DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mrp4 and YOR1

DIOPT Version :9

Sequence 1:	NP_650086.2	Gene:	Mrp4 / 41387	FlyBaseID:	FBgn0263316	Length:	1316	Species:	Drosophila melanogaster
Sequence 2:	NP_011797.3	Gene:	YOR1 / 853198	SGDID:	S000003513	Length:	1477	Species:	Saccharomyces cerevisiae

Alignment Length:	1460	Identity:	442/1460 - (30%)
Similarity:	698/1460 - (47%)	Gaps:	236/1460 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MQSMKADELPENPRER-------SSPLSSLMFCFALPVLFKGRKKTLEQKDLYRALKEHKSDSLG 58
            :.|.|..|:|:...||       ::.:|::.|.:.||:|..|.|:|::..||::.......::|.
Yeast    90 LHSKKIPEVPQTDDERKIYPLFHTNIISNMFFWWVLPILRVGYKRTIQPNDLFKMDPRMSIETLY 154

  Fly    59 D-------------------RLCAAWDEQVAKN-ETPR--LGRALTKVFGFHLFITGVFLL---- 97
            |                   |...|.:|:|.:| :.|:  :.|||...|....|::.||.:
Yeast   155 DDFEKNMIYYFEKTRKKYRKRHPEATEEEVMENAKLPKHTVLRALLFTFKKQYFMSIVFAILANC 219

  Fly    98 AQEFLTKVTQPIC-LIGVMAYFAGNDPDRSKAQLWAAG-----LIAGSVFSVCIGHPYMLGLLHL 156
            ...|...:|:.:. .:...|.|  :....:|...:|.|     .:.|..|:    |.:....| .
Yeast   220 TSGFNPMITKRLIEFVEEKAIF--HSMHVNKGIGYAIGACLMMFVNGLTFN----HFFHTSQL-T 277

  Fly   157 GMKMRIALSSLIYRKALRLSRTALGDTTVGQVVNLLSNDVGRFDLVLINVHYLWIAPLELIAVTY 221
            |::.:..|:....:|....|..|......|:|.:.::.|:.|.:..|....:|...|..|.....
Yeast   278 GVQAKSILTKAAMKKMFNASNYARHCFPNGKVTSFVTTDLARIEFALSFQPFLAGFPAILAICIV 342

  Fly   222 LMYLEIGISSMFGVAI-----MLLFLPFQSYLGKRTSVLRLRTALRTDERVRMMNEIISGIQVIK 281
            |:.:.:|..::.|:.|     .:....|:..||     .|:...:.||.||.||.|:::.|::||
Yeast   343 LLIVNLGPIALVGIGIFFGGFFISLFAFKLILG-----FRIAANIFTDARVTMMREVLNNIKMIK 402

  Fly   282 MYAWEKPFGKVVEMTRFNEMLCIKQVNYIRGILISFAMFLSRIFTSSSLIAFVLL---------- 336
            .|.||..:.|.::..|..|:..::::...|..||:.||.|..|   :||:.|:.:
Yeast   403 YYTWEDAYEKNIQDIRTKEISKVRKMQLSRNFLIAMAMSLPSI---ASLVTFLAMYKVNKGGRQP 464

  Fly   337 GNILNAEKAFFVTAYYNILRRSVTMFF-PQGISEFAELLVSVRRLEAFMHRPETKVRDKSKVKNA 400
            |||      |...:.:.:|  |:.||| |..|....::::.:.||::.:..||         .:.
Yeast   465 GNI------FASLSLFQVL--SLQMFFLPIAIGTGIDMIIGLGRLQSLLEAPE---------DDP 512

  Fly   401 NQKAE---SPNGDSPKGNGIPENLIEFSQFQARWESHSLEPTLE--------------------- 441
            ||..|   ||..|       |:..::.:.....||.:.|...:|
Yeast   513 NQMIEMKPSPGFD-------PKLALKMTHCSFEWEDYELNDAIEEAKGEAKDEGKKNKKKRKDTW 570

  Fly   442 -----------------------------------DINLQLGRRKLVAVIGPVGAGKSSLIQAIL 471
                                               |:|..:.:.:.:.:.||:|.|||||:.|:.
Yeast   571 GKPSASTNKAKRLDNMLKDRDGPEDLEKTSFRGFKDLNFDIKKGEFIMITGPIGTGKSSLLNAMA 635

  Fly   472 GELPGESGTLRINGSYSYAAQEPWLFTGTVRQNILFGLDWDKHRYRTVVKKCALERDFELLPFGD 536
            |.:....|.:.:||....... ||:...:||.||:||..::|.:|..||:.|:|:.|.::||.||
Yeast   636 GSMRKTDGKVEVNGDLLMCGY-PWIQNASVRDNIIFGSPFNKEKYDEVVRVCSLKADLDILPAGD 699

  Fly   537 KTIVGERGASLSGGQKARISLARAVYRRADIYLLDDPLSAVDTHVGRHLFDQCMRGYLRSELVIL 601
            .|.:||||.:|||||||||:|||:||::.||||.||.|||||:.||:|:.|:|:.|.|.::..||
Yeast   700 MTEIGERGITLSGGQKARINLARSVYKKKDIYLFDDVLSAVDSRVGKHIMDECLTGMLANKTRIL 764

  Fly   602 VTHQLQFLEQADLIVIMDKGRISAMGTYSSMKRSGLDFAQLL--TAPNKDAEDLDEIDGAGGDGL 664
            .||||..:|:|..::::.......:||...:|........||  ::.|.:.||.::.....|:..
Yeast   765 ATHQLSLIERASRVIVLGTDGQVDIGTVDELKARNQTLINLLQFSSQNSEKEDEEQEAVVAGELG 829

  Fly   665 DLLNVPSLSRRGSKNSKPSTRNNSFTSLSSMAESMAQEAS---------LQMQETRVEGKIGLGL 720
            .|              |..:.....|.|...|..|:|.|:         ...:|.|....|.|.:
Yeast   830 QL--------------KYESEVKELTELKKKATEMSQTANSGKIVADGHTSSKEERAVNSISLKI 880

  Fly   721 YKEYLTSG-SSWFMIFFMVFLCLAT-QILCSA-ADYFLSYWVDKNVDGQTDINTDPQ------DM 776
            |:||:.:. ..|..|...::..|.. ...||. :..:||||.:....     |..|.      ..
Yeast   881 YREYIKAAVGKWGFIALPLYAILVVGTTFCSLFSSVWLSYWTENKFK-----NRPPSFYMGLYSF 940

  Fly   777 YYFAALNVAVVVFTIVRTMLFYKMAMRSSTQLHNAMYQGITRAAMYFFNTNPSGRILNRFSKDLG 841
            :.|||.......|||:     ..|.:.:|..|:....:.|....|.:.:|.|.|||||||:||..
Yeast   941 FVFAAFIFMNGQFTIL-----CAMGIMASKWLNLRAVKRILHTPMSYIDTTPLGRILNRFTKDTD 1000

  Fly   842 QLDEVLPSVMLDVVQLFLTLLGIIVVICITNPYYLILTLALAIIFYYIREFYLKTSRDVKRLEAV 906
            .||..|...:..:...|..::|:.|:..:..|::.|....|.:||..|.:.|..:.|::||||||
Yeast  1001 SLDNELTESLRLMTSQFANIVGVCVMCIVYLPWFAIAIPFLLVIFVLIADHYQSSGREIKRLEAV 1065

  Fly   907 ARSPIYSHLSATITGLPTIRALGAQKELIAEFDNLQDLHSSGYYTFLATNRAFGYYLDCFCTLYI 971
            .||.:|::|:..:.|:.||:|..:|:..:|:.|.|.:..:...|..:...|..|.:||.....:.
Yeast  1066 QRSFVYNNLNEVLGGMDTIKAYRSQERFLAKSDFLINKMNEAGYLVVVLQRWVGIFLDMVAIAFA 1130

  Fly   972 VIIILNYFINP-PQSPGEVGLAITQAMGMTGMVQWAMRQSAELENTMTAVERVVEY-DEIEPEGE 1034
            :||.|...... |.|...||:.:|..:.:.|::...:|...:.||.|.:.||:|.| .|:..|..
Yeast  1131 LIITLLCVTRAFPISAASVGVLLTYVLQLPGLLNTILRAMTQTENDMNSAERLVTYATELPLEAS 1195

  Fly  1035 FDSREGKKPSPSWPEKGEIIAEDLCLRYFPDPQAKYVLKALNFRIRPCEKVGIVGRTGAGKSSLI 1099
            :...| ..|..|||..||||.|::...|  .|....|||.||..|:..||:||.||||||||:::
Yeast  1196 YRKPE-MTPPESWPSMGEIIFENVDFAY--RPGLPIVLKNLNLNIKSGEKIGICGRTGAGKSTIM 1257

  Fly  1100 NALFRLSYNE---GIITIDERDTADMGLFDLRSKISIIPQEPVLFSGSMRYNLDPFEEYNDAKLW 1161
            :||:||  ||   |.|.||..|.:.:||||||.|::||||:||||.|::|.|||||.|..|.:||
Yeast  1258 SALYRL--NELTAGKILIDNVDISQLGLFDLRRKLAIIPQDPVLFRGTIRKNLDPFNERTDDELW 1320

  Fly  1162 DA-----------LEEVKL-KPLISELPNGLQSK---------ISEGGSNFSVGQRQLVCLARAI 1205
            ||           |.|||| ||  .|  ||...|         :.|.|||||:|:|||:.|.||:
Yeast  1321 DALVRGGAIAKDDLPEVKLQKP--DE--NGTHGKMHKFHLDQAVEEEGSNFSLGERQLLALTRAL 1381

  Fly  1206 LRENRVLVMDEATANVDPQTDALIQATIRSKFRDCTVLTIAHRLNTIMDSDRVLVMDAGHLVEFG 1270
            :|::::|::||||::||.:||..||..|..:|.|||:|.|||||.||::.||:||::.|.:.||.
Yeast  1382 VRQSKILILDEATSSVDYETDGKIQTRIVEEFGDCTILCIAHRLKTIVNYDRILVLEKGEVAEFD 1446

  Fly  1271 SPYELLTSSESKIFHGMVMETG--QNTFDS 1298
            :|:.|. |.|..||..|...:|  :|.|::
Yeast  1447 TPWTLF-SQEDSIFRSMCSRSGIVENDFEN 1475

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mrp4	NP_650086.2	CFTR_protein	12..1277	CDD:273530	430/1424 (30%)
		ABC_membrane	93..359	CDD:294371	65/290 (22%)
		ABCC_MRP_domain1	422..622	CDD:213217	83/255 (33%)
		ABC_membrane	735..978	CDD:294371	71/250 (28%)
		ABCC_MRP_domain2	1051..1272	CDD:213211	120/244 (49%)
YOR1	NP_011797.3	MRP_assoc_pro	92..1468	CDD:188098	439/1449 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.710