DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mrp4 and ABCC2

DIOPT Version :9

Sequence 1:	NP_650086.2	Gene:	Mrp4 / 41387	FlyBaseID:	FBgn0263316	Length:	1316	Species:	Drosophila melanogaster
Sequence 2:	NP_001189675.1	Gene:	ABCC2 / 818031	AraportID:	AT2G34660	Length:	1623	Species:	Arabidopsis thaliana

Alignment Length:	1341	Identity:	460/1341 - (34%)
Similarity:	716/1341 - (53%)	Gaps:	105/1341 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 PRERSSPLSSLMFCFALPVLFKGRKKTLEQKDLYRALKEHKSDSLGDRLCAAWDEQVAKNETPRL 77
            |.:.::....:.|.:..|::..|.|:.|.:||::......::::|......:||:::.|.: |.|
plant   227 PEKHANIFDKIFFSWMNPLMTLGSKRPLTEKDVWYLDTWDQTETLFTSFQHSWDKELQKPQ-PWL 290

  Fly    78 GRALTKVFGFHLFITGVFLLAQEFLTKVTQPICLIGVMAYFAGNDPDRSKAQLWAAGLIAGSVFS 142
            .|||....|...:..|.:.:..: .::...|: |:..:......|.......::|..:..|.||.
plant   291 LRALNNSLGGRFWWGGFWKIGND-CSQFVGPL-LLNQLLKSMQEDAPAWMGYIYAFSIFVGVVFG 353

  Fly   143 VCIGHPYMLGLLHLGMKMRIALSSLIYRKALRLSRTALGDTTVGQVVNLLSNDVGRFDLVLINVH 207
            |.....|...::.:|.::|.||.:.::||:|||:.........|::.||::.|......:..::|
plant   354 VLCEAQYFQNVMRVGYRLRSALIAAVFRKSLRLTNEGRRKFQTGKITNLMTTDAESLQQICQSLH 418

  Fly   208 YLWIAPLELIAVTYLMYLEIGISSMFGVAIMLLFLPFQSYLGKRTSVLRLRTALRTDERVRMMNE 272
            .:|.||..:|....|:|.::|::|:.|..:::|..|.|:.:..:...|......|||:|:.:|||
plant   419 TMWSAPFRIIIALILLYQQLGVASLIGALLLVLMFPLQTVIISKMQKLTKEGLQRTDKRIGLMNE 483

  Fly   273 IISGIQVIKMYAWEKPFGKVVEMTRFNEMLCIKQVNYIRGILISFAMFLSRIFTSSSLIAFVLLG 337
            :::.:..:|.||||..|...|:..|.:|:...::...:..:.:.....:..:.|..|...|.|||
plant   484 VLAAMDTVKCYAWENSFQSKVQTVRDDELSWFRKSQLLGALNMFILNSIPVLVTIVSFGVFTLLG 548

  Fly   338 NILNAEKAFFVTAYYNILRRSVTMFFPQGISEFAELLVSVRRLEAFMHRPETKVRDKSKVKNANQ 402
            ..|...:||...:.:.:||..:.| .|..|::.....||::|||              :|....:
plant   549 GDLTPARAFTSLSLFAVLRFPLFM-LPNIITQVVNANVSLKRLE--------------EVLATEE 598

  Fly   403 KAESPNGDSPKGNGIPENLIEFSQFQARWESHSLEPTLEDINLQLGRRKLVAVIGPVGAGKSSLI 467
            :...||  .|...|.|...|....|.  |:|....|||.:|||.:....||||:|..|.||:|||
plant   599 RILLPN--PPIEPGEPAISIRNGYFS--WDSKGDRPTLSNINLDVPLGSLVAVVGSTGEGKTSLI 659

  Fly   468 QAILGELPGESGTL-RINGSYSYAAQEPWLFTGTVRQNILFGLDWDKHRYRTVVKKCALERDFEL 531
            .|||||||..|..: .:.||.:|..|..|:|..|||.|||||..:|:.:|...:...:|:.|.||
plant   660 SAILGELPATSDAIVTLRGSVAYVPQVSWIFNATVRDNILFGSPFDREKYERAIDVTSLKHDLEL 724

  Fly   532 LPFGDKTIVGERGASLSGGQKARISLARAVYRRADIYLLDDPLSAVDTHVGRHLFDQCMRGYLRS 596
            ||.||.|.:||||.::|||||.|:|:|||||..:|:|:.||||||:|.|||:.:|::|::..|..
plant   725 LPGGDLTEIGERGVNISGGQKQRVSMARAVYSNSDVYIFDDPLSALDAHVGQQVFEKCIKRELGQ 789

  Fly   597 ELVILVTHQLQFLEQADLIVIMDKGRISAMGTYSSMKRSGLDFAQLLTAPNKDAEDLDEIDG--- 658
            :..:|||:||.||.|.|.||::.:|.:...|||..:..:|..|.:|:....| .|:..|.:|
plant   790 KTRVLVTNQLHFLSQVDRIVLVHEGTVKEEGTYEELSSNGPLFQRLMENAGK-VEEYSEENGEAE 853

  Fly   659 ---------AGGDGLDLLNVPSLSRRGSKNSKPSTRNNSFTSLSSMAESMAQEASLQMQETRVEG 714
                     |.|      |...|...||.:.|....|..           ..::.|..||.|..|
plant   854 ADQTAEQPVANG------NTNGLQMDGSDDKKSKEGNKK-----------GGKSVLIKQEERETG 901

  Fly   715 KIGLGLYKEYLTS-GSSWFMIFFMVFLC-LATQILCSAADYFLSYWVDKNVDGQTDINTDPQDMY 777
            .:...:.|.|..: |.:|  :..|:.|| :.|::....:..:||.|.|..    |..:..|  ::
plant   902 VVSWRVLKRYQDALGGAW--VVMMLLLCYVLTEVFRVTSSTWLSEWTDAG----TPKSHGP--LF 958

  Fly   778 Y---FAALNVAVVVFTIVRTMLFYKMAMRSSTQLHNAMYQGITRAAMYFFNTNPSGRILNRFSKD 839
            |   :|.|:...|:.|:..:......::.::.:||:.|...|.||.|.||:|||.|||:|||:||
plant   959 YNLIYALLSFGQVLVTLTNSYWLIMSSLYAAKKLHDNMLHSILRAPMSFFHTNPLGRIINRFAKD 1023

  Fly   840 LGQLDEVLPSVMLDVVQLFL----TLLGIIVVICITNPYYLILTLALAIIFYYIREFYLKTSRDV 900
            ||.:|..:..    .|.:|:    .||..:|:|.|.:...|...:.|.::||....:|..|:|:|
plant  1024 LGDIDRTVAV----FVNMFMGQVSQLLSTVVLIGIVSTLSLWAIMPLLVLFYGAYLYYQNTAREV 1084

  Fly   901 KRLEAVARSPIYSHLSATITGLPTIRALGAQKELIAEFDNLQDLHSSGY-----YTF--LATNRA 958
            ||:::::|||:|:.....:.||.||||..|       :|.:.|::....     :|.  :..||.
plant  1085 KRMDSISRSPVYAQFGEALNGLSTIRAYKA-------YDRMADINGRSMDNNIRFTLVNMGANRW 1142

  Fly   959 FGYYLDCFCTLYIVIIILNYFI-------NPPQSPGEVGLAITQAMGMTGMVQWAMRQSAELENT 1016
            .|..|:....| ::.:..::.:       |.......:||.::.|:.:|.::...:|.::..||:
plant  1143 LGIRLETLGGL-MIWLTASFAVMQNGRAENQQAFASTMGLLLSYALNITSLLTGVLRLASLAENS 1206

  Fly  1017 MTAVERVVEYDEIEPEGEFDSREGKKPSPSWPEKGEIIAEDLCLRYFPDPQAKYVLKALNFRIRP 1081
            :.|||||..|.||.||.. ...|..:|.|.||..|.|..||:.|||  .||...||..::|.|.|
plant  1207 LNAVERVGNYIEIPPEAP-PVIENNRPPPGWPSSGSIKFEDVVLRY--RPQLPPVLHGVSFFIHP 1268

  Fly  1082 CEKVGIVGRTGAGKSSLINALFRL-SYNEGIITIDERDTADMGLFDLRSKISIIPQEPVLFSGSM 1145
            .:|||||||||||||||:|||||: ...:|.|.||:.|....||.|||..:.||||.||||||::
plant  1269 TDKVGIVGRTGAGKSSLLNALFRIVEVEKGRILIDDCDVGKFGLMDLRKVLGIIPQSPVLFSGTV 1333

  Fly  1146 RYNLDPFEEYNDAKLWDALEEVKLKPLISELPNGLQSKISEGGSNFSVGQRQLVCLARAILRENR 1210
            |:|||||.|:|||.||::||...||..|...|.||.:::||.|.|||||||||:.|:||:||.::
plant  1334 RFNLDPFGEHNDADLWESLERAHLKDTIRRNPLGLDAEVSEAGENFSVGQRQLLSLSRALLRRSK 1398

  Fly  1211 VLVMDEATANVDPQTDALIQATIRSKFRDCTVLTIAHRLNTIMDSDRVLVMDAGHLVEFGSPYEL 1275
            :||:|||||.||.:||||||.|||.:|:.||:|.||||||||:|.|::||:|:|.:.||.||..|
plant  1399 ILVLDEATAAVDVRTDALIQKTIREEFKSCTMLIIAHRLNTIIDCDKILVLDSGRVQEFSSPENL 1463

  Fly  1276 LTSSESKIFHGMVMETGQNTFDSLLKVAEKAHLESMKPKSE 1316
            | |:|...|..||..||....:.|..:.    |::.:.|.:
plant  1464 L-SNEGSSFSKMVQSTGAANAEYLRSLV----LDNKRAKDD 1499

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mrp4	NP_650086.2	CFTR_protein	12..1277	CDD:273530	449/1300 (35%)
		ABC_membrane	93..359	CDD:294371	64/265 (24%)
		ABCC_MRP_domain1	422..622	CDD:213217	96/200 (48%)
		ABC_membrane	735..978	CDD:294371	74/257 (29%)
		ABCC_MRP_domain2	1051..1272	CDD:213211	129/221 (58%)
ABCC2	NP_001189675.1	PLN03130	1..1623	CDD:215595	460/1341 (34%)
		ABC_membrane	309..570	CDD:279056	63/262 (24%)
		ABCC_MRP_domain1	614..815	CDD:213217	96/202 (48%)
		ABC_membrane	925..1179	CDD:294371	74/271 (27%)
		ABCC_MRP_domain2	1240..1460	CDD:213211	129/221 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	179	1.000	Domainoid score	I1056
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.720