Protein Alignment Mrp4 and ABCC10

DIOPT Version :9

• Sequence 1: NP_650086.2
• Gene: Mrp4 / 41387
• FlyBaseID: FBgn0263316
• Length: 1316
• Species: Drosophila melanogaster
• Sequence 2: XP_016866934.1
• Gene: ABCC10 / 89845
• HGNCID: 52
• Length: 1558
• Species: Homo sapiens
• Alignment Length: 1381
• Identity: 445/1381 - (32%)
• Similarity: 690/1381 - (49%)
• Gaps: 172/1381 - (12%)

  Fly     7 DELPENPRERSSPLSSLMFCFALPVLFKGRKKTLEQ-KDLYRALKEHKSDSLGDRLCAAWDEQVA 70
            |:.||...:..|.||...:.:..|:|.:|....|.| :|:.|.....:...|.....|.|.|..
Human   259 DQEPEVAEDGESWLSRFSYAWLAPLLARGACGELRQPQDICRLPHRLQPTYLARVFQAHWQEGA- 322

  Fly    71 KNETPRLGRALTKVFGFHLFITGVFLLAQEFLTKVTQPICLIGVMAYFAGNDPDRSKAQLWAAGL 135
                 ||.|||...||......|:..|....| ..:.|:.|..::.:........|...|:|.||
Human   323 -----RLWRALYGAFGRCYLALGLLKLVGTML-GFSGPLLLSLLVGFLEEGQEPLSHGLLYALGL 381

  Fly   136 IAGSVFSVCIGHPYMLGLLHLGMKMRIALSSLIYRKALRLSRTALGDTTVGQVVNLLSNDVGRFD 200
            ..|:|....:.:.|...:..:.::.|.|:.:::|.|||:|..:.   ...|:.:|||..|..|
Human   382 AGGAVLGAVLQNQYGYEVYKVTLQARGAVLNILYCKALQLGPSR---PPTGEALNLLGTDSER-- 441

  Fly   201 LVLIN----VHYLWIAPLELIAVTYLMYLEIGISSMFGVAIMLLFLPFQSYLGKRTSVLRLRTAL 261
              |:|    .|..|..||:|....||:|.::|::.:.|:.:.||.:|....:..|..........
Human   442 --LLNFAGSFHEAWGLPLQLAITLYLLYQQVGVAFVGGLILALLLVPVNKVIATRIMASNQEMLQ 504

  Fly   262 RTDERVRMMNEIISGIQVIKMYAWEKPFGKVVEMTRFNEMLCIKQVNYIRGILISFAMFLSRIFT 326
            ..|.||:::.|::|||:|||...||:..|..||..|..|:..::.:.|:....:.....|..:.:
Human   505 HKDARVKLVTELLSGIRVIKFCGWEQALGARVEACRARELGRLRVIKYLDAACVYLWAALPVVIS 569

  Fly   327 SSSLIAFVLLGNILNAEKAFFVTAYYNILRRSVTMFFPQGISEFAELLVSVRRLEAFMHRPETKV 391
            ....|.:||:|:.|.|.|.|...|...:|...:.. ||..|:...|..||:.|::.|:..|
Human   570 IVIFITYVLMGHQLTATKVFTALALVRMLILPLNN-FPWVINGLLEAKVSLDRIQLFLDLP---- 629

  Fly   392 RDKSKVKNANQKA-ESPN-------------GDSPKGNGIPENLIEFSQFQARWE--SHSLEPTL 440
                   |.|.:| .||:             .|.|   ..|..::|.......|:  ..|||..:
Human   630 -------NHNPQAYYSPDCGRLGAQIKWLLCSDPP---AEPSTVLELHGALFSWDPVGTSLETFI 684

  Fly   441 EDINLQLGRRKLVAVIGPVGAGKSSLIQAILGELPGESGTLRING---SYSYAAQEPWLFTGTVR 502
            ..:.::.|  .||.::|.||.|||||:.||.|||....|.:.:.|   .:..|.||||:...|:|
Human   685 SHLEVKKG--MLVGIVGKVGCGKSSLLAAIAGELHRLRGHVAVRGLSKGFGLATQEPWIQFATIR 747

  Fly   503 QNILFGLDWDKHRYRTVVKKCALERDFELLPFGDKTIVGERGASLSGGQKARISLARAVYRRADI 567
            .|||||..:|...|:.|::.|||..|..:||.||:|.|||:|.:|||||:|||:||||||:..::
Human   748 DNILFGKTFDAQLYKEVLEACALNDDLSILPAGDQTEVGEKGVTLSGGQRARIALARAVYQEKEL 812

  Fly   568 YLLDDPLSAVDTHVGRHLFDQCMRGYLRSELVILVTHQLQFLEQADLIVIMDKGRISAMGTYSSM 632
            |||||||:|||..|..||..:|:.|.|.....:|.||:.::||:||.:::|:.||:...|..|.:
Human   813 YLLDDPLAAVDADVANHLLHRCILGMLSYTTRLLCTHRTEYLERADAVLLMEAGRLIRAGPPSEI 877

  Fly   633 KRSGLDFAQLLTAPNKDAEDLDEIDGAGGDGLDLLNVPSLSRRGSKNSKPSTRNNSFTSLSSMAE 697
                |...|  ..|...||:..|.|.|                    :..|.:|...|. ..:.|
Human   878 ----LPLVQ--AVPKAWAENGQESDSA--------------------TAQSVQNPEKTK-EGLEE 915

  Fly   698 SMAQEASLQMQETRVEGKIGLGLYKEYLTSGSSW--------FMIFFMVFLCLATQILCSAADYF 754
            ..:....|..:|::.||.:.|.:|:.|      |        ..|.|.:.|..||:   :|||::
Human   916 EQSTSGRLLQEESKKEGAVALHVYQAY------WKAVGQGLALAILFSLLLMQATR---NAADWW 971

  Fly   755 LSYWVD----KNVDGQTDINTDPQDM-------YYFAALNVAVVVF------------------- 789
            ||:|:.    :|...:...:|.|..|       ..|:..|:.:.||
Human   972 LSHWISQLKAENSSQEAQPSTSPASMGLFSPQLLLFSPGNLYIPVFPLPKAAPNGSSDIRFYLTV 1036

  Fly   790 -----------TIVRTMLFYKMAMRSSTQLHNAMYQGITRAAMYFFNTNPSGRILNRFSKDLGQL 843
                       |::|.:||....::::..||..:...:..|.:.|||..|:||||||||.|:...
Human  1037 YATIAGVNSLCTLLRAVLFAAGTLQAAATLHRRLLHRVLMAPVTFFNATPTGRILNRFSSDVACA 1101

  Fly   844 DEVLPSVMLDVVQLFLTLLGIIVVICITNPYYLILTLALAIIFYYIREFYLKTSRDVKRLEAVAR 908
            |:.||.::..::.....|||::.|:....|:.|:|...|:|::|:::..|..:||:::||.::..
Human  1102 DDSLPFILNILLANAAGLLGLLAVLGSGLPWLLLLLPPLSIMYYHVQRHYRASSRELRRLGSLTL 1166

  Fly   909 SPIYSHLSATITGLPTIRALGAQKELIAEFDNLQDLHSSGYYTFLATNRAFGYYLDCFCTLY--- 970
            ||:||||:.|:.||..:||.||......|...|.:|:....:...||.:    :||....|.
Human  1167 SPLYSHLADTLAGLSVLRATGATYRFEEENLRLLELNQRCQFATSATMQ----WLDIRLQLMGAA 1227

  Fly   971 IVIIILNYFINPPQ----SPGEVGLAITQAMGMTGMVQWAMRQSAELENTMTAVERVVEYD---E 1028
            :|..|....:...|    :||.|||:::.|:.:||::...:....:.|..:.:|||:.||.   .
Human  1228 VVSAIAGIALVQHQQGLANPGLVGLSLSYALSLTGLLSGLVSSFTQTEAMLVSVERLEEYTCDLP 1292

  Fly  1029 IEPEGEFDSREGKKP---SPSWPEKGEIIAEDLCLRYFPD-PQAKYVLKALNFRIRPCEKVGIVG 1089
            .||:|:        |   ...|..:|.:..:|:.|.|.|. |.|   |..:.|.::|.||:||||
Human  1293 QEPQGQ--------PLQLGTGWLTQGGVEFQDVVLAYRPGLPNA---LDGVTFCVQPGEKLGIVG 1346

  Fly  1090 RTGAGKSSLINALFR-LSYNEGIITIDERDTADMGLFDLRSKISIIPQEPVLFSGSMRYNLDPFE 1153
            |||:|||||:..||| |..:.|.:.:|..||:.:.|..|||:::||||||.||||::|.||||..
Human  1347 RTGSGKSSLLLVLFRLLEPSSGRVLLDGVDTSQLELAQLRSQLAIIPQEPFLFSGTVRENLDPQG 1411

  Fly  1154 EYNDAKLWDALEEVKLKPLISELPNGLQSKISEGGSNFSVGQRQLVCLARAILRENRVLVMDEAT 1218
            .:.|..||.||::..|..:|:.: .||..::.|||.:.|:|||||:|||||:|.:.::|.:||||
Human  1412 LHKDRALWQALKQCHLSEVITSM-GGLDGELGEGGRSLSLGQRQLLCLARALLTDAKILCIDEAT 1475

  Fly  1219 ANVDPQTDALIQATIRSKFRDCTVLTIAHRLNTIMDSDRVLVMDAGHLVEFGSPYELLTSSESKI 1283
            |:||.:||.|:|.||..:|.:.||||||||||||::||||||:.||.:||..||..|.....| :
Human  1476 ASVDQKTDQLLQQTICKRFANKTVLTIAHRLNTILNSDRVLVLQAGRVVELDSPATLRNQPHS-L 1539

  Fly  1284 FHGMVMETGQNTFDSL 1299
            |..::..:.|....||
Human  1540 FQQLLQSSQQGVPASL 1555

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mrp4	NP_650086.2	CFTR_protein	12..1277	CDD:273530	437/1352 (32%)
		ABC_membrane	93..359	CDD:294371	71/269 (26%)
		ABCC_MRP_domain1	422..622	CDD:213217	89/204 (44%)
		ABC_membrane	735..978	CDD:294371	79/286 (28%)
		ABCC_MRP_domain2	1051..1272	CDD:213211	112/222 (50%)
ABCC10	XP_016866934.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151625
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.650