DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6790 and PIGO

DIOPT Version :9

Sequence 1:	NP_650087.2	Gene:	CG6790 / 41388	FlyBaseID:	FBgn0037915	Length:	897	Species:	Drosophila melanogaster
Sequence 2:	NP_116023.2	Gene:	PIGO / 84720	HGNCID:	23215	Length:	1089	Species:	Homo sapiens

Alignment Length:	1052	Identity:	201/1052 - (19%)
Similarity:	323/1052 - (30%)	Gaps:	361/1052 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 SQLEPQKTLLDMGVPPAADRLVVFLLEGLRADTLFSDNCSGAVYIRDIILRQGLVGISKTSVPTL 133
            ||::|..|.:..........|..|:..|        .|.:....:.|.:::|            |
Human   123 SQVDPPTTTMQRLKALTTGSLPTFIDAG--------SNFASHAIVEDNLIKQ------------L 167

  Fly   134 TRSAEVALFAGFNPMPSILPTSNFDTIFNRTLAFDKGAFLRFSHLSDLRRRLTKRACLEKL---- 194
            |.:....:|.|.:....:.|.           ||.|..|....::.||  .......||.|
Human   168 TSAGRRVVFMGDDTWKDLFPG-----------AFSKAFFFPSFNVRDL--DTVDNGILEHLYPTM 219

  Fly   195 ----WYANKLVMLVNLAEVGGA----SPLDIGFQMKLHNTQRNIRDAYELIEATFNDSKTAYLYT 251
                |.    |::.:...|...    .|.......||....:.|:...|.:|   ||  |..:..
Human   220 DSGEWD----VLIAHFLGVDHCGHKHGPHHPEMAKKLSQMDQVIQGLVERLE---ND--TLLVVA 275

  Fly   252 SAHGLTYFGSHGGGSDEEREAPFLLWGAGVKHVTENITSDFVLNNGVGMQLHKLDQIQLAPLMSA 316
            ..||:|..|.|||.|:.|..|...|:           :...|..:....:...:.|:.|.|.::.
Human   276 GDHGMTTNGDHGGDSELEVSAALFLY-----------SPTAVFPSTPPEEPEVIPQVSLVPTLAL 329

  Fly   317 LIGLPPPVNN----LAILPQG---YMKVSREYARKS-VHLNALQLLTQAKAIIRLHERGVFHKWL 373
            |:|||.|..|    :|.|..|   ....|...|:.| :||||.|:            ....|.:.
Human   330 LLGLPIPFGNIGEVMAELFSGGEDSQPHSSALAQASALHLNAQQV------------SRFLHTYS 382

  Fly   374 PKDKDLDLQQIAYYQNQMDHL-LDMGWRSKALETSTLAIKVALKSLKFYHNYYHIPLVVTTVLAL 437
            ...:||..:::...||..... .|..|..::.:.:...:...:..|:.:       |.....:.:
Human   383 AATQDLQAKELHQLQNLFSKASADYQWLLQSPKGAEATLPTVIAELQQF-------LRGARAMCI 440

  Fly   438 LGWQFYQLVKL-----------------SQNVMAPHYMRRGYLTWCTIFLASL--GL-------- 475
            ..|..:.||::                 ||..::|.:      .:|.:.|..:  ||
Human   441 ESWARFSLVRMAGGTALLAASCFICLLASQWAISPGF------PFCPLLLTPVAWGLVGAIAYAG 499

  Fly   476 LLG------EMVFL---------------QWA------PFMTVICLVVPFGVWCMTLAALP---- 509
            |||      ::|.|               .||      |..|:  ..:|..|..:.|..|.
Human   500 LLGTIELKLDLVLLGAVAAVSSFLPFLWKAWAGWGSKRPLATL--FPIPGPVLLLLLFRLAVFFS 562

  Fly   510 -------------QNGGWIFEPLKHLRW---IVGPAAVMI----ASIYCNCP---------LSLA 545
                         ..|.:|...:..|.|   ::.|..:.:    .|...|.|         |.:.
Human   563 DSFVVAEARATPFLLGSFILLLVVQLHWEGQLLPPKLLTMPRLGTSATTNPPRHNGAYALRLGIG 627

  Fly   546 YILC---VGFYNR----RGWLHPSPKFLAWLA-LVLLLGG---FLWSQKGMQILMTTNYRVVLQA 599
            .:||   .|.::|    ....|.||    ||: |..::||   .||            |...:.|
Human   628 LLLCTRLAGLFHRCPEETPVCHSSP----WLSPLASMVGGRAKNLW------------YGACVAA 676

  Fly   600 ISMLVVIVRPCVLNENHKWKVWVINGGILFVAAIGIFLKEMGKPVPLYLFAANWAYLIYAFASVP 664
            :..|:..||           :|:...|.|......:.....|.|:.....||.||....|..:.|
Human   677 LVALLAAVR-----------LWLRRYGNLKSPEPPMLFVRWGLPLMALGTAAYWALASGADEAPP 730

  Fly   665 CSSRTTPQSRLELIRFNLLTLHVLLSDSYVSLFAQGLIIEYQMGLEVHEK--------------- 714
                     ||.::   :....::|..:...|.|.||.:.....:.|..|
Human   731 ---------RLRVL---VSGASMVLPRAVAGLAASGLALLLWKPVTVLVKAGAGAPRTRTVLTPF 783

  Fly   715 ----FKEADEDVKILTSSKHLQMCYR---------FAVSILLYFYASLFGTGHWVGGFTYLANSA 766
                ..:||.|..:....:|:|..:|         ..:::..|...|::... .|...|.|| ..
Human   784 SGPPTSQADLDYVVPQIYRHMQEEFRGRLERTKSQGPLTVAAYQLGSVYSAA-MVTALTLLA-FP 846

  Fly   767 RLFLPDSSSGLVPLL------VLIHLLIPSIVIMA--------------SVVALSSF---GRQQI 808
            .|.|......||.||      :|:|||...|.:..              :::|..:|   |.|.:
Human   847 LLLLHAERISLVFLLLFLQSFLLLHLLAAGIPVTTPGPFTVPWQAVSAWALMATQTFYSTGHQPV 911

  Fly   809 -------------------RTIFSSLMLICN--AVVLFFVVFVPHNAYWPMA------------- 839
                               .|...:|::..|  |..|.|.|..|....||..
Human   912 FPAIHWHAAFVGFPEGHGSCTWLPALLVGANTFASHLLFAVGCPLLLLWPFLCESQGLRKRQQPP 976

  Fly   840 ------------------------HPSVVHALLAQLTV-------ILILACESIVTIFFRRLNMN 873
                                    .|...:|.|.||.:       |.||||....:|..|.|.:
Human   977 GNEADARVRPEEEEEPLMEMRLRDAPQHFYAALLQLGLKYLFILGIQILACALAASILRRHLMV- 1040

  Fly   874 RCSDWRQEADEF 885
                |:..|.:|
Human  1041 ----WKVFAPKF 1048

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6790	NP_650087.2	GPI_EPT_1	83..331	CDD:293744	54/263 (21%)
CG6790	NP_650087.2	PigN	418..821	CDD:282796	103/572 (18%)
PIGO	NP_116023.2	Npp1	42..>299	CDD:224441	46/217 (21%)
PIGO	NP_116023.2	GPI_EPT_3	65..344	CDD:293747	57/273 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1524
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810