Protein Alignment CG6790 and its8

DIOPT Version :10

• Sequence 1: NP_650087.2
• Gene: CG6790 / 41388
• FlyBaseID: FBgn0037915
• Length: 897
• Species: Drosophila melanogaster
• Sequence 2: NP_595248.1
• Gene: its8 / 2541199
• PomBaseID: SPBC839.08C
• Length: 935
• Species: Schizosaccharomyces pombe
• Alignment Length: 1002
• Identity: 217/1002 - (21%)
• Similarity: 379/1002 - (37%)
• Gaps: 254/1002 - (25%)

  Fly    48 VLVHLLLLICIMRIFYQSGPLSQLEPQKTLLDMGVPPAADRLVVFLLEGLRADTLF---SDNCSG 109
            :|.|::.|..|..|::.: ||.....|   ...|..| |.||.:.:.:|||.|.|.   |:...|
pombe    10 ILFHVVFLKSIFDIYFVT-PLIHGMKQ---YSAGEAP-AKRLFLIVGDGLRPDKLLQPHSEKVIG 69

  Fly   110 ------AVYIRDIILRQGLVGISKTSVPTLTRSAEVALFAGF-------------NPMPSILPTS 155
                  |.::|.||...|..|:|.|.|||.:|...|||.|||             ||:
pombe    70 EEQTYAAPFLRSIIQNNGTFGVSHTRVPTESRPGHVALIAGFYEDVSAVTKGWKKNPV------- 127

  Fly   156 NFDTIFNRTL------------AFDKGA--------FLRFSHLSD---------------LRRRL 185
            |||::||::.            .|.:||        |:..|.|.|               |...|
pombe   128 NFDSVFNQSRHTYSFGSEDILPMFSEGASDPSRVDTFMYSSELEDFSSNGIVLDEWVFDRLDELL 192

  Fly   186 TKRACLEKLW---YANKLVMLVNLAEVG----GASPLDIGFQMKLHNTQRNIRDAYELIEATF-N 242
            .:....::||   :.:|:|..::|..:.    ...|..:.:...:......|::..:.:...: |
pombe   193 AQSLEDKELWDMLHRDKIVFFLHLLGIDTIGHNKHPDSVEYVENIQYIDGKIQELVDKMNNYYNN 257

  Fly   243 DSKTAYLYTSAHGLTYFGSHGGGSDEEREAPFLLWGAGVKHVTE-------------NITSDFVL 294
            |..:::::|:.||::.|||||.|:.:....|.:.||||::..|.             |:|
pombe   258 DGASSWVFTADHGMSDFGSHGDGNLDNTRTPIIAWGAGIQSPTHEKNYGHDEYSLPWNLT----- 317

  Fly   295 NNGVGMQLHKLD--QIQLAPLMSALIGLPPPVNNLAILPQGYMKVSREYARKSVHLNALQLLTQ- 356
                  ::.::|  |..:|.|||.|:||..|||::..:|..|:..|.....:...:|||::..|
pombe   318 ------EIKRIDIQQADIAALMSYLVGLNFPVNSVGQIPLDYLDCSSRRKAEVALMNALEIGEQY 376

  Fly   357 -AKAIIRLHERGVFHKWLPKDKDLDLQQIAYYQNQMDHLLDMGWRSKALETSTLAIKVALKSLKF 420
             .|:..:......|..:.|.....::|  |.:.|.:...::.|....|:|......:..|..|::
pombe   377 NLKSASKDQTSIFFRPYSPLRNYTEVQ--ASFYNSVIADIESGEYEIAIEHCFHFSQTVLSGLRY 439

  Fly   421 YHNYYHIPLVVTTVLALLGWQFYQL-------VKLSQNVMAP-HYMRR-----GYLTWCTIFLAS 472
            ...|..:.|........|.|..|.:       ::.|..::.| ..::|     .:|..|..|...
pombe   440 LQRYDWLLLRSIVFFGYLSWIGYVICFVFSLNIEPSSKIVKPVSVVKRVAFNIPFLLICIFFYIQ 504

  Fly   473 ------LGLLLGEMVFLQWAPFMTVICLVVP---FGVWCMTLAALPQNGGWIFEPLKHLRWIVGP 528
                  .|..|...:|||      :|..:.|   .|.......|..::|   |..||
pombe   505 SSPPFYYGYALFPTIFLQ------LIHSIFPNTKLGFKNFLTVAKQKHG---FSLLK-------- 552

  Fly   529 AAVMIASIYCNCPLSLAYILCVGFYNRRG------------W-LHPSPKF------LAWLALVLL 574
              ::..|:   |.|.|...:...:::|.|            | ||....|      ::|..|..|
pombe   553 --ILFISL---CILCLLQFIVYSYFHREGFSVILMGLAAWPWLLHADYAFSHKTISVSWSVLTSL 612

  Fly   575 L-------------------GGFLWSQKGMQILM------------TTNYRVVLQAISMLVVIVR 608
            |                   |||..|..|:..::            .||.::|||.:.::..:
pombe   613 LCFFTILPVNKKESLLFIFAGGFAMSVAGVFYILYRRNQAFQYSSTVTNKQLVLQVLIIMATV-- 675

  Fly   609 PCVLNENHKWKVWVINGGILFVAAIGIFLKEMGKPVP-----LYLFAANWAYLIYAFASVPCSSR 668
            |..|......:..:....||.:.|.|:|:.....|..     .:.|....|.|...|:...|
pombe   676 PVTLKIADSLQRNIAIPPILRLVAFGLFITSYIIPSHHIRSCKHYFLDRLAILFLTFSPTMC--- 737

  Fly   669 TTPQSRLELIRFNLLTLHVLLSDSYVSLFAQGLIIEYQMGLEVHEKFKEADEDVKILTSSK---- 729
                               :||.|:.:||...|.|...:.:|:..:.::..|.:....|.|
pombe   738 -------------------MLSISFEALFYVVLFITLGLWMELETELQKYTEQLHPEYSRKKDAK 783

  Fly   730 -HLQMCYRFAVSILLYFY----ASLFGTGHWVGGFTYLANSARLFLPDSSSGLVPLLVLIHLLIP 789
             ||.:.:   :.|.|:||    .:.||||:.....|:..:|.:.|:|..:......|::..:|:|
pombe   784 FHLSLSH---IRISLFFYIFINVAFFGTGNVASLSTFALDSVKRFIPVFNPVTQGALLMYTILVP 845

  Fly   790 SIVIMASVVALSS--FGRQQIRTIFSSLMLICNAVVLFFVVFVPHNAYWPMAHPSVVHALLAQLT 852
            .|.:.|:...::.  .|.||: |.|.::.: .:.|.:.|...|.....|.....|:.|..::...
pombe   846 FIALSAAFGIMNKRLGGIQQV-TFFLAVGM-ADIVTINFFYLVKDEGSWKDIGVSISHFCISNFL 908

  Fly   853 VILILA--------CESIVTIFFRRLN 871
            ::.|.|        |::|......::|
pombe   909 ILFITALEHASAILCKNITYTIHEKVN 935

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6790	NP_650087.2	GPI_EPT_1	83..331	CDD:293744	83/327 (25%)
		PigN	418..821	CDD:461508	97/490 (20%)
its8	NP_595248.1	GPI_EPT_1	40..350	CDD:293744	83/328 (25%)
		PigN	436..891	CDD:461508	100/505 (20%)