Protein Alignment CG5342 and PIGO

DIOPT Version :10

• Sequence 1: NP_650088.2
• Gene: CG5342 / 41389
• FlyBaseID: FBgn0037916
• Length: 837
• Species: Drosophila melanogaster
• Sequence 2: NP_116023.2
• Gene: PIGO / 84720
• HGNCID: 23215
• Length: 1089
• Species: Homo sapiens
• Alignment Length: 819
• Identity: 155/819 - (18%)
• Similarity: 254/819 - (31%)
• Gaps: 318/819 - (38%)

  Fly    18 AVVLIYLRSTYPGSLEPQEVEHLKEPPPADRLVVLVRDGLSAQSFLANRCTNVP------LLREL 76
            |.:.:|..:....|..|:|.|.:.:......|.:|:  ||.           :|      ::.||
Human   296 AALFLYSPTAVFPSTPPEEPEVIPQVSLVPTLALLL--GLP-----------IPFGNIGEVMAEL 347

  Fly    77 FL-------HQGLVGISRPETITYHSISPYISLFSGFNEDAASVARGWLGTPASIDSIFDRCKRS 134
            |.       |...:..:....:....:|.::..:|...:|..:...      ..:.::|.:....
Human   348 FSGGEDSQPHSSALAQASALHLNAQQVSRFLHTYSAATQDLQAKEL------HQLQNLFSKASAD 406

  Fly   135 FAWTTTELISRFPKIERPR--ELSFETYGEGVTKSCSEMEDF------VC-RSVQRF----LGGG 186
            :.|.          ::.|:  |.:..|.       .:|::.|      :| .|..||    :.||
Human   407 YQWL----------LQSPKGAEATLPTV-------IAELQQFLRGARAMCIESWARFSLVRMAGG 454

  Fly   187 SRLLLNTTGVIFFIHMTGVEPS---CESLQRIQENVWNVYKSFEKTFPDQRTAYLFTSNLGDPQT 248
            :.||..:..:........:.|.   |..|  :....|.:.           .|..:...||..:.
Human   455 TALLAASCFICLLASQWAISPGFPFCPLL--LTPVAWGLV-----------GAIAYAGLLGTIEL 506

  Fly   249 KSEY----SLAVESPF--FLWGSGVNHIKSMPGRSFMANEAGLRLPLHVLNTPHLTALMSALLGV 307
            |.:.    ::|..|.|  |||       |:..|       .|.:.||            :.|..:
Human   507 KLDLVLLGAVAAVSSFLPFLW-------KAWAG-------WGSKRPL------------ATLFPI 545

  Fly   308 PPPVYSRGMLPKGMLNASLRYEANAMLINAKQLLAQARRLRELHPKRMPAFWLSFQMMDNFVKES 372
            |.||         :|....|.   |:..:...::|:||....|              :.:|:
Human   546 PGPV---------LLLLLFRL---AVFFSDSFVVAEARATPFL--------------LGSFI--- 581

  Fly   373 LALKKQRRFRA-LLDYSCNYMPVLIKGMDYFKDYYRHVSITAVSFAGIAWIYCLR---------- 426
            |.|..|..:.. ||......||.|  |.....:..||....|:.. ||..:.|.|
Human   582 LLLVVQLHWEGQLLPPKLLTMPRL--GTSATTNPPRHNGAYALRL-GIGLLLCTRLAGLFHRCPE 643

  Fly   427 ----CHLT---------VGKKCRNLIEIQEVISSKRLVYARGFHRLLTGVLVIIMMLERIPLVVQ 478
                ||.:         ||.:.:||                 ::......||
Human   644 ETPVCHSSPWLSPLASMVGGRAKNL-----------------WYGACVAALV------------- 678

  Fly   479 AILLIPSLYWRTTLKILGERPKMVCRKSLMSTALLALICFGGFFRRYILAVGYLGFASYNNREAF 543
            |:|....|:.|....:....|.|:                   |.|:.|.:..||.|:|
Human   679 ALLAAVRLWLRRYGNLKSPEPPML-------------------FVRWGLPLMALGTAAY------ 718

  Fly   544 KRRGHQFYLWLL-------------LLLGLTVVSALPESL-GCSQPG-ALMFSIFLTVLRPLACG 593
                     |.|             |:.|.::|  ||.:: |.:..| ||:....:|||.....|
Human   719 ---------WALASGADEAPPRLRVLVSGASMV--LPRAVAGLAASGLALLLWKPVTVLVKAGAG 772

  Fly   594 V--YLNLLTWLSNIPVLLAALEYILIGWHPWIMYLVSWIYLGFLVLWQRRNLQASEVFFFDLSTL 656
            .  ...:||..|..|...|.|:|:           |..||         |::|  |.|
Human   773 APRTRTVLTPFSGPPTSQADLDYV-----------VPQIY---------RHMQ--EEF------- 808

  Fly   657 YTLTCTSYESVVIQMLAMELQLALRMKLKRNESIGPKTAAHYIL--VYS--WYSLFIIGSFPAFD 717
                                    |.:|:|.:|.||.|.|.|.|  |||  ..:...:.:||
Human   809 ------------------------RGRLERTKSQGPLTVAAYQLGSVYSAAMVTALTLLAFP--- 846

  Fly   718 DFLDILHETCFGYSPLTYGLVMVLKLILPWLLVLCIMAG 756
              |.:||..       ...||.:|..:..:||:..:.||
Human   847 --LLLLHAE-------RISLVFLLLFLQSFLLLHLLAAG 876

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5342	NP_650088.2	GPI_EPT_1	43..318	CDD:293744	50/309 (16%)
		PigN	397..781	CDD:461508	83/404 (21%)
PIGO	NP_116023.2	GPI_EPT_3	65..344	CDD:293747	11/60 (18%)