DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mrp4 and Abcc6

DIOPT Version :9

Sequence 1:	NP_650086.2	Gene:	Mrp4 / 41387	FlyBaseID:	FBgn0263316	Length:	1316	Species:	Drosophila melanogaster
Sequence 2:	NP_112275.1	Gene:	Abcc6 / 81642	RGDID:	620268	Length:	1502	Species:	Rattus norvegicus

Alignment Length:	1363	Identity:	451/1363 - (33%)
Similarity:	687/1363 - (50%)	Gaps:	141/1363 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 DELPENP---RERSSPLSSLMFCFALPVLFKGRKKTLEQKDLYRALKEHKSDSLGDRLCAAWDE- 67
            |..|.||   .|.|.| |..||.:|..:|:||.:|.|..|||:...:|:.|:.|..:|...|..
  Rat   202 DSKPLNPCPEAEASFP-SKAMFWWASGLLWKGYRKLLGPKDLWSLERENSSEELVSQLEREWRRN 265

  Fly    68 ----------------------QVAKNETPRLGRALTKVFGFHLFITGV--FLLAQEFLTKVTQP 108
                                  |..:::...|.||:.:||. ..|:.|.  .:::..|...|.:
  Rat   266 FSELPGHKGHSGMGTPETEAFLQPERSQRGPLLRAIWRVFR-STFLLGTLSLVISDAFRFAVPK- 328

  Fly   109 ICLIGVMAYFAGNDPDRSKAQLWAAGLIAGSVF-SVCI----GHPYMLGLLHLGMKMRIALSSLI 168
              |:.:...|.|:    .::..|...|:|..:| |.|:    ...||..:..|.|::|.|::.|:
  Rat   329 --LLSLFLEFMGD----LESSAWTGWLLAVLMFLSACLQTLFEQQYMYRVKVLQMRLRTAITGLV 387

  Fly   169 YRKALRLSRTALGDTTVGQVVNLLSNDVGRFDLVLINVHYLWIAPLELIAVTYLMYLEIGISSMF 233
            |||.|.||..:...:..|.||||:|.||.|....:::::.||:..|.:|.....::..:|.|::.
  Rat   388 YRKVLVLSSGSRKSSAAGDVVNLVSVDVQRLVESILHLNGLWLLFLWIIVCFVYLWQLLGPSALT 452

  Fly   234 GVAIMLLFLPFQSYLGKRTSVLRLRTALRTDERVRMMNEIISGIQVIKMYAWEKPFGKVVEMTRF 298
            .||:.|..||...::.|:.|..:.....:...|.|:.:.::..::.||.:.||..|.:.:...|.
  Rat   453 AVAVFLSLLPLNFFITKKRSFHQEEQMRQKASRARLTSSMLRTVRTIKSHGWECAFLERLLHIRG 517

  Fly   299 NEMLCIKQVNYIRGI-LISFAMFLSRIFTSSSLIAFVLLG--------NILNAEKAFFVTAYYNI 354
            .|:..:|...::..: |:||.:       |:.|:|.|:..        |.::|||||......:|
  Rat   518 QELGALKTSAFLFSVSLVSFQV-------STFLVALVVFAVHTLVAEDNAMDAEKAFVTLTVLSI 575

  Fly   355 LRRSVTMFFPQGISEFAELLVSVRRLEAFMHRPETKVRDKSKVKNANQKAESPNGDSPKGNGIPE 419
            |.:: ..|.|..:....:..||..||.||:...|.         :.|....||:..|.|
  Rat   576 LNKA-QAFLPFSVHCLVQARVSFDRLAAFLCLEEV---------DPNGMVLSPSRCSSK------ 624

  Fly   420 NLIEFSQFQARWESHSLEPTLEDINLQLGRRKLVAVIGPVGAGKSSLIQAILGELPGESGTLRIN 484
            :.|........|...| .|.|..|||.:.:..|:||:||||||||||:.|:||||....|::.|.
  Rat   625 DRISIHNGTFAWSQES-PPCLHGINLTVPQGCLLAVVGPVGAGKSSLLSALLGELLKVEGSVSIE 688

  Fly   485 GSYSYAAQEPWLFTGTVRQNILFGLDWDKHRYRTVVKKCALERDFELLPFGDKTIVGERGASLSG 549
            ||.:|..||.|:...:|.:|:.|..:.|....:.|::.|||..|....|.|..|.|||:|.:|||
  Rat   689 GSVAYVPQEAWVQNTSVVENVCFRQELDLPWLQEVLEACALGSDVASFPAGVHTPVGEQGMNLSG 753

  Fly   550 GQKARISLARAVYRRADIYLLDDPLSAVDTHVGRHLFDQCM--RGYLRSELVILVTHQLQFLEQA 612
            |||.|:||||||||||.:||:||||:|:|.||.:.:|.|.:  .|.|:....|||||.|..|.||
  Rat   754 GQKQRLSLARAVYRRAAVYLMDDPLAALDAHVSQEVFKQVIGPSGLLQGTTRILVTHTLHVLPQA 818

  Fly   613 DLIVIMDKGRISAMGTYSS-MKRSG-----LDFAQLLTAPNKD----AEDLDEIDGAGGDGLDLL 667
            |.|:::..|.|:.||:|.. :.|:|     ||.|:......:.    |...|::.|..|.|
  Rat   819 DQILVLANGTIAEMGSYQDLLHRNGALVGLLDGARQPAGEGEGEAHAAATSDDLGGFSGGG---- 879

  Fly   668 NVPSLSRRGSKNSKPSTRN--NSFTSLSSMAESM--AQEASLQMQETRVE-GKIGLGLYKEYLTS 727
             .|:   |..:..:||...  ...||.:.|..|:  .:...|...|..|: |::....|..||.:
  Rat   880 -TPT---RRPERPRPSDAAPVKGSTSEAQMEPSLDDVEVTGLTAGEDSVQYGRVKSATYLSYLRA 940

  Fly   728 -GSSWFMIFFMVFLCLATQILCSAADYFLSYWVDKNVDGQTDINTDPQDMYYFAALNVAVVVFTI 791
             |:.  :..:.:||.|..|:......|:||.|.|..|       .|.:.|:  :||..:  :|.:
  Rat   941 VGTP--LCTYTLFLFLCQQVASFCQGYWLSLWADDPV-------VDGKQMH--SALRGS--IFGL 992

  Fly   792 VRTM----LFYKMA------MRSSTQLHNAMYQGITRAAMYFFNTNPSGRILNRFSKDLGQLDEV 846
            :..:    ||..||      .|:|..|..::...:.|:.:.||...|.|.:||||||:...:|..
  Rat   993 LGCLQAIGLFASMAAVFLGGARASCLLFRSLLWDVARSPIGFFERTPVGNLLNRFSKETDIVDVD 1057

  Fly   847 LPSVMLDVVQLFLTLLGIIVVICITNPYYLILTLALAIIFYYIREFYLKTSRDVKRLEAVARSPI 911
            :|..|..::.....||.:.:.:.:..|..::..|.|.:::...:..|:.|...::|||:.:.|.:
  Rat  1058 IPDKMRTLLTYAFGLLEVGLAVSMATPLAIVAILPLMLLYAGFQSLYVATCCQLRRLESASYSSV 1122

  Fly   912 YSHLSATITGLPTIRALGAQKELIAEFDNLQDLHSSGYYTFLATNRAFGYYLDCFCT-LYIVIII 975
            .|||:.|..|...:||..||....|:.|.|.|.:....:..|..:|.....|:.... |..|...
  Rat  1123 CSHLAETFQGSQVVRAFQAQGPFTAQHDALMDENQRISFPRLVADRWLAANLELLGNGLVFVAAT 1187

  Fly   976 LNYFINPPQSPGEVGLAITQAMGMTGMVQWAMRQSAELENTMTAVERVVEYDEIEPEGEFDSREG 1040
            .........|.|..|.:::.|:.:|..:||.:|...:|||:|.|||||.:|.....|..:
  Rat  1188 CAVLSKAHLSAGLAGFSVSAALQVTQTLQWVVRSWTDLENSMVAVERVQDYVHTPKEAPW----- 1247

  Fly  1041 KKPS----PSWPEKGEIIAEDLCLRYFPD-PQAKYVLKALNFRIRPCEKVGIVGRTGAGKSSLIN 1100
            :.||    |.||..|:|...|..||:.|: |.|   ::.::.:|...||||||||||||||||..
  Rat  1248 RLPSSAAQPLWPCGGQIEFRDFGLRHRPELPMA---VQGVSLKIHAGEKVGIVGRTGAGKSSLTW 1309

  Fly  1101 ALFRL-SYNEGIITIDERDTADMGLFDLRSKISIIPQEPVLFSGSMRYNLDPFEEYNDAKLWDAL 1164
            .|.|| ...||.|.||.....||||..|||:|:||||:||||.||:|.|||..:|..|..:|.||
  Rat  1310 GLLRLQEATEGGIWIDGVPITDMGLHTLRSRITIIPQDPVLFPGSLRMNLDLLQENTDEGIWAAL 1374

  Fly  1165 EEVKLKPLISELPNGLQSKISEGGSNFSVGQRQLVCLARAILRENRVLVMDEATANVDPQTDALI 1229
            |.|:||..::.||..||.:.|..|.:.||||:||:|||||:||:.::|::|||||:|||.|:..:
  Rat  1375 ETVQLKAFVTSLPGQLQYECSGQGDDLSVGQKQLLCLARALLRKTQILILDEATASVDPGTEIQM 1439

  Fly  1230 QATIRSKFRDCTVLTIAHRLNTIMDSDRVLVMDAGHLVEFGSPYELLTSSESKIFHGMVMETG 1292
            ||.:...|..||||.|||||.::|:..||||||.|.:.|.|||.:||  ::..:|:.:..|:|
  Rat  1440 QAALERWFAQCTVLLIAHRLRSVMNCARVLVMDEGQVAESGSPAQLL--AQKGLFYRLAQESG 1500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mrp4	NP_650086.2	CFTR_protein	12..1277	CDD:273530	445/1341 (33%)
		ABC_membrane	93..359	CDD:294371	72/281 (26%)
		ABCC_MRP_domain1	422..622	CDD:213217	92/201 (46%)
		ABC_membrane	735..978	CDD:294371	65/253 (26%)
		ABCC_MRP_domain2	1051..1272	CDD:213211	115/222 (52%)
Abcc6	NP_112275.1	MRP_assoc_pro	36..1501	CDD:188098	451/1363 (33%)
		ABC_membrane	313..577	CDD:294371	70/277 (25%)
		ABCC_MRP_domain1	627..828	CDD:213217	92/201 (46%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	854..909		12/62 (19%)
		ABC_membrane	950..1215	CDD:294371	70/275 (25%)
		ABCC_MRP_domain2	1262..1482	CDD:213211	115/222 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345097
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.650