DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6790 and Pigg

DIOPT Version :9

Sequence 1:	NP_650087.2	Gene:	CG6790 / 41388	FlyBaseID:	FBgn0037915	Length:	897	Species:	Drosophila melanogaster
Sequence 2:	NP_001297618.1	Gene:	Pigg / 433931	MGIID:	3576484	Length:	983	Species:	Mus musculus

Alignment Length:	980	Identity:	210/980 - (21%)
Similarity:	350/980 - (35%)	Gaps:	275/980 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    83 PPAADRLVVFLLEGLRADTLFSDNCSGAVYI--RDIILRQGLVG--ISKTSVPTLTRSAEVALFA 143
            ||...::|:.|::.||.|.:|..  .|..|:  ...::.:|...  :::...||:|.....||..
Mouse    62 PPLFSKVVIVLIDALRDDFVFGS--KGVKYMPYTTYLVEKGASHSFVAEAKPPTVTMPRIKALMT 124

  Fly   144 GFNP----------MPSILPTSNFDTIFNRTLAFDKGA---------------FLRF-------- 175
            |..|          .|.:|.    |.:..:..|..|..               |:.:
Mouse   125 GSLPGFVDVIRNLNSPVLLE----DNVLRQAKAAGKRIIFYGDETWVKLFPKHFVEYDGTTSFFV 185

  Fly   176 SHLSDLRRRLTKRACLEKL-----WYANKLVM----LVNLAEVGGA-SPLDIGFQ--------MK 222
            |...::.:.:|:.  |:|:     |  :.|::    |.::..:.|. ||| ||.:        ||
Mouse   186 SDYIEVDKNVTRH--LDKVLKRGDW--DVLILHYLGLDHIGHISGPNSPL-IGHKLSEMDSVLMK 245

  Fly   223 LHNTQRNIRDAYELIEATFNDSKTAYLYTSAHGLTYFGSHGGGSDEEREAPFLLWGAGVKHVTEN 287
            :| |....:|...|:.:..       :....||::..||||..|.||...|.||
Mouse   246 IH-TSLLSKDRETLLPSLL-------VLCGDHGMSETGSHGASSTEEVSTPLLL----------- 291

  Fly   288 ITSDFVLNNGVGMQLHKLDQIQLAPLMSALIGLPPPVNNLA--ILPQGYMKVSREYARKSVHLNA 350
            |:|.|....|.......:.|..||..::..:|||.|.:::.  :.|....|..||..| .:|||.
Mouse   292 ISSAFERKPGDIRHPKHVQQTDLAATLAIGLGLPIPKDSVGSLLFPVIEGKPMREQLR-FLHLNT 355

  Fly   351 LQL----------------LTQAKAIIRLHERGVFHKWLPKDKDLDLQQIAYYQNQMDHLLDMGW 399
            |||                ..|.|...:||     ..|:    .|.|:     :|..|.||.:|
Mouse   356 LQLSKLLQENVPSYEKDPGFEQFKMAEKLH-----GNWV----KLHLE-----ENHSDILLGLG- 405

  Fly   400 RSKALETSTLAIKVALKSLKFYHNYYHI------PLVVTTVLALL----GWQFYQLVKLSQNVMA 454
             :|.|.....|:|....||......|.:      .|:|..||||.    .....:..:|...:::
Mouse   406 -TKVLRHYLGALKTLSLSLSTQVAQYDMYSMAVGTLIVLEVLALFLLSTPHVLCRKAELDVPLLS 469

  Fly   455 PHYMRRGYLTW----------CT-----IFLASLG-LLLGEMVFLQWAPFMTVICLVVPFGVWCM 503
            |.:....||.:          ||     .:|.||. |.:|.::.|..|.|..::..::...:...
Mouse   470 PVFSLLFYLVFLVLSAIHVLVCTSSESSCYLCSLSWLAVGAVMLLVSALFCAILSALIRMVIDST 534

  Fly   504 TLA--ALPQNGGW---------------------IFEPLKHLRW--IVGPAAVMIASIYCN---- 539
            .|.  |...:.||                     .|...:|..|  ::....:.::...|.
Mouse   535 LLKKNAADASSGWSEVNLLLLLGTVGHVLSLGASSFVEEEHQTWYFLINTLCLALSQETCRSYFL 599

  Fly   540 ---------------------CPL--SLAYIL--------CVGFYNRRGWLHPSPKFLAWLA--- 570
                                 |||  |.:|..        .|.....:|    |.|:...||
Mouse   600 GDECEPQRHSHVEQQCVNLLACPLQDSTSYNTPESGTAGKRVSLLEAQG----SCKWWTVLASPW 660

  Fly   571 LVLLLGGFLWS--QKGMQ---------ILMTTNYRVVLQAISMLVVIV------RPCVLNENHKW 618
            ||||....|.|  |.|:|         .|.:::::|.|..::.|.::|      |.|.|......
Mouse   661 LVLLCCRLLRSLNQTGVQGAHRPDFSHWLTSSDHKVQLSGLAALSLVVIFMLVQRRCSLVSKVAL 725

  Fly   619 KVWVINGGILFVAAIGIF---LKEMGKPVPLYLFAANWAYLIYAFASVPCSSRTTPQSRLELIRF 680
            .:.:: |...:.|||||.   .:...|.:...:..|.:   :|.|......:.|....:.::|..
Mouse   726 ALGLL-GVFCYRAAIGIVQFPWQSDNKGISKGIIEARF---VYVFVLGILFTGTKDLLKAQVIAT 786

  Fly   681 NLLTLHVLLSDSYVSLFAQGLIIEYQMGLEVHEKFKEADEDVKILTSSKHLQ-MCYRFAVSILLY 744
            :..|..|.|.:.:     .||::...:.|..|        ::.:|..|..:| :..:|....|.:
Mouse   787 DFKTKTVGLWEMH-----SGLVLLAALLLRPH--------NLPVLAFSLLIQTVMTKFIWKPLRH 838

  Fly   745 FYASLFGTGHWVGG--FTYLANSARLFLPDSSSGLVPLLVLIHLLIPSI-----------VIMAS 796
            ..|.:....:|.|.  |.:..||..:...|.|:|.|.|..  ::.:|:.           |:.||
Mouse   839 DAAEITVMHYWFGQAFFYFQGNSNNIATIDISAGFVGLDT--YMEVPATFLTVFGTYVGPVLWAS 901

  Fly   797 --VVALSSFGRQQI--RTIFSSLMLICNAVVLFFVVFVP----HNAYWPMAHPSVVHALLAQLTV 853
              |..|||.|....  |:.| ...|||:..|..::|.|.    |...|.:..|.:::..:..|..
Mouse   902 HLVYFLSSEGNNSALSRSCF-CYALICSVPVATYIVLVTSLRYHLFIWSVFSPKLLYEGMHLLIT 965

  Fly   854 ILILA 858
            ..|.|
Mouse   966 AAICA 970

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6790	NP_650087.2	GPI_EPT_1	83..331	CDD:293744	66/304 (22%)
CG6790	NP_650087.2	PigN	418..821	CDD:282796	107/529 (20%)
Pigg	NP_001297618.1	GPI_EPT_2	62..335	CDD:293748	66/302 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1524
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810