DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6790 and Pigg

DIOPT Version :9

Sequence 1:	NP_650087.2	Gene:	CG6790 / 41388	FlyBaseID:	FBgn0037915	Length:	897	Species:	Drosophila melanogaster
Sequence 2:	XP_003751363.1	Gene:	Pigg / 100910143	RGDID:	1560335	Length:	986	Species:	Rattus norvegicus

Alignment Length:	1016	Identity:	221/1016 - (21%)
Similarity:	358/1016 - (35%)	Gaps:	315/1016 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    83 PPAADRLVVFLLEGLRADTLFSDNCSGAVYI--RDIILRQGLVG--ISKTSVPTLTRSAEVALFA 143
            ||...::|:.|::.||.|.:|..  .|..|:  ...::.:|...  :::...||:|.....||..
  Rat    62 PPLFSKVVIMLIDALRDDFVFGS--KGVKYMPYTTYLVEKGASHSFVAEAKPPTVTMPRIKALMT 124

  Fly   144 GFNP----------MPSILPTSNFDTIFNRTLAFDKGA---------------FLRF-------- 175
            |..|          .|.:|.    |.:..:..|..|..               |:.:
  Rat   125 GSLPGFVDVIRNLNSPVLLE----DNVIRQAKAAGKRIIFYGDETWVKLFPKHFVEYDGTTSFFV 185

  Fly   176 SHLSDLRRRLTKRACLEKL-----WYANKLVM----LVNLAEVGGA-SPLDIGFQ--------MK 222
            |...::...:|:.  |:|:     |  :.|::    |.::..:.|. ||| ||.:        ||
  Rat   186 SDYIEVDNNVTRH--LDKVLRRGDW--DVLILHYLGLDHIGHISGPNSPL-IGHKLSEMDSVLMK 245

  Fly   223 LHNTQRNIRDAYELIEATFNDSKTAYLYTSAHGLTYFGSHGGGSDEEREAPFLLWGAGVKHVTEN 287
            :| |....:|...|:.:..       :....||::..||||..|.||...|.||
  Rat   246 IH-TSLLSKDRETLLPSLL-------VLCGDHGMSETGSHGASSTEEVSTPLLL----------- 291

  Fly   288 ITSDFVLNNGVGMQLHKLDQIQLAPLMSALIGLPPPVNNLA--ILPQGYMKVSREYARKSVHLNA 350
            |:|.|....|.......:.|..||..::..:|||.|.:|:.  :.|....|..||..| .:|||.
  Rat   292 ISSAFERKPGDVRHPKHVQQTDLAATLAIGLGLPIPKDNVGSLLFPVIEGKQMREQLR-FLHLNT 355

  Fly   351 LQL----------------LTQAKAIIRLHERGVFHKWLPKDKDLDLQQIAYYQNQMDHLLDMGW 399
            |||                ..|.|...|||     ..|:    .|.|:     :|..|.||.:|
  Rat   356 LQLSKLLQENIPAYEKDPGFEQFKMAERLH-----GNWV----KLHLE-----ENHSDILLGLG- 405

  Fly   400 RSKALETSTLAIKVALKSLKFYHNYYHI-PLVVTTVLALLGWQFYQLVKLSQNVMAPHYM-RRGY 462
             :|.|.....|:|...:||.....:|.| .:.|.|::.|   :...|..||    .||.: |:..
  Rat   406 -TKVLRQYLGALKTLSQSLSTQVAHYDIYSMAVGTLMVL---EVLTLFLLS----TPHVLCRKAE 462

  Fly   463 LTWCTIFLASLGLLLGEMVFLQWAPFMTVIC--------------------LVVPFGVWCMTLAA 507
            |.  ...|:.:..||..::||..:....::|                    :|:...::|..|:|
  Rat   463 LD--VPLLSPVFSLLFYLIFLVLSAIHVLVCTSSESSCYLCNLPWLAAGAVMVLVSALFCAILSA 525

  Fly   508 LPQ---------------NGGWIFEPLKHLRWIVGPAAVMIASIYCN-------------CPLSL 544
            |.:               :.||....|..|...||....:.||.:..             | |:|
  Rat   526 LIRMVTDGTLLRKNATVASSGWSEVNLLLLLGTVGHVLSLGASSFVEEEHQTWYFLINTLC-LAL 589

  Fly   545 AYILCVGFY-----------------------------------------NRRGWL---HPSPKF 565
            :...|..::                                         .:|..|   |.|.|:
  Rat   590 SQETCRSYFLGDDCEPQHHFQVEQKCVNVLACTLQDSTSCSTPESESDTAGKRASLLEAHRSCKW 654

  Fly   566 LAWLA---LVLLLGGFLWS--QKGMQ---------ILMTTNYRVVLQ---AISMLVVIV---RPC 610
            ...||   |||:....|.|  |.|:|         .|.:::::|.|.   |:|::|:.:   :.|
  Rat   655 WTVLASPWLVLICCRLLRSLNQTGVQGAHRPDFSHWLTSSDHKVHLSGLAALSLVVIFILVQKGC 719

  Fly   611 VLNENHKWKVWVINGGILFVAAIGIFL-------KEMGKPVPLYLFAANWAYLIYAFASVPCSSR 668
            .|.......:.:: |...:.|||||.|       |.:.|.:       ..|..:|.|......:.
  Rat   720 SLVSKVALALGLL-GVFCYRAAIGIVLFPWQPDNKGISKGI-------TEARFVYVFVLGILFTG 776

  Fly   669 TTPQSRLELIRFNLLTLHVLLSD---SYVSLFA--QGLIIEYQMGLEVHEKFKEADEDVKILTSS 728
            |.          :||...|:.:|   ..|.|:.  .||::...:.|..|        ::.:|..|
  Rat   777 TK----------DLLKAQVIAADFKTKIVGLWEIHSGLVLLAALLLRPH--------NLPVLAFS 823

  Fly   729 KHLQ-MCYRFAVSILLYFYASLFGTGHWVGG--FTYLANSARLFLPDSSSGLVPLLVLIHLLIPS 790
            ..:| :..:|....|.:..|.:....:|.|.  |.:..||..:...|.|:|.|.|..  ::.:|:
  Rat   824 LLIQTVMTKFIWKPLRHDAAEVTVMHYWFGQAFFYFQGNSNNIATIDISAGCVGLET--YMEVPA 886

  Fly   791 I-----------VIMAS--VVALSSFGRQ---QIRTIFSSLMLICNAVVLFFVVFVP----HNAY 835
            .           |:.||  |..|||.|..   ..|..| ...|||:..|..::|.|.    |...
  Rat   887 TFLTVFGTYVGPVLWASHLVYFLSSEGNNGSALSRACF-CYALICSVPVATYIVLVTSLRYHLFI 950

  Fly   836 WPMAHPSVVHALLAQLTVILILACESIVTIFFRRLNMNRCS 876
            |.:..|.:::..:..|....|.|       .|...|..|.|
  Rat   951 WSVFSPKLLYEGMHLLITAAICA-------VFTATNQTRHS 984

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6790	NP_650087.2	GPI_EPT_1	83..331	CDD:293744	67/304 (22%)
CG6790	NP_650087.2	PigN	418..821	CDD:282796	112/547 (20%)
Pigg	XP_003751363.1	GPI_EPT_2	62..335	CDD:293748	67/302 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1524
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810