DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6790 and PIG-N

DIOPT Version :9

Sequence 1:	NP_650087.2	Gene:	CG6790 / 41388	FlyBaseID:	FBgn0037915	Length:	897	Species:	Drosophila melanogaster
Sequence 2:	NP_610549.1	Gene:	PIG-N / 36049	FlyBaseID:	FBgn0033479	Length:	894	Species:	Drosophila melanogaster

Alignment Length:	911	Identity:	285/911 - (31%)
Similarity:	442/911 - (48%)	Gaps:	110/911 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 LWKSKVVLVHLLLLICIMRIFYQSGPLSQLEPQKTLLDMGVPPAADRLVVFLLEGLRADTLFSDN 106
            :|.:..::||:|||..|..|:::|..::.|.|||.||..|:.|.|:|||:.:.:|.|||:.|.:|
  Fly     1 MWIAYALVVHVLLLGSIFVIYFRSPVITGLTPQKHLLYYGLEPPANRLVLIVTDGFRADSFFEEN 65

  Fly   107 CSGAVYIRDIILRQGLVGISKTSVPTLTRSAEVALFAGFNPMPSILPTS------NFDTIFNR-- 163
            |.....:|.|.||:|:||:|:|.|||.||...:.|.||....||.:...      :|||:|||
  Fly    66 CRYVPNLRKIFLREGVVGVSRTRVPTETRPGHITLIAGLYEDPSAVLRGWKSNPIDFDTVFNRSS 130

  Fly   164 -TLAFDKGAFLR-FSHLS------------DL-----------------RRRLTKRACLEKLWYA 197
             |.|:.....|. |||:|            ||                 |.:|..:...|.|..|
  Fly   131 QTYAWGANDVLNVFSHVSNGGEINLRFYNHDLDFSPGYDAYEEDEWVFKRVKLLLQQKREALQRA 195

  Fly   198 NKLVMLVNLAEVGGA----SPLDIGFQMKLHNTQRNIRDAYELIEATFNDSKTAYLYTSAHGLTY 258
            ..:|..::|..:..|    .|....|:..|..|::.:...|:..|..|.|.:||||.|:.||:|.
  Fly   196 QNVVFFLHLLGLDTAGHVHKPGAPKFRRTLEKTEKGVYAIYQEFERVFPDKRTAYLLTADHGMTD 260

  Fly   259 FGSHGGGSDEEREAPFLLWGAGV-KHVTENITSDFVLNN-GVGMQLHKLDQIQLAPLMSALIGLP 321
            .|:||.||..|.:.||:|||||. :.|.:.....|:.|| |..|.||:|:|.||.||||||:||.
  Fly   261 SGAHGSGSPHETDTPFMLWGAGASRAVPKPGGRTFMPNNEGPAMPLHELEQAQLTPLMSALLGLA 325

  Fly   322 PPVNNLAILPQGYMKVSREYARKSVHLNALQLLTQAKAIIRLHERGVFHKWLPKDKDLDLQQIAY 386
            ||:||...||.||:.||:||...:.|:||||||.|..|:.:.|::|.|...|.:...|:.:.|..
  Fly   326 PPMNNFGKLPLGYLNVSKEYEAMAAHVNALQLLEQYVALQKQHKKGFFADILLEYDVLNAEAIKR 390

  Fly   387 YQNQMDHLLDMGWRSKALETSTLAIKVALKSLKFYHNYYHIPLVVTTVLALLGWQFYQLVKLSQN 451
            |::.:..|......|..::.|.:.:..||:.:.:||.||...|:::|....|||.||....||:|
  Fly   391 YKDTIVQLQKKREYSLCIDKSQVIMSQALEGIDYYHGYYRRVLLLSTTSTFLGWMFYIYRLLSRN 455

  Fly   452 VMAPHYM---RRGYLTWCTIFLASLGLLLGEMVFLQWAPFMTVICLVVPFGVWCMTLAALPQNGG 513
            ..:...:   |...:...:|..:.:.|::  .:..|..|......|::|:.||...|.  |.|..
  Fly   456 RASKVELVLERSNKIVRVSIVSSVIVLII--CLLSQGTPLDISFYLLLPYFVWLKALQ--PWNIN 516

  Fly   514 WIFEP--------LKHLRW----IVGPAAVMIASIYCNCPLSLAYIL--CVGFYNRRGWLHPSPK 564
            :...|        |:...|    ::..|.:|:.:.:....::|.:.:  |...:....|  .|..
  Fly   517 FSSSPASAYSVPALQTSMWQLVLLIACAELMVFTFFERRLIALCFCVFACYNSWENFQW--KSRD 579

  Fly   565 FLAWLALVLLLGGF--LWSQKGMQILMTTNYRVVLQAISMLVVIV--------RPCVLNENHKWK 619
            |.:||||||:|..|  |....|.|    ..|   |....::|:..        |.|..|.. |:.
  Fly   580 FFSWLALVLILSCFPLLPLSVGYQ----NGY---LLGAGVIVIFTNSFWNSKSRLCYRNHT-KYS 636

  Fly   620 VWVINGGILFVAAIGIFLKEMGKPVPLYLFAANWAYLIYAFASVPCSSRTTPQSRLELIRFNLLT 684
                |..||....:..:|...|..:|:.|..|:|.||:|||||:..|..:....||..|.|||.:
  Fly   637 ----NALILLQTILCAYLHSNGINIPIPLKLASWLYLVYAFASILLSKESRLDLRLAQIGFNLGS 697

  Fly   685 LHVLLSDSYVSLFAQGLIIEYQMGLEVHEKFKEADEDVKILTSSKHLQMCYRFAVSILLYFYASL 749
            |:..|..||.::|.|.|.||..:.|...              |::..:...|.|.::|||.:.||
  Fly   698 LYATLCTSYEAVFVQLLTIELNISLRAQ--------------SARAERSVLRLAFTLLLYTFFSL 748

  Fly   750 FGTGHWVGGFTYLANSARLFLPDSSSGLVPLLVLIHLLIPSIVIMASVVALSSFGRQQIRTIFSS 814
            ||:|:.....::..|.||.:|...:..::..|||:.||:|.::||:.:.|.|.|.||....||..
  Fly   749 FGSGNIASISSFDPNIARCYLSHFAPFVIMGLVLLKLLVPVVLIMSVIYANSEFVRQHEEQIFIC 813

  Fly   815 LMLICNAVVLFFVVFVPHNAYWPMAHPSVVHALLAQLTVILILACESIVTIFFRRLNMNRCSDWR 879
            |:|||:.:.|.|:..|.:...|.....|:.|.::.::|.:::|      .||:....:.|...|.
  Fly   814 LLLICDVMGLNFLFLVRNQGSWLDIGTSISHFVIMEVTTLVML------VIFYTAKQLLRVIPWE 872

  Fly   880 Q 880
            :
  Fly   873 E 873

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6790	NP_650087.2	GPI_EPT_1	83..331	CDD:293744	107/292 (37%)
CG6790	NP_650087.2	PigN	418..821	CDD:282796	121/429 (28%)
PIG-N	NP_610549.1	Npp1	10..>265	CDD:224441	85/254 (33%)
		GPI_EPT_1	42..335	CDD:293744	107/292 (37%)
		PigN	421..834	CDD:282796	124/444 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45470304
Domainoid	1	1.000	119	1.000	Domainoid score	I1899
eggNOG	1	0.900	-	-		E1_COG1524
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1579
OMA	1	1.010	-	-		QHG55072
OrthoDB	1	1.010	-	-		D141925at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR12250
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	8	7.810