DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6790 and pign

DIOPT Version :9

Sequence 1:	NP_650087.2	Gene:	CG6790 / 41388	FlyBaseID:	FBgn0037915	Length:	897	Species:	Drosophila melanogaster
Sequence 2:	NP_001297009.1	Gene:	pign / 556797	ZFINID:	ZDB-GENE-080204-114	Length:	932	Species:	Danio rerio

Alignment Length:	999	Identity:	235/999 - (23%)
Similarity:	416/999 - (41%)	Gaps:	247/999 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 RRLTYRLVGKVQVLMELWKSKVVLVHLLLLICIMRIFYQSGPLSQLEPQKTLLDMGVPPAADRLV 90
            :.:|:.:||             ::||::..:||..|::.|..:..:.||:    :.:||.|.|||
Zfish     2 KMVTFFVVG-------------LIVHVVFFLCIFDIYFTSPLVHGMTPQR----VSLPPPAKRLV 49

  Fly    91 VFLLEGLRADTLFSDNCSG---AVYIRDIILRQGLVGISKTSVPTLTRSAEVALFAGF------- 145
            :|:.:|||||:||..:.||   |.|:|.:|...|..|:|.|.|||.:|...|||.|||
Zfish    50 LFVADGLRADSLFKPDDSGTSRAPYLRSVIEEGGTWGVSHTRVPTESRPGHVALIAGFYEDVSAV 114

  Fly   146 ------NPMPSILPTSNFDTIFNRTL------------AFDKGA----------------FLR-- 174
                  ||:       .||::||.:.            .|.|||                |..
Zfish   115 AKGWKENPV-------EFDSVFNESRYTWCWGSPDILPMFAKGATGDHVYTHTYPPEREDFASTD 172

  Fly   175 --------FSHLSDLRRRLTKRACLEKLWYANKLVMLVNLAEVGGASPLDIGFQMKLHNTQRNIR 231
                    |..:.|..........|.|..:..:.|..::|          :|.....|..:...:
Zfish   173 ASRLDTWVFDEVKDFLTAAKSNETLLKKLHEEQNVFFLHL----------LGIDTNGHAHRPMSK 227

  Fly   232 DAYE---LIEATF------------NDSKTAYLYTSAHGLTYFGSHGGGSDEEREAPFLLWGAGV 281
            :..|   |::|..            :|.||||::||.||:|.:||||.|...|...|.::|||||
Zfish   228 ECLENIGLVDAGVADIVTVMDDFYGHDGKTAYVFTSDHGMTNWGSHGAGHPSETLTPLVVWGAGV 292

  Fly   282 KHV---TENITSDFVLNNGVGMQLHK---LDQIQLAPLMSALIGLPPPVNNLAILPQGYMKVSRE 340
            :..   |.....|..|... |::.::   ::|..:|||||:|||:|.|:|::.:||..|:..|:.
Zfish   293 QKAQWETSQKYEDNYLKEW-GLESYRRVDVNQADIAPLMSSLIGIPFPLNSVGVLPLSYLNNSQH 356

  Fly   341 YARKSVHLNALQLLTQAKA-IIRLHERGVFHKWLPKDKDLDLQQIAYYQNQMDHLLDMGWRSKAL 404
            :..:|::.||:|:|.|.:. :.:..|..:...:.|.....|.:|:.:.:...| |:..|...:|:
Zfish   357 FKAESMYANAIQILEQFRVKLAQKKETTISFLFTPYQPLTDSKQVDFIRQARD-LIQKGRFDEAI 420

  Fly   405 ETSTLAIKVALKSLKFYHNYYHIPLVVTTVLALLGWQFY---QLVKLSQNVMAP----HYMRRGY 462
            ......|..|::.|.:||.|..:.|..:.||..:||..|   .::|...::..|    ..:....
Zfish   421 VYCKDLIAQAMEGLSYYHTYDRLFLGSSVVLGFIGWTSYVVLYILKTHASLRKPPTNTSMVTERL 485

  Fly   463 LTWCTIFLASLGLLLGEMVFLQWAPFMTVICLVVPFGVWCMTLAALPQNGGWIFEPLKHLRWIVG 527
            |.|.  ||. :|||:...:.:|.:|:...|..::|..||              :..||..:.:||
Zfish   486 LGWG--FLC-VGLLMALFLLVQSSPWSYYIYSLMPVAVW--------------YAVLKEFKTLVG 533

  Fly   528 -----PA-----------------AVMIASIYCNCPLSLAYILCV------GFYNRRGWLHPSPK 564
                 |:                 .:::.|.:....|||..::..      |||.:..:     |
Zfish   534 LVRSIPSLPLTKCFGYFVLVAFGIELLVMSFFYRAMLSLGLVVLALWPVVSGFYTKAKF-----K 593

  Fly   565 FLAW------LALVLLL---------------GG--------FLWSQKGMQILMTTNYRVVLQAI 600
            .|:|      ||:..||               ||        ||||......||..:.::.:  .
Zfish   594 SLSWTLSCLSLAVFPLLPVVGREPNINYVISAGGLILFNSSSFLWSSWRDSPLMRRDRQLFI--F 656

  Fly   601 SMLVVIVRPCVLNENHKWKVWVINGGILFVAAIGIFLKEMGKPVPLYLFAANWAYLIYAFASVPC 665
            .|:.|.:....|...|.                .:.||:   .:|::....:|:.|:.:|. :|.
Zfish   657 QMVQVALCAYTLTSTHS----------------SLQLKQ---GLPIFNQLVSWSTLVSSFL-IPL 701

  Fly   666 SSRTTPQSRLELIRFNLLTLHVLLSDSYVSLFAQGLIIEYQMGLEVHEKFKEADEDVKILTSSKH 730
            .|.|....||..|..:|..:::|||..:.:||.  |::.:.|...:|   .|.:...:..:|:::
Zfish   702 LSSTRLFHRLLSILMSLTCVYLLLSTGHEALFP--LMLSWLMLAWIH---IEQEAMSRQGSSNRN 761

  Fly   731 LQMCYRFAVSILL--------------YFYA-----SLFGTGHWVGGFTYLANSARLFLPDSSSG 776
            ...|..||.:|.:              ||:.     :.||.|:.....::...|...||...:..
Zfish   762 ELSCIDFAENIDITKVRQLRLDDIRKSYFFVFFIIIAFFGCGNIASINSFDPASVYCFLTVFNPF 826

  Fly   777 LVPLLVLIHLLIPSIVIMASVVALSSFGRQQIRTIFSSLMLICNAVVLFFVVFVPHNAYWPMAHP 841
            ::..|::..:|||.:::|.:..::....:...|::|..:::|.:.:.|.|...|.....|.....
Zfish   827 IMGGLLMWKVLIPFVIVMCTFESIQVSTQLSSRSLFLIVLVISDLMALHFFFLVKDYGSWLDIGT 891

  Fly   842 SVVH-ALLAQLTVILILACESIVT 864
            |:.| .::..:|:.|:|.  |::|
Zfish   892 SISHYVIVMSMTIFLMLL--SVMT 913

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6790	NP_650087.2	GPI_EPT_1	83..331	CDD:293744	94/322 (29%)
CG6790	NP_650087.2	PigN	418..821	CDD:282796	99/485 (20%)
pign	NP_001297009.1	Npp1	11..>282	CDD:224441	80/291 (27%)
		GPI_EPT_1	42..347	CDD:293744	94/322 (29%)
		PigN	433..885	CDD:282796	102/500 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595998
Domainoid	1	1.000	122	1.000	Domainoid score	I5581
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55072
OrthoDB	1	1.010	-	-		D141925at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12250
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.960