DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mrp4 and ABCC15

DIOPT Version :9

Sequence 1:	NP_650086.2	Gene:	Mrp4 / 41387	FlyBaseID:	FBgn0263316	Length:	1316	Species:	Drosophila melanogaster
Sequence 2:	NP_191656.2	Gene:	ABCC15 / 825269	AraportID:	AT3G60970	Length:	1053	Species:	Arabidopsis thaliana

Alignment Length:	1126	Identity:	359/1126 - (31%)
Similarity:	586/1126 - (52%)	Gaps:	116/1126 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   192 LSNDVGRFDLVLINVHYLWIAPLELIAVTYLMYLEIGISSMFGVAIMLLFLPFQSYLGK-----R 251
            :|.||.|....:..|:.:|:.|:::.:..|::...:|:.::..:...|:.:.....|.:     :
plant     1 MSVDVQRITDFIWYVNSIWMLPIQIFSAIYILQKHLGLGALAALVTTLMVMACNYPLTRLQRNYQ 65

  Fly   252 TSVLRLRTALRTDERVRMMNEIISGIQVIKMYAWEKPFGKVVEMTRFNEMLCI-KQVNYIRGILI 315
            :.::..:     |:|::..:||:..::::|:.||:..|...|:..|..|..|: |.:.     |.
plant    66 SDIMNAK-----DDRMKATSEILKNMKILKLQAWDNQFLNKVKTLRKKEYDCLWKSLR-----LQ 120

  Fly   316 SFAMFLSRIFTSSSLIAFV------LLGNILNAEKAFFVTAYYNILRRSVTMFFPQGISEFAELL 374
            .|..|:  ::.:.|||:.|      |:|..|.|.......|.:.:| :|.....|..:|...:..
plant   121 DFTTFI--LWGAPSLISVVTFVTCMLMGVKLTAGAVLSALATFQML-QSPIFGLPDLLSALVQSK 182

  Fly   375 VSVRRLEAFMHRPETKVRDKSKVKNANQKAESPNGDSPKGNGIPENLIEFSQFQARWESHSLEPT 439
            ||..|:.:::.:.||:   |..|:..:             |...|..:|.......||..|..||
plant   183 VSADRIASYLQQSETQ---KDAVEYCS-------------NDHTEFSVEIENGAFSWEPESSRPT 231

  Fly   440 LEDINLQLGRRKLVAVIGPVGAGKSSLIQAILGELPGESGTLRINGSYSYAAQEPWLFTGTVRQN 504
            |:||.|::.....||:.|.||:|||||..:||||:....||:|::|..:|..|.||:.:||:|.|
plant   232 LDDIELKVKSGMKVAICGAVGSGKSSLPSSILGEIQKLKGTVRVSGKQAYVPQSPWILSGTIRDN 296

  Fly   505 ILFGLDWDKHRYRTVVKKCALERDFELLPFGDKTIVGERGASLSGGQKARISLARAVYRRADIYL 569
            ||||..::..:|...||.|||.:||||...||.|.:||||.::|||||.||.:|||||:.|||||
plant   297 ILFGSIYESEKYERTVKACALIKDFELFSNGDLTEIGERGINMSGGQKQRIQIARAVYQNADIYL 361

  Fly   570 LDDPLSAVDTHVGRHLFDQCMRGYLRSELVILVTHQLQFLEQADLIVIMDKGRISAMGTYSSMKR 634
            ||||.||||.|.||.||:.|:.|.|:.:.|:.||||::||..||||::|..||:...|.:..:.:
plant   362 LDDPFSAVDAHTGRELFEDCLMGILKDKTVLYVTHQVEFLPAADLILVMQNGRVMQAGKFEELLK 426

  Fly   635 SGLDFAQLLTAPNKDAEDLDEIDGAGGDGLDLLNVPSLSRRGSKNSKPSTRNNSFTSLSSMAESM 699
            ..:.|           |.|.:.|                         |..|.|       .|:.
plant   427 QNIGF-----------EVLTQCD-------------------------SEHNIS-------TENK 448

  Fly   700 AQEASLQMQETRVEGKIGLGLYKEYLTSGSSWFMIFFMVFLCLATQILCSAADYFLSYWVDKNVD 764
            .:||.|...|...:|.||..:|..|||:.....::.|::......|:|..|::|::::......:
plant   449 KKEAKLVQDEETEKGVIGKEVYLTYLTTVKGGLLVPFIILAQSCFQMLQIASNYWMAWTAPPTAE 513

  Fly   765 GQTDINTDPQDMYYFAALNVAVVVFTIVRTMLFYKMAMRSSTQLHNAMYQGITRAAMYFFNTNPS 829
            ....:... :.:..:|.|.....:..:.||:|.....:.::....:.|...|.||.|.:|::.|:
plant   514 SIPKLGMG-RILLVYALLAAGSSLCVLARTILVAIGGLSTAETFFSRMLCSIFRAPMSYFDSTPT 577

  Fly   830 GRILNRFSKDLGQLDEVLPSVML-----DVVQLFLTLLGIIVV---ICITNPYYLILTLALAIIF 886
            ||||||.|.|...||..: :|.|     .::|:..|:..:..|   :|:     :.:.:|:|.:|
plant   578 GRILNRASTDQSVLDLEM-AVKLGWCAFSIIQIVGTIFVMSQVAWQVCV-----IFIPVAVACVF 636

  Fly   887 YYIREFYLKTSRDVKRLEAVARSPIYSHLSATITGLPTIRALGAQKELIAEFDNLQDLHSSGYYT 951
            |  :.:|..|.|::.|:..|.|:||..|.:.::.|..||||...:...|:....|.|.||..::.
plant   637 Y--QRYYTPTERELSRMSGVERAPILHHFAESLAGATTIRAFDQRDRFISSNLVLIDSHSRPWFH 699

  Fly   952 FLATNRAFGYYLDCFCTLYIVIIILNYFINPPQ---SPGEVGLAITQAMGMTGMVQWAMRQSAEL 1013
            ..:......:.|: ..:.::....|...:..|:   :|...||.:|..:.:..:....:......
plant   700 VASAMEWLSFRLN-LLSHFVFAFSLVLLVTLPEGVINPSIAGLGVTYGLSLNVLQATVIWNICNA 763

  Fly  1014 ENTMTAVERVVEYDEIEPEGEFDSREGKKPSPSWPEKGEIIAEDLCLRY---FPDPQAKYVLKAL 1075
            ||.|.:|||::::.:|..|... ..:.::|..:||..|.|:..||.:||   ||     .|||.:
plant   764 ENKMISVERILQHSKIPSEAPL-VIDDQRPLDNWPNVGSIVFRDLQVRYAEHFP-----AVLKNI 822

  Fly  1076 NFRIRPCEKVGIVGRTGAGKSSLINALFRL-SYNEGIITIDERDTADMGLFDLRSKISIIPQEPV 1139
            .......:|:|:|||||:|||:||.||||: ..:.|.|.||..|...:||.||||::.||||:..
plant   823 TCAFPGGKKIGVVGRTGSGKSTLIQALFRIVEPSHGTIVIDNVDITKIGLHDLRSRLGIIPQDNA 887

  Fly  1140 LFSGSMRYNLDPFEEYNDAKLWDALEEVKLKPLISELPNGLQSKISEGGSNFSVGQRQLVCLARA 1204
            ||.|::|.||||..:|.|.::|:||::.:|..:|......|.:.:.|.|.|:||||||||||.|.
plant   888 LFDGTIRLNLDPLAQYTDREIWEALDKCQLGDVIRAKDEKLDATVVENGENWSVGQRQLVCLGRV 952

  Fly  1205 ILRENRVLVMDEATANVDPQTDALIQATIRSKFRDCTVLTIAHRLNTIMDSDRVLVMDAGHLVEF 1269
            :|:::.:||:|||||:||..||.:||..|..:|:|.||:|||||::|:::||.|||:..|.:.||
plant   953 LLKKSNILVLDEATASVDSATDGVIQKIINQEFKDRTVVTIAHRIHTVIESDLVLVLSDGRIAEF 1017

  Fly  1270 GSPYELLTSSESKIFHGMVME 1290
            .||.:|| ..|...|..::.|
plant  1018 DSPAKLL-QREDSFFSKLIKE 1037

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mrp4	NP_650086.2	CFTR_protein	12..1277	CDD:273530	355/1111 (32%)
		ABC_membrane	93..359	CDD:294371	37/178 (21%)
		ABCC_MRP_domain1	422..622	CDD:213217	102/199 (51%)
		ABC_membrane	735..978	CDD:294371	58/250 (23%)
		ABCC_MRP_domain2	1051..1272	CDD:213211	105/224 (47%)
ABCC15	NP_191656.2	ABC_membrane	<1..170	CDD:294371	38/181 (21%)
		EcfA2	214..428	CDD:224047	105/213 (49%)
		ABCC_MRP_domain1	214..414	CDD:213217	102/199 (51%)
		MdlB	481..1037	CDD:224055	185/572 (32%)
		ABC_membrane	520..756	CDD:294371	58/245 (24%)
		ABCC_MRP_domain2	800..1020	CDD:213211	105/224 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	99	1.000	Domainoid score	I2369
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.720