DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mrp4 and ABCC3

DIOPT Version :9

Sequence 1:	NP_650086.2	Gene:	Mrp4 / 41387	FlyBaseID:	FBgn0263316	Length:	1316	Species:	Drosophila melanogaster
Sequence 2:	NP_187915.1	Gene:	ABCC3 / 820496	AraportID:	AT3G13080	Length:	1514	Species:	Arabidopsis thaliana

Alignment Length:	1341	Identity:	427/1341 - (31%)
Similarity:	695/1341 - (51%)	Gaps:	127/1341 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 PRERSSPLSSLMFCFALPVLFKGRKKTLEQKDLYRALKEHKSDSL----------------GDRL 61
            |..|:..||.|.|.:..|::..|.||||:.:|:.:.   |.:||:                |:|
plant   245 PYSRAGILSLLTFSWMSPLIDIGNKKTLDLEDVPQL---HDTDSVVGLAPKFRSMLESPDGGER- 305

  Fly    62 CAAWDEQVAKNETPRLGRALTKVFGFHLFITGVFLLAQEFLTKVTQ---PICLIGVMAYFAGNDP 123
                    :...|.:|.:||.....:.:.:|..|    .|:..|..   |..:...:.|..|...
plant   306 --------SGVTTFKLIKALYFTAQWEILVTAFF----AFIYTVASYVGPALIDTFVQYLNGRRQ 358

  Fly   124 DRSKAQLWAAGLIAGSVFSVCIGHPYMLGLLHLGMKMRIALSSLIYRKALRLSRTALGDTTVGQV 188
            ...:..:......|..:........:...|..:|::||.||.::||.|.|.||..:....|.|::
plant   359 YNHEGYVLVITFFAAKIVECLSQRHWFFRLQKVGIRMRSALVAMIYEKGLTLSCQSKQGRTSGEI 423

  Fly   189 VNLLSNDVGRFDLVLINVHYLWIAPLELIAVTYLMYLEIGISSMFG----VAIMLLFLPFQSYLG 249
            :|.::.|..|.......:|..|:..|::....:::|..:|::|:..    :.:||:..||    |
plant   424 INFMTVDAERIGNFSWYMHDPWMVLLQVGLALWILYRNLGLASIAALVATIIVMLINFPF----G 484

  Fly   250 KRTSVLRLRTALRTDERVRMMNEIISGIQVIKMYAWEKPF-GKVVEMTRFNEMLCIKQVNYIRGI 313
            :.....:.:.....|.|::..:||:..::::|:..||..| .|:.::.:..|....|.|  ....
plant   485 RMQERFQEKLMEAKDSRMKSTSEILRNMRILKLQGWEMKFLSKIFDLRKSEEGWLKKYV--YNSA 547

  Fly   314 LISFAMFLSRIFTS-SSLIAFVLLGNILNAEKAFFVTAYYNILRRSVTMFFPQGISEFAELLVSV 377
            :|||..:.:....| |:..|.:|||..|.:.|.....|.:.||:..: ...|..||...:..||:
plant   548 VISFVFWGAPTLVSVSTFGACILLGIPLESGKILSALATFRILQEPI-YNLPDTISMIVQTKVSL 611

  Fly   378 RRLEAFM----HRPETKVRDKSKVKNANQKAESPNGDSPKGNGIPENLIEFSQFQARWESHSLEP 438
            .||.:::    .:|:...|                  .|||:.  :..:|.......|:..|..|
plant   612 DRLASYLCLDNLQPDIVER------------------LPKGSS--DVAVEVINSTLSWDVSSSNP 656

  Fly   439 TLEDINLQLGRRKLVAVIGPVGAGKSSLIQAILGELPGESGTLRINGSYSYAAQEPWLFTGTVRQ 503
            ||:|||.::.....|||.|.||:|||||:.::|||:|..||:|::.|:.:|.||.||:.:|.:..
plant   657 TLKDINFKVFPGMKVAVCGTVGSGKSSLLSSLLGEVPKVSGSLKVCGTKAYVAQSPWIQSGKIED 721

  Fly   504 NILFGLDWDKHRYRTVVKKCALERDFELLPFGDKTIVGERGASLSGGQKARISLARAVYRRADIY 568
            |||||...::.||..|::.|:|.:|.|:|.|||:|::||||.:||||||.||.:|||:|:.||||
plant   722 NILFGKPMERERYDKVLEACSLSKDLEILSFGDQTVIGERGINLSGGQKQRIQIARALYQDADIY 786

  Fly   569 LLDDPLSAVDTHVGRHLFDQCMRGYLRSELVILVTHQLQFLEQADLIVIMDKGRISAMGTYSSMK 633
            |.|||.||||.|.|.|||.:.:.|.|.|:.||.||||::||..||||::|..||||..|.|:.:.
plant   787 LFDDPFSAVDAHTGSHLFKEVLLGLLCSKSVIYVTHQVEFLPAADLILVMKDGRISQAGKYNDIL 851

  Fly   634 RSGLDFAQLLTAPNK--------DAEDLDEIDGAGGDGL---DLLNV-PSLSRRGSKNSKPSTRN 686
            .||.||.:|:.|..:        ||..:.|....|.:.:   |.:.| ..|..:..||.|
plant   852 NSGTDFMELIGAHQEALAVVDSVDANSVSEKSALGQENVIVKDAIAVDEKLESQDLKNDK----- 911

  Fly   687 NSFTSLSSMAESMAQEASLQMQETRVEGKIGLGLYKEYLTSGSSWFMIFFMVFLCLATQILCSAA 751
                     .||:..:..:..:|.|.:|.:.|.:|.:|:|......::.|::...:..|:|...:
plant   912 ---------LESVEPQRQIIQEEEREKGSVALDVYWKYITLAYGGALVPFILLGQVLFQLLQIGS 967

  Fly   752 DYFLSYW---VDKNVDGQTDINTDPQDMYYFAALNVAVVVFTIVRTMLFYKMAMRSSTQLHNAMY 813
            :|::: |   |.::|.....::|   .|..:.||.....:..::|..|......:::|:|.:.|:
plant   968 NYWMA-WATPVSEDVQAPVKLST---LMIVYVALAFGSSLCILLRATLLVTAGYKTATELFHKMH 1028

  Fly   814 QGITRAAMYFFNTNPSGRILNRFSKDLGQLDEVLP----SVMLDVVQLFLTLLGIIVVIC-ITNP 873
            ..|.|:.|.||::.|||||::|.|.|...:|..||    ||.:.|:|    |:|||.|:. ::..
plant  1029 HCIFRSPMSFFDSTPSGRIMSRASTDQSAVDLELPYQFGSVAITVIQ----LIGIIGVMSQVSWL 1089

  Fly   874 YYLILTLALAIIFYYIREFYLKTSRDVKRLEAVARSPIYSHLSATITGLPTIRALGAQKELIAEF 938
            .:|:....:|...:|.| :|:..:|::.||..|.::|:..|.|.||:|..|||:...:....::.
plant  1090 VFLVFIPVVAASIWYQR-YYIAAARELSRLVGVCKAPLIQHFSETISGATTIRSFSQEFRFRSDN 1153

  Fly   939 DNLQDLHSSGYYTFLATNRAFGYYLDCFCTLYIVIIILNYFINPPQ---SPGEVGLAITQAMGMT 1000
            ..|.|.:|...:..........:.||...:|..|..:: :.::.|.   .|...|||:|..:.:.
plant  1154 MRLSDGYSRPKFYTAGAMEWLCFRLDMLSSLTFVFSLV-FLVSIPTGVIDPSLAGLAVTYGLSLN 1217

  Fly  1001 GMVQWAMRQSAELENTMTAVERVVEYDEIEPEGEFDSREGKKPSPSWPEKGEIIAEDLCLRYFPD 1065
            .:..|.:.....|||.:.:|||:::|..:..|... ..|..:|..|||.:||:...||.:||  .
plant  1218 TLQAWLIWTLCNLENKIISVERILQYASVPSEPPL-VIESNRPEQSWPSRGEVEIRDLQVRY--A 1279

  Fly  1066 PQAKYVLKALNFRIRPCEKVGIVGRTGAGKSSLINALFRL-SYNEGIITIDERDTADMGLFDLRS 1129
            |....||:.:....:...:.|||||||:|||:||..|||: ..:.|.|.||..:...:||.|||.
plant  1280 PHMPLVLRGITCTFKGGLRTGIVGRTGSGKSTLIQTLFRIVEPSAGEIRIDGVNILTIGLHDLRL 1344

  Fly  1130 KISIIPQEPVLFSGSMRYNLDPFEEYNDAKLWDALEEVKLKPLISELPNGLQSKISEGGSNFSVG 1194
            ::|||||:|.:|.|:||.||||.|||.|.::|:||::.:|...:.:....|.|.:||.|.|:|:|
plant  1345 RLSIIPQDPTMFEGTMRSNLDPLEEYTDDQIWEALDKCQLGDEVRKKEQKLDSSVSENGDNWSMG 1409

  Fly  1195 QRQLVCLARAILRENRVLVMDEATANVDPQTDALIQATIRSKFRDCTVLTIAHRLNTIMDSDRVL 1259
            |||||||.|.:|:.:::||:|||||:||..||.|||.|:|..|.||||:|||||:::::|||.||
plant  1410 QRQLVCLGRVLLKRSKILVLDEATASVDTATDNLIQKTLREHFSDCTVITIAHRISSVIDSDMVL 1474

  Fly  1260 VMDAGHLVEFGSPYELLTSSESKIFHGMVME---TGQNTFD 1297
            ::..|.:.|:.:|..|| ..:|..|..:|.|   ...::||
plant  1475 LLSNGIIEEYDTPVRLL-EDKSSSFSKLVAEYTSRSSSSFD 1514

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mrp4	NP_650086.2	CFTR_protein	12..1277	CDD:273530	420/1316 (32%)
		ABC_membrane	93..359	CDD:294371	61/274 (22%)
		ABCC_MRP_domain1	422..622	CDD:213217	100/199 (50%)
		ABC_membrane	735..978	CDD:294371	66/250 (26%)
		ABCC_MRP_domain2	1051..1272	CDD:213211	105/221 (48%)
ABCC3	NP_187915.1	MRP_assoc_pro	115..1499	CDD:188098	422/1324 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	99	1.000	Domainoid score	I2369
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H74563
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.720