DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mrp4 and ABCC4

DIOPT Version :9

Sequence 1:	NP_650086.2	Gene:	Mrp4 / 41387	FlyBaseID:	FBgn0263316	Length:	1316	Species:	Drosophila melanogaster
Sequence 2:	NP_182301.1	Gene:	ABCC4 / 819392	AraportID:	AT2G47800	Length:	1516	Species:	Arabidopsis thaliana

Alignment Length:	1316	Identity:	441/1316 - (33%)
Similarity:	712/1316 - (54%)	Gaps:	104/1316 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 SSPLSSLMFCFALPVLFKGRKKTLEQKDLYRALKEHKSDSLGDRLCAAWDEQVAKNETPRLGRAL 81
            :|..|...:.:..|:|.||.|..|..:.:.....|||::.|.....::|.:. ::|.:..:...|
plant   255 ASVFSKTFWLWMNPLLSKGYKSPLTLEQVPTLSPEHKAERLALLFESSWPKP-SENSSHPIRTTL 318

  Fly    82 TKVFGFHLFITGVFLLAQEFLTKVTQPICLIGVMAYFAGNDPDRSKAQLWAAGLIAGSVFSVCIG 146
            .:.|...:..|.:..:.:..:..| .|:.:...:.:.:|......:.......|:......|...
plant   319 LRCFWKEILFTAILAIVRLGVMYV-GPVLIQSFVDFTSGKRSSPWQGYYLVLILLVAKFVEVLTT 382

  Fly   147 HPYMLGLLHLGMKMRIALSSLIYRKALRLSRTALGDTTVGQVVNLLSNDVGRFDLVLINVHYLWI 211
            |.:......|||.:|..|.:.:|:|.|:|:.:|..:..|||:||.::.|..:...:::.:|.:|:
plant   383 HQFNFDSQKLGMLIRSTLITALYKKGLKLTGSARQNHGVGQIVNYMAVDAQQLSDMMLQLHAIWL 447

  Fly   212 APLELIAVTYLMYLEIGIS------SMFGVAIMLLFLPFQSYLGKRTSVLRLRTALRTDERVRMM 270
            .||::.....|:|..:|.|      .:.||.:.:| |..|...|.:.|::..|     |.|::..
plant   448 MPLQVTVALVLLYGSLGASVITAVIGLTGVFVFIL-LGTQRNNGYQFSLMGNR-----DSRMKAT 506

  Fly   271 NEIISGIQVIKMYAWEKPFGKVVEMTRFNEMLCIKQVNYIRGILISFA-----MFLSRIFTSSSL 330
            ||:::.::|||..|||..|.|  .:.:|.:|    :..::...|.|.|     ::.:.:..|:..
plant   507 NEMLNYMRVIKFQAWENHFNK--RILKFRDM----EFGWLSKFLYSIAGNIIVLWSTPVLISALT 565

  Fly   331 IAFVL-LGNILNAEKAFFVTAYYNILRRSVTMFFPQGISEFAELLVSVRRLEAFMHRPETKVRDK 394
            .|..| ||..|:|...|..|..:.||:..:.. |||.:...::.::|:.||:::|       ..|
plant   566 FATALALGVKLDAGTVFTTTTIFKILQEPIRT-FPQSMISLSQAMISLGRLDSYM-------MSK 622

  Fly   395 SKVKNANQKAESPNGDSPKGNGIPENLIEFSQFQARWESHSLEPTLEDINLQLGRRKLVAVIGPV 459
            ...::|.::|...:|::         .:|.......|:....||.|.|||.::.:.:|.|::|.|
plant   623 ELSEDAVERALGCDGNT---------AVEVRDGSFSWDDEDNEPALSDINFKVKKGELTAIVGTV 678

  Fly   460 GAGKSSLIQAILGELPGESGTLRINGSYSYAAQEPWLFTGTVRQNILFGLDWDKHRYRTVVKKCA 524
            |:|||||:.::|||:...||.:|:.||..|.||..|:..|||:.||||||...:.:|..|:..|:
plant   679 GSGKSSLLASVLGEMHRISGQVRVCGSTGYVAQTSWIENGTVQDNILFGLPMVREKYNKVLNVCS 743

  Fly   525 LERDFELLPFGDKTIVGERGASLSGGQKARISLARAVYRRADIYLLDDPLSAVDTHVGRHLFDQC 589
            ||:|.:::.|||||.:||||.:||||||.||.||||||:..|:|||||..||||.|.|..:|.:|
plant   744 LEKDLQMMEFGDKTEIGERGINLSGGQKQRIQLARAVYQECDVYLLDDVFSAVDAHTGSDIFKKC 808

  Fly   590 MRGYLRSELVILVTHQLQFLEQADLIVIMDKGRISAMGTYSSMKRSGLDFAQLLTAPNKDAEDLD 654
            :||.|:.:.|:|||||:.||...|.|::|..|:|...|.|..:..|||||.:|:.|.....|.::
plant   809 VRGALKGKTVLLVTHQVDFLHNVDCILVMRDGKIVESGKYDELVSSGLDFGELVAAHETSMELVE 873

  Fly   655 EIDGAGGDGLDLLNVP-------SLSRRGSKNSKPSTRNNSFTSLSSMAESMAQEAS-LQMQETR 711
                ||.|...:...|       :.|.|.|..|...:..|.....|.:...:.::.| |..:|.|
plant   874 ----AGADSAAVATSPRTPTSPHASSPRTSMESPHLSDLNDEHIKSFLGSHIVEDGSKLIKEEER 934

  Fly   712 VEGKIGLGLYKEYLTSGSSWFMIFFMVFLCLATQILCSAADYFLSYWVDKNVDGQTDINTDPQDM 776
            ..|::.||:||:|.|....|:.|..::|..|..|....|:||:|:|    ....:..|:.| ..:
plant   935 ETGQVSLGVYKQYCTEAYGWWGIVLVLFFSLTWQGSLMASDYWLAY----ETSAKNAISFD-ASV 994

  Fly   777 YYFAALNVAVVVFTIVRTMLFY--KMAMRSSTQLHNAMYQGITRAAMYFFNTNPSGRILNRFSKD 839
            :....:.:|:|...:|....:|  .:.::::......:...|..|.|.||:|.||||||:|.|.|
plant   995 FILGYVIIALVSIVLVSIRSYYVTHLGLKTAQIFFRQILNSILHAPMSFFDTTPSGRILSRASTD 1059

  Fly   840 LGQLDEVLPSVMLDVVQLFLTLLGIIVVICITNPY-----YLILTLALAIIFYYIREFYLKTSRD 899
            ...:|.::|.::..||.::.|||.|.:|.|   .|     :.::.|....|:|  |.:||.:||:
plant  1060 QTNVDILIPFMLGLVVSMYTTLLSIFIVTC---QYAWPTAFFVIPLGWLNIWY--RNYYLASSRE 1119

  Fly   900 VKRLEAVARSPIYSHLSATITGLPTIRALGAQKELIAE------FDNLQ-DLHSSGYYTFLATNR 957
            :.|::::.::||..|.|.:|.|:.|||:...| ||..:      .|||: |.|::|      :|.
plant  1120 LTRMDSITKAPIIHHFSESIAGVMTIRSFRKQ-ELFRQENVKRVNDNLRMDFHNNG------SNE 1177

  Fly   958 AFGYYLD-------CFCTLYIVIIILNYFINPPQSPGEVGLAITQAMGMTGMVQWAMRQSAELEN 1015
            ..|:.|:       |...|::|::..|..     .|..|||:::..:.:..::.:|:..|..:||
plant  1178 WLGFRLELVGSWVLCISALFMVLLPSNVI-----RPENVGLSLSYGLSLNSVLFFAIYMSCFVEN 1237

  Fly  1016 TMTAVERVVEYDEIEPEGEFDSREGKKPSPSWPEKGEIIAEDLCLRYFPDPQAKYVLKALNFRIR 1080
            .|.:|||:.::.:|..|.|::.:|...|| :||..|.:..|||.:||  .|....|||.:...|:
plant  1238 KMVSVERIKQFTDIPSESEWERKETLPPS-NWPFHGNVHLEDLKVRY--RPNTPLVLKGITLDIK 1299

  Fly  1081 PCEKVGIVGRTGAGKSSLINALFRL-SYNEGIITIDERDTADMGLFDLRSKISIIPQEPVLFSGS 1144
            ..||||:|||||:|||:||..|||| ..:.|.|.||..|.:.:||.||||:..|||||||||.|:
plant  1300 GGEKVGVVGRTGSGKSTLIQVLFRLVEPSGGKIIIDGIDISTLGLHDLRSRFGIIPQEPVLFEGT 1364

  Fly  1145 MRYNLDPFEEYNDAKLWDALEEVKLKPLISELPNGLQSKISEGGSNFSVGQRQLVCLARAILREN 1209
            :|.|:||.|:|:|.::|.:||..:||.:::..|..|.|.:.:.|.|:|||||||:||.|.:|:.:
plant  1365 VRSNIDPTEQYSDEEIWKSLERCQLKDVVATKPEKLDSLVVDNGENWSVGQRQLLCLGRVMLKRS 1429

  Fly  1210 RVLVMDEATANVDPQTDALIQATIRSKFRDCTVLTIAHRLNTIMDSDRVLVMDAGHLVEFGSPYE 1274
            |:|.:|||||:||.||||:||..||..|..||:::||||:.|:||.|||||:|||...||.||..
plant  1430 RLLFLDEATASVDSQTDAVIQKIIREDFASCTIISIAHRIPTVMDGDRVLVIDAGKAKEFDSPAR 1494

  Fly  1275 LLTSSESKIFHGMVME 1290
            ||  ....:|..:|.|
plant  1495 LL--ERPSLFAALVQE 1508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mrp4	NP_650086.2	CFTR_protein	12..1277	CDD:273530	437/1301 (34%)
		ABC_membrane	93..359	CDD:294371	66/277 (24%)
		ABCC_MRP_domain1	422..622	CDD:213217	96/199 (48%)
		ABC_membrane	735..978	CDD:294371	73/263 (28%)
		ABCC_MRP_domain2	1051..1272	CDD:213211	115/221 (52%)
ABCC4	NP_182301.1	CFTR_protein	255..1502	CDD:273530	438/1308 (33%)
		ABC_membrane	331..595	CDD:294371	66/276 (24%)
		ABCC_MRP_domain1	641..841	CDD:213217	96/199 (48%)
		ABC_membrane	976..1229	CDD:294371	73/274 (27%)
		ABCC_MRP_domain2	1272..1492	CDD:213211	115/221 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	99	1.000	Domainoid score	I2369
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.720