DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6790 and MCD4

DIOPT Version :9

Sequence 1:	NP_650087.2	Gene:	CG6790 / 41388	FlyBaseID:	FBgn0037915	Length:	897	Species:	Drosophila melanogaster
Sequence 2:	NP_012756.1	Gene:	MCD4 / 853690	SGDID:	S000001648	Length:	919	Species:	Saccharomyces cerevisiae

Alignment Length:	981	Identity:	212/981 - (21%)
Similarity:	382/981 - (38%)	Gaps:	243/981 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 VLVHLLLLICIMRIFYQSGPLSQLEPQKTLLDMGVP-PAADRLVVFLLEGLRADTLF---SDNCS 108
            ||.||..|..|..|::.|..:..:.|.::     .| |.|.||.:.:.:||||||.|   :...|
Yeast    14 VLFHLFYLWSIFDIYFISPLVHGMSPYQS-----TPTPPAKRLFLIVGDGLRADTTFDKVTHPVS 73

  Fly   109 G-----AVYIRDIILRQGLVGISKTSVPTLTRSAEVALFAGF-------------NPMPSILPTS 155
            |     |.:||.:::.....|||.|.:||.:|...||:.|||             ||:
Yeast    74 GKTEFLAPFIRSLVMNNATYGISHTRMPTESRPGHVAMIAGFYEDVSAVTKGWKSNPV------- 131

  Fly   156 NFDTIFNR---TLAF------------------------------------DKGAFLRFSHLSDL 181
            |||:.||:   |.:|                                    :..||: |.||..|
Yeast   132 NFDSFFNQSTHTYSFGSPDILPMFKDGASDPNKVDTWMYDHTFEDFTQSSIELDAFV-FRHLDQL 195

  Fly   182 RRRLTKRACLEKLWYANKLVMLVNLAEVGGASPLDIGFQMKLHNTQRNIRDAYEL----IEATFN 242
            ....|..:.|:.....:..|..::|.....|......:..:.::..:.|.|...:    :...|.
Yeast   196 FHNSTLNSTLDYEIRQDGNVFFLHLLGCDTAGHSYRPYSAEYYDNVKYIDDQIPILIDKVNKFFA 260

  Fly   243 DSKTAYLYTSAHGLTYFGSHGGGSDEEREAPFLLWGAGVKH-------VTENITSDFVLNNGVGM 300
            |.|||:::|:.||::.|||||.|.......|.:.||||:..       |::|.|.::.|::   :
Yeast   261 DDKTAFIFTADHGMSAFGSHGDGHPNNTRTPLVAWGAGLNKPVHNPFPVSDNYTENWELSS---I 322

  Fly   301 QLHKLDQIQLAPLMSALIGLPPPVNNLAILPQGYMKVSREYARKSVHLNALQLLTQ--------- 356
            :.:.:.|..:|.|||.|||:..|.|::..||..|:.........:::.||..:|.|
Yeast   323 KRNDVKQADIASLMSYLIGVNYPKNSVGELPIAYIDGKESDKLAALYNNARSILEQYLVKQDEVI 387

  Fly   357 -----AKAIIRLHERGVFHKWLPKDKDLDLQQIAYYQNQMDHLLDMGWRSKALETSTLAIKVALK 416
                 .|...:..|:...| :|.:.:.| :|:|:..:|.::        .:|:..:...:::.|:
Yeast   388 DSQFFYKEYFKFVEKSHSH-YLEEIETL-IQRISEGENYLE--------QEAITLTEELMQITLE 442

  Fly   417 SLKFY--HNYYHIPLVVTTVLALLGWQFYQLV-----KLSQNVM-----AP--HYMRRGYLTWCT 467
            .|.:.  :|:..|..:||  ...:||.|:..:     .:.:||:     :|  |          .
Yeast   443 GLHYLTTYNWRFIRTIVT--FGFVGWIFFSFIIFLKSFILENVIDDQKASPLSH----------A 495

  Fly   468 IFLASLGLLLGEMVFLQWAPFMTVICLVVPFGVWCMTLAALPQNGGWIFEPLKHLR--------- 523
            :| .|:|:||..::|.|.:||...:.|:.|...|           .:||.....||
Yeast   496 VF-GSIGILLNWILFYQHSPFNFYMYLLFPLYFW-----------SYIFTNRSVLRSGIKEFFKG 548

  Fly   524 ---WIVGPAAVMIASIYCNCPLSLAYILCVGFYNRRGW----------LHP--------SPKFLA 567
               |......:.|.|:|    ..:.|    ||::|  |          .:|        |...|
Yeast   549 TSPWKRVLITISIISVY----EGIVY----GFFHR--WTFTLITNILAFYPFICGVRELSVNIL- 602

  Fly   568 WLALVLLLGGFLWSQ------------KGMQILMTTNYRV---------VLQAISMLVVIVRPCV 611
            |:...:||..|....            .|:.|:::..|.:         ..:||..:.:.:...:
Yeast   603 WIITSVLLSTFTLFDAVKIEDLNQIHLAGLLIILSAFYALYKIHSRINSYTRAIFAIQISLVAAM 667

  Fly   612 LNENHKWKVWVINGGILFVAAIGIFLKEMGKPVPLYLFAANWAYLIYAFASVPCSSRTTPQS--- 673
            |...|:             :.|.:.|::   .:|.....|.|.....:...:|......|.:
Yeast   668 LAVTHR-------------SVISLQLRQ---GLPRESQVAGWIIFFVSLFVMPILHYRKPNNDYK 716

  Fly   674 -RLELIRFNLLTLHVLLSDSYVSLFAQGLIIEYQM-GLEVHEKFKEADEDVKILTSSKHLQMCYR 736
             ||.:|........::|:.|:.||| ..|...|.: .:|:..|.||    :|.......||:
Yeast   717 VRLLIIYLTFAPSFIILTISFESLF-YFLFTSYMVQWIEIENKIKE----MKTQKDENWLQV--- 773

  Fly   737 FAVSILLYF--YASLFGTGHWVGGFTYLANSARLFLPDSSSGLVPLLVLIHLLIPSIVIMASVVA 799
            ..||::.:|  ..:.||||:.....::...|....||.....|:..|:::.|:||..::...:..
Yeast   774 LRVSVIGFFLLQVAFFGTGNVASISSFSLESVCRLLPIFDPFLMGALLMLKLIIPYGLLSTCLGI 838

  Fly   800 LSSFGRQQIRTIFSSLMLICNAVVLFFVVFVPHNAYWPMAHPSVVHALLAQLTVILILACESIVT 864
            |:.....:..||.|.::.:.:.:.|.|...:.....|.....::.:..||.|:.:.:|..|.:..
Yeast   839 LNLKLNFKDYTISSLIISMSDILSLNFFYLLRTEGSWLDIGITISNYCLAILSSLFMLILEVLGH 903

  Fly   865 IFFRRL 870
            :..:.:
Yeast   904 VLLKNV 909

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6790	NP_650087.2	GPI_EPT_1	83..331	CDD:293744	84/319 (26%)
CG6790	NP_650087.2	PigN	418..821	CDD:282796	94/474 (20%)
MCD4	NP_012756.1	GPI_EPT_1	46..353	CDD:293744	83/317 (26%)
MCD4	NP_012756.1	PigN	443..874	CDD:398585	96/489 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346531
Domainoid	1	1.000	73	1.000	Domainoid score	I2183
eggNOG	1	0.900	-	-		E1_COG1524
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1579
OMA	1	1.010	-	-		QHG55072
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12250
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	8	7.760