Protein Alignment Mrp4 and abcb11a

DIOPT Version :9

• Sequence 1: NP_650086.2
• Gene: Mrp4 / 41387
• FlyBaseID: FBgn0263316
• Length: 1316
• Species: Drosophila melanogaster
• Sequence 2: XP_009303249.2
• Gene: abcb11a / 797269
• ZFINID: ZDB-GENE-050517-13
• Length: 1320
• Species: Danio rerio
• Alignment Length: 1356
• Identity: 305/1356 - (22%)
• Similarity: 558/1356 - (41%)
• Gaps: 261/1356 - (19%)

  Fly    84 VFGFHLFITGVFLLAQEFLTKVTQP--ICLIGVMAYFAGN---DPDRSKAQLWA---AGLIAGSV 140
            |:|   .:|..|:..:..:.::|.|  .|:...:::..|:   .||.:......   |.:...::
Zfish    75 VYG---MMTNTFVEYEVEILELTDPNKTCINNTISWMNGSAVQRPDNTTIYCGVDIEAEMTNFAL 136

  Fly   141 FSVCIGHPYMLGLLHLGMKMRIALSSLIYRKALRLSRTALGD-----------TTVGQVVNLLSN 194
            :.:.||    :|:|.|.........|...|:..|:.:|....           .:||::...:|:
Zfish   137 YYIGIG----VGVLILSFFQITFWVSAAARQIQRIRKTYFRKIMCMEIGWFDCNSVGELNTRMSD 197

  Fly   195 DVGRFDLVLINVHYLWIAPLELIAVTYLMYLEIGISSMFGVAIMLLFLPFQSYLGKRTSVLRLRT 259
            |:.:.:..:.:...::|..:.    |::....:|.  :.|..:.|:.:.....||....::.:..
Zfish   198 DINKINNAIADQVSIFIERIS----TFIFGFMVGF--IGGWKLTLVVIAVSPLLGLAAGLMAMAV 256

  Fly   260 ALRTDERVR-------MMNEIISGIQVIKMYAWEKPFGKVVEMTRFNEMLCIKQVNYI-RGILIS 316
            |..|...::       :.:|::|.|:.:..:.     |:..|..|::..|...|...| :|::|.
Zfish   257 ARLTGRELKAYAKAGAVADEVLSSIRTVAAFG-----GEHKEAERYDRNLVQAQEWGIKKGMIIG 316

  Fly   317 -FAMFLSRIFTSSSLIAFVLLGNILNAEKAFFVTAYYNILRRSVTMFFPQGISE-FAELLVSVRR 379
             |..:|..|.    .:.:.|         ||:..:...|..:.:|   |.|:.: |..:|:....
Zfish   317 VFQGYLWCII----FLCYAL---------AFWFGSKLVIETQELT---PGGLVQVFFGVLIGAMN 365

  Fly   380 -------LEAFMHRPETKVRDKSKVKNANQKAE----SPNG---DSPKGNGIPENLIEFSQFQAR 430
                   ||||   ...:...||.....:::.|    |..|   |..||:      |||......
Zfish   366 LGQASPCLEAF---ASGRAAAKSIFDTIDREPEIDCFSDEGHTLDKVKGD------IEFHSVNFN 421

  Fly   431 WESHSLEPTLEDINLQLGRRKLVAVIGPVGAGKSSLIQAILGELPGESGTLRINGS--------- 486
            :.|......|:|:|:.:...:..|.:||.|:||::.||.|........|.:.::|.
Zfish   422 YPSRPEVKILDDLNIVVKAGETTAFVGPSGSGKTTTIQLIQRFYDPSEGMVSLDGHDIRSLNIQW 486

  Fly   487 ----YSYAAQEPWLFTGTVRQNILFGLDWDKHRYRTVVKKCALERDFEL-LPFGDKTIVGERGAS 546
                .....|||.||..|:.:||.:|......:......|.|...:|.: ||....|:|||.|..
Zfish   487 LRSLIGVVEQEPVLFATTIAENIRYGRAGVTMQEIIEAAKQANAYNFIMSLPQTFDTLVGEGGGQ 551

  Fly   547 LSGGQKARISLARAVYRRADIYLLDDPLSAVDTH---VGRHLFDQCMRGYLRSELVILVTHQLQF 608
            :|||||.||::|||:.|...|.|||...||:|..   |.:...|:..:|    ...|.:.|:|..
Zfish   552 MSGGQKQRIAIARALVRNPRILLLDMATSALDNESEAVVQEALDKARQG----RTTISIAHRLST 612

  Fly   609 LEQADLIVIMDKGRISAMGTYSS-MKRSGLDFAQLLTAPNKDAE-DLDEIDGAGGDGL-DLLNVP 670
            :..||:||..:.||....||:|. :.:.|:.|. |:|..|:..: |.|:.:......: :...:.
Zfish   613 IRNADVIVGFEHGRAVERGTHSQLLDKKGVYFT-LVTLQNQGKDTDTDKPENTAESRVTEEAELE 676

  Fly   671 SLSRRGSKNSKPSTRNNSFTSLSSMAESMAQEAS-----LQMQETRVEGKIGLGLYKE------- 723
            .|.|..|.:.:...|..|.:.||:....::.:..     .:|:|:. ..|...|..||
Zfish   677 ELRRFSSGSYESVLRRRSLSQLSNSLSVISGKFDFNSDLFEMEESD-NNKKSKGKAKEDIKPAPV 740

  Fly   724 ------------YLTSGSSWFMI---FFMVFLCLATQILCSAADYFLSYWVDKNVDGQTDINTDP 773
                        |:..||....|   ...::..|.:|||                 |...| .||
Zfish   741 ARILKYNRPEWPYMLLGSIGAAINGSLNPMYALLFSQIL-----------------GTFSI-PDP 787

  Fly   774 QDMYYFAALNVAVVVFTIVRTMLFYKMAMRS----------STQLHNAMYQGITRAAMYFFN--T 826
            .|..  ..:|...::|.::..:.|:...::.          :.:|....:|.:.:..:.:|:  .
Zfish   788 DDQR--RQINGICILFVVIGVVSFFSQFLQGYSFAKSGELLTRRLRKFGFQAMLKQEIGWFDDPM 850

  Fly   827 NPSGRILNRFSKDLGQLDEVLPSVMLDVVQLFLTLLGIIVVICITNPYY------LILTLALAII 885
            |..|.:..|.:.:...:.....| .:.::...||.:|...:|.    ||      |::|..|.:|
Zfish   851 NSPGALTTRLATNASMVQGATGS-QIGMIVNSLTNIGASFIIA----YYFSWKLSLVVTCFLPLI 910

  Fly   886 ----FYYIREFYLKTSRDVKRLEAVARSPIYSHLSATITGLPTIRALGAQKELIAEFD-NLQDLH 945
                .:..:......:.|...|||..:..     |..::.:.||..|..:|..:|:|: .||..:
Zfish   911 GLSGVFQSKMLTGLANEDKTALEAAGQVS-----SEAMSNIRTIAGLAKEKHFVAQFEKQLQAPY 970

  Fly   946 SSGYYTFLATNRAFGYYLDCFCTLYIVIIIL--------NYFINPPQSPGEVGL----------- 991
            .:      |..:|:.|.: ||.....||.:.        .|.::      ..||
Zfish   971 KA------AKKKAYVYGI-CFAFARCVIFMAYAASFRYGGYLVS------HEGLQYMMVFRVISA 1022

  Fly   992 ------AITQAMGMTGMVQWAMRQSAELENTMTAVERVVEYDEIEPEGEFDSREGKKPSPSWPE- 1049
                  |:.:|...|.....|...:|:|   ...::||.:.:..:.||:           ||.:
Zfish  1023 LVTSATALGRASSFTPDYAKAKISAAQL---FQLLDRVPKINVSKTEGQ-----------SWNDF 1073

  Fly  1050 KGEIIAEDLCLRYFPDPQAKYVLKALNFRIRPCEKVGIVGRTGAGKSSLINALFRL-SYNEGIIT 1113
            ||::..:. |...:|......||:.|...:.|.:.:..||.:|.|||:.:..|.|. ..:||.:.
Zfish  1074 KGKVEFKG-CRFTYPSRPDVQVLRGLVVSVHPGQTLAFVGSSGCGKSTSVQLLERFYDPDEGQVL 1137

  Fly  1114 IDERDTADMGLFDLRSKISIIPQEPVLFSGSMRYNLDPFEEYND-------AKLWDALEEVKLKP 1171
            ||.|.:..:.:..|||:|.|:.||||||..|:..|:    :|.|       .::.||.::..|..
Zfish  1138 IDGRPSDSISVPFLRSQIGIVSQEPVLFDCSIAENI----QYGDNSRTVSMEEIIDAAKKAYLHD 1198

  Fly  1172 LISELPNGLQSKISEGGSNFSVGQRQLVCLARAILRENRVLVMDEATANVDPQTDALIQATIRSK 1236
            .:..||:..::::...||..|.||:|.:.:||||:|..::|::||||:.:|.:::..:||.:...
Zfish  1199 FVMTLPDKYETQVGAQGSQLSRGQKQRIAIARAIVRNPKILLLDEATSALDTESEKTVQAALDEA 1263

  Fly  1237 FRDCTVLTIAHRLNTIMDSDRVLVMDAGHLVEFGSPYELLTSSESKIFHGMVMETG 1292
            .:..|.:.|||||:||..:|.:.||..|.::|.|:..||:.   .|..:..::.||
Zfish  1264 RQGRTCIVIAHRLSTIQSADIIAVMSQGEVIEKGTHDELMA---KKAAYYKLVTTG 1316

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mrp4	NP_650086.2	CFTR_protein	12..1277	CDD:273530	302/1339 (23%)
		ABC_membrane	93..359	CDD:294371	48/293 (16%)
		ABCC_MRP_domain1	422..622	CDD:213217	65/216 (30%)
		ABC_membrane	735..978	CDD:294371	49/273 (18%)
		ABCC_MRP_domain2	1051..1272	CDD:213211	73/228 (32%)
abcb11a	XP_009303249.2	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000