DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6790 and pign-1

DIOPT Version :9

Sequence 1:	NP_650087.2	Gene:	CG6790 / 41388	FlyBaseID:	FBgn0037915	Length:	897	Species:	Drosophila melanogaster
Sequence 2:	NP_001249296.1	Gene:	pign-1 / 171881	WormBaseID:	WBGene00021840	Length:	912	Species:	Caenorhabditis elegans

Alignment Length:	995	Identity:	231/995 - (23%)
Similarity:	389/995 - (39%)	Gaps:	244/995 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 WKSKV--VLVHLLLLICIMRIFYQSGPLSQLEPQKTLLDMGVPP--------AADRLVVFLLEGL 97
            ||..:  :.|||:|:..|..::|.| ||..          |:||        .|.|:.:...:||
Worm     3 WKFLIASITVHLVLIYSIFDVYYTS-PLVH----------GIPPQFINSQEAPAKRIFIISADGL 56

  Fly    98 RADTLFSDNCSGAVYIRDII-LRQGLVGISKTSVPTLTRSAEVALFAGF-------------NPM 148
            |.|| |:.....:.|:..|: .|:|:.|:|::.:||.:|...||:|||.             ||:
Worm    57 RYDT-FNKYPDKSPYLHSIMNERKGIYGLSRSHIPTESRPGHVAIFAGITEDISAVAKGWKKNPV 120

  Fly   149 PSILPTSNFDTIFNRT--------------------------------------LAFDKGAFLRF 175
                   .||::|||:                                      ...||..|..|
Worm   121 -------QFDSVFNRSSYSWMWGSPDIVNLFDDLPNAESFSYSADEEDFASKDASNLDKWVFEHF 178

  Fly   176 SHLSDLRRRLTKRACLEKLWYANKLVMLVNLAEVG----GASPLDIGFQMKLHNTQRNIRDAYEL 236
            .:.  |....|..|..:|: ...|.:..::|..:.    |..|:...:...:......|.....|
Worm   179 ENF--LETAKTDEALNDKM-REQKSIFFLHLLGIDTNGHGNKPMSRQYIDNIKVVDSGIEKVQHL 240

  Fly   237 IEATFNDSKTAYLYTSAHGLTYFGSHGGGSDEEREAPFLLWGAGVKHVTENITSDFVLNNGVGMQ 301
            ::|.|.|.|||:|:||.||:|.:||||.|||:|...||:.||||||.               |..
Worm   241 VDAFFGDHKTAWLFTSDHGMTDWGSHGAGSDDEVLTPFVAWGAGVKQ---------------GGP 290

  Fly   302 LHKLDQIQLAPLMSALIGLPPPVNNLAILPQGYM-KVSREYARKSVHLNALQLLTQAKAIIRLHE 365
            ...|:||.||||:|||||.|.|||::.|||...| .....|..|::..|..||..|...:.....
Worm   291 KLDLNQIDLAPLISALIGCPIPVNSMGILPVQMMNSKGSSYEFKAIEANFKQLKEQIIFLKNAKS 355

  Fly   366 RGVFHKWLPK--DKDLDLQQIAYYQNQMDHLLDMGWRSKALETSTLAIKVAL--KSLKFYHNYYH 426
            |.::.:...|  ||.::..:....|...|       |..::.||..|....|  :::.|||.|..
Worm   356 RRLWFRQFEKFGDKAMESLRTTLAQLGRD-------RRFSVATSLFADNAHLMKEAIVFYHRYDR 413

  Fly   427 IPLVVTTVLALLGWQFYQLV---------KLSQNVMAPHYMRRGYLTWCTIFLASLGLLLGEMVF 482
            ..|......:.:.|  ..||         |.:.:::.||::....|....:|.|...|.:.:.::
Worm   414 QMLGAAVSCSFVAW--IALVVSFLHNSTSKENLSLLVPHHLFIIPLACSLLFTAYCSLSMTQTIY 476

  Fly   483 LQWAPFMTVIC-----LVVPFGVWCMTLAALPQNGGWIFEPL------KHLRWIVG---PAAVMI 533
            :....::..|.     |..........|:|.|.   |:.:.|      |.....||   ...:.:
Worm   477 IILPIYLISILENHSKLTQRIREHVKALSAQPD---WLNKVLSVEVFVKPFLGFVGFSITICIFV 538

  Fly   534 ASIYCNCPLSLAYILCVG---FYNRRGWLHPSPKFLA--WLALVLLL------------------ 575
            .:......|:..::|.:.   ||:     ||...:.:  ||.|.|:|
Worm   539 LTFMDRAFLAAVFVLLMALPQFYS-----HPIVSYWSKTWLTLCLVLCIFPFLPAVGVSTHIPLC 598

  Fly   576 ------GGFLWSQKGMQILMTTNYRVVLQAISMLVVIVRPCVLNENHKWKVWVINGGI-LFVAAI 633
                  ..||..:...:..:|.     :|.:..|::.|:...     .:.:.|:|.|. .|.|.:
Worm   599 ILSPIITAFLCHRLSRRSCLTR-----IQRMLELMIYVQSAT-----AFMIAVVNYGFEKFAATV 653

  Fly   634 GIFLKEMGKPVPLYLFAANWAYL---IYAFASVPCSSRTTPQSRLELIRFNLLTLHV----LLSD 691
            ...:.         |...|..:.   :.|..|:.|.|.       ..||..||...:    |||.
Worm   654 NCSMD---------LLDLNPTFCDCSVVAHGSISCGSS-------NCIRLMLLCEKIVPYSLLSI 702

  Fly   692 SYVSLFAQGLIIEYQMGLEVHEKFKEADEDVKIL---------TSSKHLQMCYRFAVSILLYFYA 747
            ||.|||.  ||....:.|.|..:|... .||::|         ::.:::::  |..|..:.:...
Worm   703 SYESLFM--LIFLVLLTLFVRFEFGHL-SDVELLQLKVDSTKISTGEYVEL--RRTVVCVSFVLC 762

  Fly   748 SLFGTGHWVGGFTYLANSARLFLPDSSSGLVPLLVLIHLLIPSIVIMASVVALSSFGRQQIR--- 809
            .|||||::....::..::..||:...|...:.:|:::.||||.:::.::..::..|.::.|:
Worm   763 PLFGTGNFASINSFNPSTLNLFISVFSPFTMAILLILKLLIPILLVTSAFASIVRFDQESIQRLC 827

  Fly   810 ---TIFSSLMLICNAVVLFFVVFVPHNAYW---PMAHPSVVHALLAQLTVILILACESIVTIF-F 867
               .||:..|.:|      |...:.....|   .|:....:.::...|.::|:|:..|.:..| |
Worm   828 CFSLIFTDFMSMC------FFHQLRDEGSWLDIGMSISQFIVSMCISLALLLLLSISSHLMAFEF 886

  Fly   868 RRLNMNRCSDWRQEADEFES 887
            |:....|.   .||.:...|
Worm   887 RKFPGKRN---HQEIESISS 903

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6790	NP_650087.2	GPI_EPT_1	83..331	CDD:293744	91/311 (29%)
CG6790	NP_650087.2	PigN	418..821	CDD:282796	94/477 (20%)
pign-1	NP_001249296.1	GPI_EPT_1	42..320	CDD:293744	89/303 (29%)
pign-1	NP_001249296.1	PigN	404..850	CDD:368221	95/492 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160167299
Domainoid	1	1.000	94	1.000	Domainoid score	I4699
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55072
OrthoDB	1	1.010	-	-		D141925at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12250
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.960