DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mrp4 and ABCC10

DIOPT Version :9

Sequence 1:	NP_650086.2	Gene:	Mrp4 / 41387	FlyBaseID:	FBgn0263316	Length:	1316	Species:	Drosophila melanogaster
Sequence 2:	NP_191473.2	Gene:	ABCC10 / 825083	AraportID:	AT3G59140	Length:	1453	Species:	Arabidopsis thaliana

Alignment Length:	1305	Identity:	402/1305 - (30%)
Similarity:	681/1305 - (52%)	Gaps:	93/1305 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 SSLMFCFALPVLFKGRKKTLEQKDLYRALKEHKSDSLGDRLCAAWDEQVAKNETPRLGRA----- 80
            |:|.|.:...::.:|..|.||::|:....||.::::     |.:..|:....:..|||.:
plant   214 STLSFWWLNSLIKRGNVKDLEEEDIPELRKEERAET-----CYSLFEENLIEQKRRLGSSCQPSI 273

  Fly    81 --LTKVFGFHLFITGVFLLAQEFLTKVTQPICLIGVMAYFAGNDPDRSKAQLWAAGLIAGSVFSV 143
              :|.:..:...:|..|....:.:.....|:.|...:....||...|.:..:.|..|....:...
plant   274 LKVTVLCVWRELLTSGFFAFMKIVAVSAGPLLLNAFILVAEGNASFRYEGLVLAVLLFFSKMIES 338

  Fly   144 CIGHPYMLGLLHLGMKMRIALSSLIYRKALRLSRTALGDTTVGQVVNLLSNDVGRFDLVLINVHY 208
            .....:......:|:::|..|::.|.:|.|||:.::....:..:::|..:.|..|........|.
plant   339 LSQRQWYFRCRIVGLRVRSLLTAAINKKQLRLNNSSRLIHSGSEIMNYATVDAYRIGEFPYWFHQ 403

  Fly   209 LWIAPLELIAVTYLMYLEIGISSMFGVAIMLLFLPFQSYLGKRTSVLRLRTALRTDERVRMMNEI 273
            ||....:|:....:::..:|:::...:|:::|.:...:.:.|..:..:.......|||::..||.
plant   404 LWTTSFQLLIALGILFHSVGVATFSALAVIILTVLCNAPIAKLQNKFQSELMTSQDERLKACNES 468

  Fly   274 ISGIQVIKMYAWEKPFGKVVEMTRFNEMLCIKQVNYIRGILISFAMFLSRIFTSSSLIAFVLLGN 338
            :..::|:|:||||..|.||:|..|..|:..:|.|. :|....:...:.|.:|.|::..|.....:
plant   469 LVNMKVLKLYAWESHFKKVIEKLRNIELKSLKAVQ-MRKAYNAVLFWSSPVFVSAATFATCYFLD 532

  Fly   339 I-LNAEKAFFVTAYYNILRRSVTMFFPQGISEFAELLVSVRRLEAFMHRPETKVRDKSKVKNANQ 402
            | |.|...|...|...:::..|.| .|..|....:..|:..|:..|:..||.:..::.:    .|
plant   533 IPLRASNVFTFVATLRLVQDPVRM-IPDVIGVTIQAKVAFSRIATFLEAPELQGGERRR----KQ 592

  Fly   403 KAESPNGDSPKGNGIPENLIEFSQFQARWESH-SLEPTLEDINLQLGRRKLVAVIGPVGAGKSSL 466
            ::|        ||   :|.|........||.. |.:|.|.:::|::...:.|||.|.||:|||:|
plant   593 RSE--------GN---QNAIIIKSASFSWEEKGSTKPNLRNVSLEVKFGEKVAVCGEVGSGKSTL 646

  Fly   467 IQAILGELPGESGTLRINGSYSYAAQEPWLFTGTVRQNILFGLDWDKHRYRTVVKKCALERDFEL 531
            :.|||||.|..|||:...|:.:|.:|..|:.|||:|.|||||...|:||||..::|.:|::|.||
plant   647 LAAILGETPCVSGTIDFYGTIAYVSQTAWIQTGTIRDNILFGGVMDEHRYRETIQKSSLDKDLEL 711

  Fly   532 LPFGDKTIVGERGASLSGGQKARISLARAVYRRADIYLLDDPLSAVDTHVGRHLFDQCMRGYLRS 596
            ||.||:|.:||||.:||||||.||.||||:|:.|||||||||.||||.|....||.:.:...|..
plant   712 LPDGDQTEIGERGVNLSGGQKQRIQLARALYQDADIYLLDDPFSAVDAHTASSLFQEYVMDALAG 776

  Fly   597 ELVILVTHQLQFLEQADLIVIMDKGRISAMGTYSSMKRSGLDFAQLLTAPNKDAEDLDEIDGAGG 661
            :.|:|||||:.||...|.:::|..|.|:...||..:.....||..|:.|..         :.||.
plant   777 KAVLLVTHQVDFLPAFDSVLLMSDGEITEADTYQELLARSRDFQDLVNAHR---------ETAGS 832

  Fly   662 DGLDLLNVPSLSRRGSKNSKPSTRNNSFTSLSSMAESMAQEASLQMQETRVEGKIGLGLYKEYLT 726
            :.:..:..|         :||....|...|..|   .:.:.:.|..||.|.:|..||..|.:|:.
plant   833 ERVVAVENP---------TKPVKEINRVISSQS---KVLKPSRLIKQEEREKGDTGLRPYIQYMN 885

  Fly   727 SGSSWFMIFFMVFLCLATQILCSAADYFLSYWVDKNVDGQTDINTDPQD-----MYYFAALNVAV 786
            ....:  |||  |:....|:..:......:.|:..|||       :||.     :..:..:.:..
plant   886 QNKGY--IFF--FIASLAQVTFAVGQILQNSWMAANVD-------NPQVSTLKLILVYLLIGLCS 939

  Fly   787 VVFTIVRTMLFYKMAMRSSTQLHNAMYQGITRAAMYFFNTNPSGRILNRFSKDLGQLDEVLPSVM 851
            |:..:||::....|.|:||..|.:.:...:.||.|.|:::.|.||||:|.|.||..:|..:|..:
plant   940 VLCLMVRSVCVVIMCMKSSASLFSQLLNSLFRAPMSFYDSTPLGRILSRVSSDLSIVDLDVPFGL 1004

  Fly   852 LDVVQLFLTLLGIIVVICITNPYYLILTLALAIIFYYIREFYLKTSRDVKRLEAVARSPIYSHLS 916
            :.||...:.....:.|:.|.....|.:::.:..:.:.::::|.:|::::.|:....||.:.:||:
plant  1005 IFVVASSVNTGCSLGVLAIVTWQVLFVSVPMVYLAFRLQKYYFQTAKELMRINGTTRSYVANHLA 1069

  Fly   917 ATITGLPTIRALGAQKELIAEFDNLQDLHSSGYYTFLATNRAFGYYLD----------CFCTLYI 971
            .::.|..||||...::....:...|.|.::|.::...|.|......|:          .||   :
plant  1070 ESVAGAITIRAFDEEERFFKKSLTLIDTNASPFFHSFAANEWLIQRLETVSAIVLASTAFC---M 1131

  Fly   972 VIIILNYFINPPQSPGEVGLAITQAMGMTGMVQWAMRQSAELENTMTAVERVVEYDEIEPEGEFD 1036
            :::....|     |.|.:|:|::..:.:...:.::::....|.|.:.:|||:.:|..:.||.. :
plant  1132 ILLPTGTF-----SSGFIGMALSYGLSLNMGLVYSVQNQCYLANWIISVERLNQYTHLTPEAP-E 1190

  Fly  1037 SREGKKPSPSWPEKGEIIAEDLCLRYFPDPQAKYVLKALNFRIRPCEKVGIVGRTGAGKSSLINA 1101
            ..|..:|..:||..|.:...||.:||  ..::..|||.::.......|:|||||||:||::||:|
plant  1191 VIEETRPPVNWPVTGRVEISDLQIRY--RRESPLVLKGISCTFEGGHKIGIVGRTGSGKTTLISA 1253

  Fly  1102 LFRL-SYNEGIITIDERDTADMGLFDLRSKISIIPQEPVLFSGSMRYNLDPFEEYNDAKLWDALE 1165
            |||| ....|.|.:|..|.:.:|:.||||:..||||:|.||:|::|:||||..:::||::|:.|.
plant  1254 LFRLVEPVGGKIVVDGVDISKIGVHDLRSRFGIIPQDPTLFNGTVRFNLDPLCQHSDAEIWEVLG 1318

  Fly  1166 EVKLKPLISELPNGLQSKISEGGSNFSVGQRQLVCLARAILRENRVLVMDEATANVDPQTDALIQ 1230
            :.:||.::.|..|||.|.:.|.|||:|:|||||.||.||:||.:||||:|||||::|..||.::|
plant  1319 KCQLKEVVQEKENGLDSLVVEDGSNWSMGQRQLFCLGRAVLRRSRVLVLDEATASIDNATDLILQ 1383

  Fly  1231 ATIRSKFRDCTVLTIAHRLNTIMDSDRVLVMDAGHLVEFGSPYELLTSSESKIFHGMVME--TGQ 1293
            .|||.:|.||||:|:|||:.|:||...||.:..|.:||:..|.:|: ..|:.:|..:|.|  :..
plant  1384 KTIRREFADCTVITVAHRIPTVMDCTMVLSISDGRIVEYDEPMKLM-KDENSLFGKLVKEYWSHY 1447

  Fly  1294 NTFDS 1298
            |:.||
plant  1448 NSADS 1452

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mrp4	NP_650086.2	CFTR_protein	12..1277	CDD:273530	395/1280 (31%)
		ABC_membrane	93..359	CDD:294371	56/266 (21%)
		ABCC_MRP_domain1	422..622	CDD:213217	98/200 (49%)
		ABC_membrane	735..978	CDD:294371	58/257 (23%)
		ABCC_MRP_domain2	1051..1272	CDD:213211	107/221 (48%)
ABCC10	NP_191473.2	MRP_assoc_pro	194..1437	CDD:188098	396/1288 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	64	1.000	Domainoid score	I3649
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.720