAGPESGSA---------------PCPGEIN 736

Human   673 GRTDTSRSTSGEPKERDKEEGKDSKPRSLRFTWSMKTTSSMDPNDMMREIRKVLDANNCDYEQ-- 735
            |:|..:.|:|      ...:.|.:..:|.|:..|.:.:          ::.:.|..:....||  
  Fly   737 GKTIKTMSSS------SSFDSKANLGQSFRYKMSAEAS----------KLFQTLQESPLPVEQRT 785

Human   736 KERFLLFCVH--------GDARQDS 752
            |.|     ||        ||:.|::
  Fly   786 KRR-----VHVGSTNGSGGDSGQET 805

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MARK1NP_001273053.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..40 6/22 (27%)
STKc_MARK 59..311 CDD:270974 160/251 (64%)
S_TKc 60..311 CDD:214567 160/250 (64%)
UBA_MARK1 331..371 CDD:270588 12/44 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 377..495 30/151 (20%)
MARK1-3_C 697..794 CDD:213381 13/66 (20%)
Sik2NP_569972.1 STKc_SIK 140..392 CDD:270973 160/251 (64%)
S_TKc 141..392 CDD:214567 160/250 (64%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0586
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000311
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.810

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