DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6790 and pigg

DIOPT Version :9

Sequence 1:	NP_650087.2	Gene:	CG6790 / 41388	FlyBaseID:	FBgn0037915	Length:	897	Species:	Drosophila melanogaster
Sequence 2:	XP_005173129.1	Gene:	pigg / 100538291	ZFINID:	ZDB-GENE-141215-6	Length:	972	Species:	Danio rerio

Alignment Length:	1094	Identity:	208/1094 - (19%)
Similarity:	369/1094 - (33%)	Gaps:	360/1094 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MKLALLQTFLWCFFSVVVNVSFVLYRRLTYRLVGKVQVLMELWKSKVVLVHLLLLICIMRIFYQS 65
            :::..:..||..||.|.|..||..                   ||||..:
Zfish    15 LEIVSIALFLRGFFPVPVKSSFSA-------------------KSKVTDI--------------- 45

  Fly    66 GPLSQLEPQ--KTLLDMGVPPAA--DRLVVFLLEGLRADTLFSDNCSGAV-YIRDIILRQGLVG- 124
                ..|||  ...::....||.  .|:|:.|::.||.|.:||.|....: |.|.::.:.....
Zfish    46 ----PAEPQTGNNAVNSSRAPALLFKRVVIVLIDALREDFVFSSNGRRFMPYTRHVVEKGSSHSF 106

  Fly   125 ISKTSVPTLTRSAEVALFAGFNPMPSILPTSNFDTIFN--------------------RTLAFDK 169
            |:|...||:|.....||..|  .:|..:     |.:.|                    |.:.:..
Zfish   107 IAKARPPTVTMPRIKALTTG--SIPGFI-----DVVMNLNSPVLLEDNLIWQAKSAGKRIIFYGD 164

  Fly   170 GAFLRF----------------SHLSDLRRRLTKR--ACLEK-------LWYANKLVMLVNLAEV 209
            ..::|.                |..:::...:|:.  :.|::       |.|..    |.::..:
Zfish   165 DTWVRLFPKHFMEQDGTTSFFVSDYTEVDNNVTRHLDSTLKRDDWDILILHYLG----LDHIGHI 225

  Fly   210 GGASPLDIGFQMKLHNTQRNIRDAYELIEATFNDSKT------AYLYTSAHGLTYFGSHGGGSDE 268
            .|.....||.::      ..:.|..:.|.|:....::      ..:....||::..|||||.|::
Zfish   226 SGPHSSLIGPKL------MEMDDIIKKIHASLISKESEGTLPNLLVVCGDHGMSETGSHGGSSEQ 284

  Fly   269 EREAPFLLWGAGVKHVTENITSDFVLNNGVGMQLHK-LDQIQLAPLMSALIGLPPPVNNLA-ILP 331
            |.....:|           |:..|  ...||::... ::|:.|||.::..:|||...|::. ::|
Zfish   285 EINTALVL-----------ISPAF--RRKVGLERPAVVEQVDLAPTLALGLGLPISQNSVGRLIP 336

  Fly   332 QGYMKVSREYARKSVHLNALQL--LTQAKAIIRLHERGVFHK----------------WLPKDKD 378
            ..:.::|.....:.:.:|..||  |.|       ....||||                |:....|
Zfish   337 AVFEELSMREQLRMLQINGHQLSQLLQ-------DSNPVFHKEDGYEQFRVAEKAHGSWMKLYVD 394

  Fly   379 LDLQQIAYYQNQMDHLLDMGWRSKALETSTL-AIKVALKSLKFYHNYYHIPLVVTTVLALLGWQF 442
                     .|:.:.|.:||.:.:......| |:..||......::.|.:.:.:|.:|.:|   |
Zfish   395 ---------GNKSEVLSNMGKKVRKQYLDALKAMSSALSKQMGKYDLYSMIIAMTFILQVL---F 447

  Fly   443 YQL--------------VKLSQNVMA-PHYMRRGYLTWCTIFLASLGLLLGE-------MVFLQW 485
            ..|              |.|:.:::: |.|:       ..:|.::|.:|:..       :..|.|
Zfish   448 LLLLAMPEALSRDAVVDVPLASSLLSLPFYL-------LCLFGSALHVLVCTSAGGPCYLCSLPW 505

  Fly   486 APFMTVICLVVPFGVWCMTLAA--LP-------QNGGW-------------IFEPL--------- 519
            ....:||.|...|....:.:||  ||       ::.||             :|..|
Zfish   506 VLVFSVILLSSAFTCALVGMAARRLPTSNKTPTKSSGWALSELDALLLTGTVFHTLSLGSSSFIE 570

  Fly   520 -KHLRWIVGPAAVMIASIYCNCPLSLAYILCVGFYNRR---------GWLHPSP-----KFLAWL 569
             :|..|      ..:.:..|   |::...:|..::..:         |.|.||.     .|...|
Zfish   571 EEHQTW------YFLLNTLC---LAVFQDVCRRYFREQRQGGEEEDEGPLLPSASDAGLSFSPAL 626

  Fly   570 ALVLLLGGFLWSQKGMQILMTTNYRV-------------------------------VLQAISML 603
            .|.:..|...|...|..:|..|..|:                               ||.|:|:|
Zfish   627 ELGVSAGSEKWLALGTPLLTLTCCRLLRALNQTGVQWAHLPDFGHWLNSGDHKVFLSVLAAVSLL 691

  Fly   604 VVIV---RPCVLNENHKWKVWVINGGILFVAAIGIFLKEMGKPVPLYLFAANWAYLIYAFASVPC 665
            :::|   |.|.|                 |:.|.:.|..:|    :|.:.|....:::.:   |.
Zfish   692 LILVLVQRHCSL-----------------VSKIALTLGLLG----VYSYRAAVGNVLFPW---PH 732

  Fly   666 SSRTTPQSRLELIRFNLLTLHVLLSDSYVSLFAQGLIIEYQMGLEVHEKFKEADEDVKILTS--- 727
            |||...:..:|.....:..|.:|.:.....|.:|.:......|........|....|.:|.:
Zfish   733 SSRQVSKGTVEARFVYVFVLGILFTGVKDLLRSQVMSSAVDSGRLKSRGLWEVYSGVVLLVALLF 797

  Fly   728 SKH----LQMCY-------RFAVSILLYFYASLFGTGHWVGG--FTYLANSARLFLPDSSSGLVP 779
            ..|    |..|.       :|....|.|..|......:|.|.  |.:..||..:...|.|.|.|.
Zfish   798 RAHNLPTLACCLLVQTIMAQFIWKKLHYDAAQTTIMHYWFGQAFFYFQGNSNNIGTVDISVGFVG 862

  Fly   780 LLVLIHLLIPSIVIMASVVALSSFG-------------RQQIRTIFSSL-------MLICNAVVL 824
            |...:.  .|:|::    .|||::.             ..|...:.:.|       .|:.:...:
Zfish   863 LESYVE--APAIIL----TALSTYAGPLLWACHLLCYLSSQTDRVVNGLGHGSYCFALLRSIPAV 921

  Fly   825 FFVVFVP----HNAYWPMAHPSVVHALLAQLTVILILACESIVTIFFRRLNMNR 874
            |:||.|.    |...|.:..|.:::.  |..|:|..:.|     :||..::.:|
Zfish   922 FYVVLVTALRYHLFIWSVFSPKLLYE--AMHTLITTVVC-----LFFTFMDQDR 968

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6790	NP_650087.2	GPI_EPT_1	83..331	CDD:293744	60/304 (20%)
CG6790	NP_650087.2	PigN	418..821	CDD:282796	98/540 (18%)
pigg	XP_005173129.1	Npp1	28..>286	CDD:224441	58/312 (19%)
pigg	XP_005173129.1	GPI_EPT_2	66..335	CDD:293748	58/298 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1524
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810