Protein Alignment Mrp4 and BPT1

DIOPT Version :9

• Sequence 1: NP_650086.2
• Gene: Mrp4 / 41387
• FlyBaseID: FBgn0263316
• Length: 1316
• Species: Drosophila melanogaster
• Sequence 2: NP_013086.1
• Gene: BPT1 / 850645
• SGDID: S000003938
• Length: 1559
• Species: Saccharomyces cerevisiae
• Alignment Length: 1366
• Identity: 442/1366 - (32%)
• Similarity: 718/1366 - (52%)
• Gaps: 198/1366 - (14%)

  Fly    56 SLGDRLCAAWDEQVAKNETPRLGRALTKVFGFHLFITGVFLLAQEFLTKVTQPICLIGVMAYFAG 120
            |:.....|.|:.:...|.. .|.||:.|.||..:.:..::....:.|: |.||..|   ..:..|
Yeast   260 SISKEFKANWELEKWLNRN-SLWRAIWKSFGRTISVAMLYETTSDLLS-VVQPQFL---RIFIDG 319

  Fly   121 NDPDRS------KAQLWAAGLIAGSVFSVCIGHPYMLGLLHLGMKMRIALSSLIYRKALRLSRTA 179
            .:|:.|      .....|..|...||.||.:.:.:.:|:...|:.:|.:|:||:|:|:|||:...
Yeast   320 LNPETSSKYPPLNGVFIALTLFVISVVSVFLTNQFYIGIFEAGLGIRGSLASLVYQKSLRLTLAE 384

  Fly   180 LGDTTVGQVVNLLSNDVGRFDLVLINVHYLWIAPLELIAVTYLMYLEIGISSMFGVAIMLLFLPF 244
            ..:.:.|.::||:|.||.|......|...:..||:::|.|...:|..:|.:.:.|:..|.:.:|.
Yeast   385 RNEKSTGDILNLMSVDVLRIQRFFENAQTIIGAPIQIIVVLTSLYWLLGKAVIGGLVTMAIMMPI 449

  Fly   245 QSYLGKRTSVLRLRTALRTDERVRMMNEIISGIQVIKMYAWEKPFGKVVEMTRFN------EMLC 303
            .::|.::...|........|.|::.:.|:::.|:.||:||||:|.     |.|.|      |:..
Yeast   450 NAFLSRKVKKLSKTQMKYKDMRIKTITELLNAIKSIKLYAWEEPM-----MARLNHVRNDMELKN 509

  Fly   304 IKQVNYIRGILI-------------SFAMFLSRIFTSSSL---IAF--VLLGNILNAEKAFFVTA 350
            .:::..:..::.             :|.:|  .:|:.|.|   |.|  :.|.||||       :|
Yeast   510 FRKIGIVSNLIYFAWNCVPLMVTCSTFGLF--SLFSDSPLSPAIVFPSLSLFNILN-------SA 565

  Fly   351 YYNILRRSVTMFFPQGISEFAELLVSVRRLEAFMHRPETKVRDKSKVKNANQKAESPNGDSPKGN 415
            .|::         |..|:...|..||:.||::|:...|.   |.|.::..:..|:.        .
Yeast   566 IYSV---------PSMINTIIETSVSMERLKSFLLSDEI---DDSFIERIDPSADE--------R 610

  Fly   416 GIPENLIEFSQFQARWESH---------------------SLEPTLEDI-NLQLGRRKLVAVIGP 458
            .:|  .||.:.....|:|.                     |.:..|::| :.:..|..||.|:|.
Yeast   611 ALP--AIEMNNITFLWKSKEVLTSSQSGDNLRTDEESIIGSSQIALKNIDHFEAKRGDLVCVVGR 673

  Fly   459 VGAGKSSLIQAILGELPGESGT---------LRINGSYSYAAQEPWLFTGTVRQNILFGLDWDKH 514
            ||||||:.::||||:||..||:         :| :.|.:|.:||.|:...:||:|||||..:|:.
Yeast   674 VGAGKSTFLKAILGQLPCMSGSRDSIPPKLIIR-SSSVAYCSQESWIMNASVRENILFGHKFDQD 737

  Fly   515 RYRTVVKKCALERDFELLPFGDKTIVGERGASLSGGQKARISLARAVYRRADIYLLDDPLSAVDT 579
            .|...:|.|.|..|.::||.||:|:|||:|.|||||||||:|||||||.|||||||||.|||||.
Yeast   738 YYDLTIKACQLLPDLKILPDGDETLVGEKGISLSGGQKARLSLARAVYSRADIYLLDDILSAVDA 802

  Fly   580 HVGRHLFDQCMRG---YLRSELVILVTHQLQFLEQADLIVIMDKGRISAMGTY----------SS 631
            .|.:::.:..:.|   .|:::.:||.|:.:..|:.:.:|..::.|.|...|.|          |.
Yeast   803 EVSKNIIEYVLIGKTALLKNKTIILTTNTVSILKHSQMIYALENGEIVEQGNYEDVMNRKNNTSK 867

  Fly   632 MK----------------------RSGLDFAQLLTAPNKDAEDLDEIDGAGGDGLDLLNVPSLSR 674
            :|                      ||..:..:.|.....::|..||:  .....|:|  :.:.||
Yeast   868 LKKLLEEFDSPIDNGNESDVQTEHRSESEVDEPLQLKVTESETEDEV--VTESELEL--IKANSR 928

  Fly   675 RGSKNSKPSTRNNSF--TSLSSMAESMAQEASLQMQETRVEGKIGLGLYKEYLTSGSSWFMIFFM 737
            |.   |..:.|...|  ..|.|:.:: ||:|    ::|.| |::...:|..|:.:.....::.|.
Yeast   929 RA---SLATLRPRPFVGAQLDSVKKT-AQKA----EKTEV-GRVKTKIYLAYIKACGVLGVVLFF 984

  Fly   738 VFLCLATQILCSAADYFLSYWVDKNVDGQTDINTDPQDMYYF----AALNVAVVVFTIVRT--ML 796
            :|:.| |::...|.:::|.||.:.|     :.|...:.::.|    :.:.||...|..:|:  ||
Yeast   985 LFMIL-TRVFDLAENFWLKYWSESN-----EKNGSNERVWMFVGVYSLIGVASAAFNNLRSIMML 1043

  Fly   797 FYKMAMRSSTQLHNAMYQGITRAAMYFFNTNPSGRILNRFSKDLGQLDEVLPSVMLDVVQLFLTL 861
            .| .::|.|.:||.:|.:.:.|:.|.||.|.|.|||:||||.|:..:|..|..:.....:..||.
Yeast  1044 LY-CSIRGSKKLHESMAKSVIRSPMTFFETTPVGRIINRFSSDMDAVDSNLQYIFSFFFKSILTY 1107

  Fly   862 LGIIVVICITNPYYLILTLALAIIFYYIREFYLKTSRDVKRLEAVARSPIYSHLSATITGLPTIR 926
            |..::::....|::|:..:.|.:|:.|.:.||:..||::|||.:::.|||.|.:|.::.|...|.
Yeast  1108 LVTVILVGYNMPWFLVFNMFLVVIYIYYQTFYIVLSRELKRLISISYSPIMSLMSESLNGYSIID 1172

  Fly   927 ALG-AQKELIAEFDNLQDLHSSGYYTFLATNRAFGYYLDCF-CTLYIVIIILNY-FINPPQ--SP 986
            |.. .::.:...::.:| .:....:.|.:|||.....|... .|:.:...||.. .:|..:  |.
Yeast  1173 AYDHFERFIYLNYEKIQ-YNVDFVFNFRSTNRWLSVRLQTIGATIVLATAILALATMNTKRQLSS 1236

  Fly   987 GEVGLAITQAMGMTGMVQWAMRQSAELENTMTAVERVVEYDEIEPEGEFDSREGKKPSPSWPEKG 1051
            |.|||.::.::.:||.:.|.:|.:..:|..:.:|||:|||.|:.||.:..:.| |:|..:||.||
Yeast  1237 GMVGLLMSYSLEVTGSLTWIVRTTVTIETNIVSVERIVEYCELPPEAQSINPE-KRPDENWPSKG 1300

  Fly  1052 EIIAEDLCLRYFP--DPQAKYVLKALNFRIRPCEKVGIVGRTGAGKSSLINALFR-LSYNEGIIT 1113
            .|..::...:|..  ||    ||..:|.:|.||||||||||||||||:|..|||| |...||.|.
Yeast  1301 GIEFKNYSTKYRENLDP----VLNNINVKIEPCEKVGIVGRTGAGKSTLSLALFRILEPTEGKII 1361

  Fly  1114 IDERDTADMGLFDLRSKISIIPQEPVLFSGSMRYNLDPFEEYNDAKLWDALEEVKLKPLISEL-- 1176
            ||..|.:|:|||||||.::||||:...|.|:::.|||||..|::.:|..|:|:..|||.:.::
Yeast  1362 IDGIDISDIGLFDLRSHLAIIPQDAQAFEGTVKTNLDPFNRYSEDELKRAVEQAHLKPHLEKMLH 1426

  Fly  1177 --PNG-------------LQSKISEGGSNFSVGQRQLVCLARAILRENRVLVMDEATANVDPQTD 1226
              |.|             |..||:|.|||.|||||||:|||||:|..:::||:|||||:||.:||
Yeast  1427 SKPRGDDSNEEDGNVNDILDVKINENGSNLSVGQRQLLCLARALLNRSKILVLDEATASVDMETD 1491

  Fly  1227 ALIQATIRSKFRDCTVLTIAHRLNTIMDSDRVLVMDAGHLVEFGSPYELLTSSESKIFHGMVMET 1291
            .:||.|||.:|:|.|:||||||::|::|||:::|:|.|.:.||.||.:|| |.::.||:.:..:.
Yeast  1492 KIIQDTIRREFKDRTILTIAHRIDTVLDSDKIIVLDQGSVREFDSPSKLL-SDKTSIFYSLCEKG 1555

  Fly  1292 G 1292
            |
Yeast  1556 G 1556

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mrp4	NP_650086.2	CFTR_protein	12..1277	CDD:273530	437/1349 (32%)
		ABC_membrane	93..359	CDD:294371	73/295 (25%)
		ABCC_MRP_domain1	422..622	CDD:213217	92/233 (39%)
		ABC_membrane	735..978	CDD:294371	71/250 (28%)
		ABCC_MRP_domain2	1051..1272	CDD:213211	119/240 (50%)
BPT1	NP_013086.1	MRP_assoc_pro	222..1556	CDD:188098	441/1364 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344628
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.650