DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6790 and Pigo

DIOPT Version :9

Sequence 1:	NP_650087.2	Gene:	CG6790 / 41388	FlyBaseID:	FBgn0037915	Length:	897	Species:	Drosophila melanogaster
Sequence 2:	XP_038966909.1	Gene:	Pigo / 313341	RGDID:	1309498	Length:	1128	Species:	Rattus norvegicus

Alignment Length:	1102	Identity:	211/1102 - (19%)
Similarity:	345/1102 - (31%)	Gaps:	415/1102 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 YQSGPLSQLEPQKTLLDMGVPPAADRLVVFLLEGLRADTLFSDNCSGAVYIRDIILRQGLVGISK 127
            ||    ||::|..|.:..........|..|:..|        .|.:....:.|.:::|
  Rat   142 YQ----SQVDPPTTTMQRLKALTTGSLPTFIDAG--------SNFASHAIVEDNLIKQ------- 187

  Fly   128 TSVPTLTRSAEVALFAGFNPMPSILPTSNFDTIFNRTLAFDKGAFLRFSHLSDLRRRLTKRACLE 192
                 ||.:.:..:|.|.:....:.|.           ||.:..|....::.||  .......||
  Rat   188 -----LTSAGKRVVFMGDDTWKDLFPG-----------AFSQAFFFSSFNVRDL--HTVDNGILE 234

  Fly   193 KL--------WYANKLVMLVNLAEVGGA----SPLDIGFQMKLHNTQRNIRDAYELIEATFNDSK 245
            .|        |.    |::.:...|...    .|.......||....:.|:.   |||...||
  Rat   235 HLYPTMDSGAWD----VLIAHFLGVDHCGHKHGPHHPEMAKKLSQMDQVIQG---LIERLEND-- 290

  Fly   246 TAYLYTSAHGLTYFGSHGGGSDEEREAPFLLWGAGVKHVTENITSDFVLNNGVGMQLHK-LDQIQ 309
            |..:....||:|..|.|||.|:.|..|...|:            |..||...|..:..: :.||.
  Rat   291 TLLVVAGDHGMTMNGDHGGDSELEVSAALFLY------------SPTVLFPSVPPEEPEVIPQIS 343

  Fly   310 LAPLMSALIGLPPPVNN----LAILPQG--------------------YMKVSREYARKSVHLNA 350
            |.|.::.|:|||.|..|    :|.|..|                    ..:||      ::::||
  Rat   344 LVPTLALLLGLPIPFGNIGEVMAELFSGGSGGGSSRGDGDASHPDSPALAQVS------ALYINA 402

  Fly   351 LQ----LLTQAKAIIRLHERGVFHKWLPKDKDLDLQQIAYYQNQMDHLLDMGWRSKALETSTLAI 411
            .|    |.|.:.|...||.     |.|.:.::|..:..|.||:.:.|..:   ...||.:.|...
  Rat   403 QQVSRFLHTYSAATQDLHV-----KELRRLQELFSKASARYQHLLQHPRE---AEAALSSLTADF 459

  Fly   412 KVALKSLKFYHNYYHIPLVVTTVLALLGWQFYQLVKL-----------------SQNVMAPHYMR 459
            :..|:..:              .:.:..|..:.||::                 ||..:||.::.
  Rat   460 QQFLRGAR--------------AVCIESWARFSLVRMAGGAALLAAACLLCLLASQLAVAPGFLF 510

  Fly   460 RGY--------LTWCTIF------------------LASLGLLLGEM--VFLQW------APFMT 490
            |..        |||..::                  :|:.|.||..:  .:|.|      ||.
  Rat   511 RPLLLIPVAWGLTWTLLYAGVSVTTGSKLDPVVLGAVAAAGSLLPFLWKAWLSWGSKRPLAPL-- 573

  Fly   491 VICLVVPFGVWCMTLAALPQ-----------------NGGWIFEPLKHLRW---IVGPAAVMIAS 535
               |.||..|..:.|..|..                 .|..|...:..|.|   ::.|..:..:.
  Rat   574 ---LPVPRPVLALLLIRLATFFSDSFVVAEARATPFLLGSLILFLVAQLHWEGQLLPPKLLTTSR 635

  Fly   536 IYCNCPL-------SLAYILCVG---FYNRRGWLH------PSPKFLAWLA-LVLLLGG---FLW 580
            :..:.|.       :.|.:|.:|   |....|..|      |:.:...||: |..::||   .||
  Rat   636 LGSSAPTAPPRHSGTHALLLGIGLLLFTRLAGLFHRCPEETPACRSSPWLSPLASMVGGRAKNLW 700

  Fly   581 SQKGMQILMTTNYRVVLQAISMLVVIVR-------------PCVLNENHKWKV----------WV 622
                        |...:.|:..|:..||             |.||..  :|.:          |.
  Rat   701 ------------YGACVGALVALLAAVRLWLRRYGNLKSPEPPVLFV--RWGLPLMVLGTAAYWA 751

  Fly   623 INGG----------------------ILFVAAIGIFLKEMGKPVPLYLFA----ANWAYLIYAFA 661
            :..|                      ::.:||.|:.|. :.:||.:.:.|    :....::..|:
  Rat   752 LASGAEEVPPRLRALVAGASAVLPRAVMGLAASGLMLL-LWRPVTVLVKAGAATSRTRTILTPFS 815

  Fly   662 SVPCSSR----TTP----------QSRLE----------------------------LIRFNLLT 684
            ..|.|..    ..|          |.|||                            |:.|.||.
  Rat   816 GPPTSQADLDYVVPQIYRHMQEEFQGRLERTRAQGPITVAAYQLGSVYSAAMVTALILLAFPLLL 880

  Fly   685 LHV-LLSDSYVSLFAQGLIIEYQMGLEVHEKFKEADEDVKILTSSKHLQMCYRFAVSILL---YF 745
            ||| .:|..::.||.|..::.:.:.           ....:.|......|....:..:||   .|
  Rat   881 LHVERVSLVFLLLFLQSFLLLHLLA-----------AGTPVATPGPFTVMWQAVSAWVLLATQTF 934

  Fly   746 YAS----LFGTGHWVGGF----------TYL------AN---SARLFLPDSSSGLV--PLLVLIH 785
            |::    :|...||...|          |:|      ||   |..||...||...|  |||:|..
  Rat   935 YSTGHQPVFSAIHWHAAFVGFPDGHGSSTWLPALLVGANTFASHLLFAALSSPEAVGCPLLLLWP 999

  Fly   786 LL-----------IPSIVIMASV-----------------------VALSSFGRQQIRTIFSSLM 816
            .|           :|.....|.|                       .||...|.:.:..:.:.::
  Rat  1000 FLCERQGPKKRQSLPGSESEARVRPEEEQEEPLMEMRLRDAPHHFNAALLQLGLKYLFVLGAQIL 1064

  Fly   817 LICNAVVLFFVVFVPHNAYWPMAHPS--------VVHALLAQLTVILILACESIVTIFFRRL 870
                |..|...:...|...|.:..|.        :|.::...|.:.|::..:..|:.:|::|
  Rat  1065 ----ACALAASILRRHLMVWKVFAPKFIFEAIGFIVSSVGLLLGIALVMRVDGAVSSWFKKL 1122

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6790	NP_650087.2	GPI_EPT_1	83..331	CDD:293744	58/264 (22%)
CG6790	NP_650087.2	PigN	418..821	CDD:282796	113/647 (17%)
Pigo	XP_038966909.1	GPI_EPT_3	85..365	CDD:293747	63/280 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910