DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6790 and PIGN

DIOPT Version :9

Sequence 1:	NP_650087.2	Gene:	CG6790 / 41388	FlyBaseID:	FBgn0037915	Length:	897	Species:	Drosophila melanogaster
Sequence 2:	XP_011524191.1	Gene:	PIGN / 23556	HGNCID:	8967	Length:	970	Species:	Homo sapiens

Alignment Length:	996	Identity:	249/996 - (25%)
Similarity:	418/996 - (41%)	Gaps:	227/996 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 VLVHLLLLICIMRIFYQSGPLSQLEPQKTLLDMGVPPAADRLVVFLLEGLRADTLF---SDNCSG 109
            :|:|.:....|..|::.|..:..:.||.|.|    ||.|.|||:|:.:|||||.|:   .:..|.
Human     9 LLIHFVFFASIFDIYFTSPLVHGMTPQFTPL----PPPARRLVLFVADGLRADALYELDENGNSR 69

  Fly   110 AVYIRDIILRQGLVGISKTSVPTLTRSAEVALFAGF-------------NPMPSILPTSNFDTIF 161
            |.:||:||:.:|..|||.|.|||.:|...|||.|||             ||:       .||::|
Human    70 APFIRNIIMHEGSWGISHTRVPTESRPGHVALIAGFYEDVSAVAKGWKENPV-------EFDSLF 127

  Fly   162 NRTL------------AFDKGA--------------------------FLRFSHLSDLRRRLTKR 188
            |.:.            .|.|||                          ...|.::.|........
Human   128 NESKYTWSWGSPDILPMFAKGASGDHVYTYSYDAKREDFGAQDATKLDTWVFDNVKDFFHHARNN 192

  Fly   189 ACLEKLWYANKLVMLVNLAEV---GGA-SPLDIGFQMKLHNTQRNIRDAYELIEATF-----NDS 244
            ..|.......|:|..::|..:   |.| .|....::   ||.:: :.|..:.|.:.|     ||.
Human   193 QSLFSKINEEKIVFFLHLLGIDTNGHAHRPSSRDYK---HNIKK-VDDGVKEIVSMFNHFYGNDG 253

  Fly   245 KTAYLYTSAHGLTYFGSHGGGSDEEREAPFLLWGAGVKH---VTENITSDFVLNNGVGMQLHKLD 306
            ||.:::||.||:|.:||||.|...|...|.:.||||:|:   |:.....|..|.........:||
Human   254 KTTFIFTSDHGMTDWGSHGAGHPSETLTPLVTWGAGIKYPQRVSAQQFDDAFLKEWRLENWKRLD 318

  Fly   307 --QIQLAPLMSALIGLPPPVNNLAILPQGYMKVSREYARKSVHLNALQLLTQAKAIIRLHERG-- 367
              |..:||||::|||:|.|:|::.|||..|:..:..:..:|:..||:|:|.|.|  :::.::.
Human   319 VNQADIAPLMTSLIGVPFPLNSVGILPVDYLNNTDLFKAESMFTNAVQILEQFK--VKMTQKKEV 381

  Fly   368 ----VF--HKWLPKDKDLDLQQIA--YYQN-QMDHLLDMGWRSKALETSTLAIKVALKSLKFYHN 423
                :|  .|.|...|..::.:.|  |.:: :.|.::.:   .|.|      |.:|||.|.:||.
Human   382 TLPFLFTPFKLLSDSKQFNILRKARSYIKHRKFDEVVSL---CKEL------IHLALKGLSYYHT 437

  Fly   424 YYHIPLVVTTVLALLGWQFY----------QLVK-LSQNVMAPHYMRRGYLTWCTIFLASLGLLL 477
            |....|.|..|:..:||..|          .|:| :|:.|..|     .:|..|: |:| :|:|:
Human   438 YDRFFLGVNVVIGFVGWISYASLLIIKSHSNLIKGVSKEVKKP-----SHLLPCS-FVA-IGILV 495

  Fly   478 GEMVFLQWAPFMTVICLVVPFGVWCMTLAALPQNGGWIFE----PLKH-----LRWIVGPAAVMI 533
            ...:.:|..|:...:..::|..:|...|.........:..    ||.|     |.:.:|...:::
Human   496 AFFLLIQACPWTYYVYGLLPLPIWYAVLREFQVIQDLVVSVLTYPLSHFVGYLLAFTLGIEVLVL 560

  Fly   534 ASIYCNCPLSLAYILCVGF-------YNRRGWLHPSPKFLAWLALVLLLGGF-LWSQKGMQILMT 590
            :..|       .|:|..|.       :..|.|.......|:|....|||..| |....|.:
Human   561 SFFY-------RYMLTAGLTAFAAWPFLTRLWTRAKMTSLSWTFFSLLLAVFPLMPVVGRK---- 614

  Fly   591 TNYRVVLQAISMLVVIVRPCVLNENHKWKVWVINGGILF--------VAAIGI-------FLKEM 640
            .:..:|:.| .:||:::..||:....|.|...|...:|.        |.::.:       .|::.
Human   615 PDISLVMGA-GLLVLLLSLCVVTSLMKRKDSFIKEELLVHLLQVLSTVLSMYVVYSTQSSLLRKQ 678

  Fly   641 GKPVPLYLFAANWAYLIYAFASVPCSSRTTPQSRLELIRFNLLTLHVLLSDSYVSLFAQGLIIEY 705
            |  :||.....:||.|..:.. ||..|......||..|..:|::.::|||..|.:||.  |::..
Human   679 G--LPLMNQIISWATLASSLV-VPLLSSPVLFQRLFSILLSLMSTYLLLSTGYEALFP--LVLSC 738

  Fly   706 QMGLEVH---EKFKEADEDVK-ILTSSKHLQMCY---------------RFAVSILLYFYASLFG 751
            .|.:.::   |..:::....| .|||   :|..|               |.|..::.:...:.||
Human   739 LMFVWINIEQETLQQSGVCCKQKLTS---IQFSYNTDITQFRQLYLDDIRRAFFLVFFLVTAFFG 800

  Fly   752 TGHWVGGFTYLANSARLFLPDSSSGLVPLLVLIHLLIPSIVIMASVVA------LSSFGRQQIRT 810
            ||:.....::...|...||...|..::..|::..:|||.:::|.:..|      |||.....|..
Human   801 TGNIASINSFDLASVYCFLTVFSPFMMGALMMWKILIPFVLVMCAFEAVQLTTQLSSKSLFLIVL 865

  Fly   811 IFSSLM----------------------LICNAVVLFFVVFVPHNAYWPMAHP----SVVHALLA 849
            :.|.:|                      |.|.|.:..::...| |..|.::.|    :::||:.|
Human   866 VISDIMALHFFFLVKDYGSWLDIGTRQLLACTAWLFMYISASP-NRLWMLSDPGLDLNLLHAIRA 929

  Fly   850 QLTVILILACESIVTIFFRRL 870
            .::..:|:...:|..:|...|
Human   930 CISHYVIVMSMTIFLVFLNGL 950

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6790	NP_650087.2	GPI_EPT_1	83..331	CDD:293744	96/315 (30%)
CG6790	NP_650087.2	PigN	418..821	CDD:282796	109/492 (22%)
PIGN	XP_011524191.1	Npp1	7..>280	CDD:224441	82/285 (29%)
		GPI_EPT_1	40..345	CDD:293744	96/315 (30%)
		PigN	431..884	CDD:282796	107/479 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159765
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1579
OMA	1	1.010	-	-		QHG55072
OrthoDB	1	1.010	-	-		D141925at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12250
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.910