Protein Alignment CG6790 and PIGG

DIOPT Version :10

• Sequence 1: NP_650087.2
• Gene: CG6790 / 41388
• FlyBaseID: FBgn0037915
• Length: 897
• Species: Drosophila melanogaster
• Sequence 2: NP_001120650.1
• Gene: PIGG / 54872
• HGNCID: 25985
• Length: 983
• Species: Homo sapiens
• Alignment Length: 1013
• Identity: 194/1013 - (19%)
• Similarity: 341/1013 - (33%)
• Gaps: 316/1013 - (31%)

  Fly    83 PPAADRLVVFLLEGLRADTLFSDNCSGAVYIRDIILRQGLVG--ISKTSVPTLTRSAEVALFAGF 145
            ||...::|:.|::.||.|.:|.......:.....::.:|...  :::...||:|.....||..|.
Human    62 PPLFSKVVIVLIDALRDDFVFGSKGVKFMPYTTYLVEKGASHSFVAEAKPPTVTMPRIKALMTGS 126

  Fly   146 NP----------MPSILPTSNFDTIFNRTLAFDKGA---------------FLRF--------SH 177
            .|          .|::|.    |::..:..|..|..               |:.:        |.
Human   127 LPGFVDVIRNLNSPALLE----DSVIRQAKAAGKRIVFYGDETWVKLFPKHFVEYDGTTSFFVSD 187

  Fly   178 LSDLRRRLTKRACLEKL-----WYANKLVM----LVNLAEVGGA-SPLDIGFQ--------MKLH 224
            .:::...:|:.  |:|:     |  :.|::    |.::..:.|. ||| ||.:        ||:|
Human   188 YTEVDNNVTRH--LDKVLKRGDW--DILILHYLGLDHIGHISGPNSPL-IGQKLSEMDSVLMKIH 247

  Fly   225 NTQRNIRDAYELIEATFNDSKTAYLYTSAHGLTYFGSHGGGSDEEREAPFLLWGAGVKHVTENIT 289
            .:.::......|        ....:....||::..||||..|.||...|.:|           |:
Human   248 TSLQSKERETPL--------PNLLVLCGDHGMSETGSHGASSTEEVNTPLIL-----------IS 293

  Fly   290 SDFVLNNGVGMQLHKLDQIQLAPLMSALIGLPPPVNNLA--ILPQGYMKVSREYARKSVHLNALQ 352
            |.|....|.......:.|..:|..::..:|||.|.:::.  :.|....:..||..| .:|||.:|
Human   294 SAFERKPGDIRHPKHVQQTDVAATLAIALGLPIPKDSVGSLLFPVVEGRPMREQLR-FLHLNTVQ 357

  Fly   353 L----------------LTQAKAIIRLHERGVFHKWLPKDKDLDLQQIAYYQNQMDHLLDMGWRS 401
            |                ..|.|...|||     ..|:         ::...:...:.|.::|  |
Human   358 LSKLLQENVPSYEKDPGFEQFKMSERLH-----GNWI---------RLYLEEKHSEVLFNLG--S 406

  Fly   402 KALETSTLAIKVALKSLKFYHNYYHI-PLVVTTVLALLGWQFYQLVKLSQNVMAPHYMRRGYLTW 465
            |.|.....|:|....||......|.| .::|.||:.|   :...|:.||    .|..:||  ...
Human   407 KVLRQYLDALKTLSLSLSAQVAQYDIYSMMVGTVVVL---EVLTLLLLS----VPQALRR--KAE 462

  Fly   466 CTIFLASLGL-LLGEMVFLQWAPFMTVICLVVPFGVWCMTLAALPQNGGWIFEPLKHLRWIVGPA 529
            ..:.|:|.|. ||..:|.|..:....::|.......:...|:       |:         ..|..
Human   463 LEVPLSSPGFSLLFYLVILVLSAVHVIVCTSAESSCYFCGLS-------WL---------AAGGV 511

  Fly   530 AVMIASIYCNCPLSLAYILCVGFYNRRGWLHPSPKFLAW--LALVLLLG--GFLWSQKGMQILMT 590
            .|:.:::.|.....|..:|..|...|:..:|||.:   |  |.|::|||  |.:.| .|....:.
Human   512 MVLASALLCVIVSVLTNVLVGGNTPRKNPMHPSSR---WSELDLLILLGTAGHVLS-LGASSFVE 572

  Fly   591 TNYRVVLQAISMLVVIVR---------------PC------------------------------ 610
            ..::.....::.|.:.:.               ||
Human   573 EEHQTWYFLVNTLCLALSQETYRNYFLGDDGEPPCGLCVEQGHDGATAAWQDGPGCDVLERDKGH 637

  Fly   611 -------VLNENHKWKV----WVI-----------NGGILFV--AAIGIFLKEMGKPVPLYLFAA 651
                   ||....||.|    |:|           ..|:.:.  ..:|.:|........|.:.||
Human   638 GSPSTSEVLRGREKWMVLASPWLILACCRLLRSLNQTGVQWAHRPDLGHWLTSSDHKAELSVLAA 702

  Fly   652 NWAYLIYAFASVPCSSRTTPQSRLELIRFNLLTLHV----------------------LLSDSYV 694
            ....:::......||    |.|:..| ...||.::.                      ::...:|
Human   703 LSLLVVFVLVQRGCS----PVSKAAL-ALGLLGVYCYRAAIGSVRFPWRPDSKDISKGIIEARFV 762

  Fly   695 SLFAQGLII------------------------EYQMGLEVHEKFKEADEDVKILTSSKHLQ-MC 734
            .:|..|::.                        |...||.:.........::.:|..|..:| :.
Human   763 YVFVLGILFTGTKDLLKSQVIAADFKLKTVGLWEIYSGLVLLAALLFRPHNLPVLAFSLLIQTLM 827

  Fly   735 YRFAVSILLYFYASLFGTGHWVGG--FTYLANSARLFLPDSSSGLVPLLVLIHLLIPSIVIMASV 797
            .:|....|.:..|.:....:|.|.  |.:..||..:...|.|:|.|.|...:.  ||:::
Human   828 TKFIWKPLRHDAAEITVMHYWFGQAFFYFQGNSNNIATVDISAGFVGLDTYVE--IPAVL----- 885

  Fly   798 VALSSFGRQQIRTIFSSLM----------------------LICNAVVLFFVVFVP----HNAYW 836
              |::||......:::|.:                      |||:..|..::|.|.    |...|
Human   886 --LTAFGTYAGPVLWASHLVHFLSSETRSGSALSHACFCYALICSIPVFTYIVLVTSLRYHLFIW 948

  Fly   837 PMAHPSVVHALLAQLTVILILACESIVTIFFRRLNMNR 874
            .:..|.    ||.:...:||.|.   |.:||..::..|
Human   949 SVFSPK----LLYEGMHLLITAA---VCVFFTAMDQTR 979

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6790	NP_650087.2	GPI_EPT_1	83..331	CDD:293744	60/302 (20%)
		PigN	418..821	CDD:461508	96/548 (18%)
PIGG	NP_001120650.1	GPI_EPT_2	62..335	CDD:293748	60/300 (20%)
		PIGO_PIGG	<803..965	CDD:437148	34/174 (20%)