DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mrp4 and ABCC8

DIOPT Version :9

Sequence 1:	NP_650086.2	Gene:	Mrp4 / 41387	FlyBaseID:	FBgn0263316	Length:	1316	Species:	Drosophila melanogaster
Sequence 2:	XP_016873686.1	Gene:	ABCC8 / 6833	HGNCID:	59	Length:	1604	Species:	Homo sapiens

Alignment Length:	1456	Identity:	441/1456 - (30%)
Similarity:	727/1456 - (49%)	Gaps:	232/1456 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 ENPRERSSP--LSSLMFCFALP---VLFKG------------RKKTLEQKDL------YRALKEH 52
            :.|||...|  |..|...|..|   :|.||            .||.::.:.:      .|||..:
Human   199 KTPREVKPPEDLQDLGVRFLQPFVNLLSKGTYWWMNAFIKTAHKKPIDLRAIGKLPIAMRALTNY 263

  Fly    53 KSDSLGDRLCAAWDEQVAKNETPRLG-----RALTKVFGFHLFITGVFLLAQEFLTKVTQPICLI 112
            :      |||.|:|.||.|:.....|     :||:..||..|.::..|.:..:.| ....|:|:.
Human   264 Q------RLCEAFDAQVRKDIQGTQGARAIWQALSHAFGRRLVLSSTFRILADLL-GFAGPLCIF 321

  Fly   113 GVMAYFA-GNDPDRSKAQLWAAGLIAGSVFSVCIGHPYMLGLL--------------------HL 156
            |::.:.. .||..:.|.|......::...|   :.:.|:|.:|                    ..
Human   322 GIVDHLGKENDVFQPKTQFLGVYFVSSQEF---LANAYVLAVLLFLALLLQRTFLQASYYVAIET 383

  Fly   157 GMKMRIALSSLIYRKALRLSRT--ALGDTTVGQVVNLLSNDVGRFDLVLINVHYLWIAPLELIAV 219
            |:.:|.|:.:.||.|.:.||.:  ::|:.|.||:.||::.|..:..........||..|:::|..
Human   384 GINLRGAIQTKIYNKIMHLSTSNLSMGEMTAGQICNLVAIDTNQLMWFFFLCPNLWAMPVQIIVG 448

  Fly   220 TYLMYLEIGISSMFGVAIMLLFLPFQSYLGKRTSVLRLRTALRTDERVRMMNEIISGIQVIKMYA 284
            ..|:|..:|:|::.|.|:::|..|.|.::..:.|..:..|...::||::..||::.||:::|:||
Human   449 VILLYYILGVSALIGAAVIILLAPVQYFVATKLSQAQRSTLEYSNERLKQTNEMLRGIKLLKLYA 513

  Fly   285 WEKPFGKVVEMTRFNEMLCIKQVNYIRGILISFAMFLS-RIFTSSSL-IAFVLL---GNI----- 339
            ||..|...||.||..||..::          :||::.| .||.:::: ||.||:   |::
Human   514 WENIFRTRVETTRRKEMTSLR----------AFAIYTSISIFMNTAIPIAAVLITFVGHVSFFKE 568

  Fly   340 --LNAEKAFFVTAYYNILRRSVTMFF--PQGISEFAELLVSVRRLEAFM------------HRPE 388
              .:...||...:.::||   ||..|  ...:....:.||||::|..|:            |.|
Human   569 ADFSPSVAFASLSLFHIL---VTPLFLLSSVVRSTVKALVSVQKLSEFLSSAEIREEQCAPHEP- 629

  Fly   389 TKVRDKSKVKNANQ-----KAESPNGDSPKGNGIP---------------------ENLIEFSQF 427
            |.....||.:...:     .:..|:|.||..:..|                     ::|:..:..
Human   630 TPQGPASKYQAVEEGLPSLHSSQPSGSSPPNHPQPLRVVNRKRPAREDCRGLTGPLQSLVPSADG 694

  Fly   428 QA------------RWESHSLEPTLEDINLQLGRRKLVAVIGPVGAGKSSLIQAILGELPGESGT 480
            .|            .|....: |||.:|.:::.|.:|..::|.||.|||||:.|.|||:...||.
Human   695 DADNCCVQIMGGYFTWTPDGI-PTLSNITIRIPRGQLTMIVGQVGCGKSSLLLAALGEMQKVSGA 758

  Fly   481 ---------------------------LRINGSYSYAAQEPWLFTGTVRQNILFGLDWDKHRYRT 518
                                       :|..|..:||:|:|||...||.:||:|...::|.||:.
Human   759 VFWSSSLPDSEIGEDPSPERETATDLDIRKRGPVAYASQKPWLLNATVEENIIFESPFNKQRYKM 823

  Fly   519 VVKKCALERDFELLPFGDKTIVGERGASLSGGQKARISLARAVYRRADIYLLDDPLSAVDTHVGR 583
            |::.|:|:.|.::||.||:|.:||||.:|||||:.|||:|||:|:.|::..||||.||:|.|:..
Human   824 VIEACSLQPDIDILPHGDQTQIGERGINLSGGQRQRISVARALYQHANVVFLDDPFSALDIHLSD 888

  Fly   584 HLFDQCMRGYLRSE--LVILVTHQLQFLEQADLIVIMDKGRISAMGTYSSMKRSGLD-FAQLLTA 645
            ||....:...||.:  .|:||||:||:|..||.|:.|..|.|...||....:||... |....|.
Human   889 HLMQAGILELLRDDKRTVVLVTHKLQYLPHADWIIAMKDGTIQREGTLKDFQRSECQLFEHWKTL 953

  Fly   646 PNKDAEDLDEIDGAGGDGLDLLNVPSLSRRGSKNSKPSTRNNSFTSLSSMAESMAQEASLQMQET 710
            .|:..::|::              .:::.| .....|...:.:.:|...:.:...:|.. :..|:
Human   954 MNRQDQELEK--------------ETVTER-KATEPPQGLSRAMSSRDGLLQDEEEEEE-EAAES 1002

  Fly   711 RVEGKIGLGLYK----------EYLTSGSSWFMIFFMVFLCLATQILCSAADYFLSYWVD----- 760
            ..:..:...|::          :||:| :...::..:||..|...::..|.||:|:.|.|
Human  1003 EEDDNLSSMLHQRAEIPWRACAKYLSS-AGILLLSLLVFSQLLKHMVLVAIDYWLAKWTDSALTL 1066

  Fly   761 ----KNVDGQTDINTDPQDMY--YFAALNVAVVVFTIVRTMLFYKMAMRSSTQLHNAMYQGITRA 819
                :|.....:...| |.:|  .|..|....:|..:|.::......::.:.:||.::...|..|
Human  1067 TPAARNCSLSQECTLD-QTVYAMVFTVLCSLGIVLCLVTSVTVEWTGLKVAKRLHRSLLNRIILA 1130

  Fly   820 AMYFFNTNPSGRILNRFSKDLGQLDEVLPSVMLDVVQLFLTLLGIIVVICITNPYYLILTLALAI 884
            .|.||.|.|.|.||||||.|...:|:.:||.:..:.:..|..:..:.||....|.:|:..|.|||
Human  1131 PMRFFETTPLGSILNRFSSDCNTIDQHIPSTLECLSRSTLLCVSALAVISYVTPVFLVALLPLAI 1195

  Fly   885 IFYYIREFYLKTSRDVKRLEAVARSPIYSHLSATITGLPTIRALGAQ---KELIAEFDNLQDLHS 946
            :.|:|::::...|||:::|:...:.|:.||.:.|:.||.||||...:   ::.:.|:.:..::.|
Human  1196 VCYFIQKYFRVASRDLQQLDDTTQLPLLSHFAETVEGLTTIRAFRYEARFQQKLLEYTDSNNIAS 1260

  Fly   947 SGYYTFL-ATNRAFGY---YLDCFCTLYIVIIILNYFINPPQSPGEVGLAITQAMGMTGMVQWAM 1007
                .|| |.||....   |:.....|...:..::..::...|.|.|||.:|.|:.::..:.|.:
Human  1261 ----LFLTAANRWLEVRMEYIGACVVLIAAVTSISNSLHRELSAGLVGLGLTYALMVSNYLNWMV 1321

  Fly  1008 RQSAELENTMTAVERVVEYDEIEPEGEFDSREG-KKPS---PSWPEKGEIIAEDLCLRYFPDPQA 1068
            |..|::|..:.||:|:  :..::.|.|  |.|| ..||   .:||::|:|..::|.:||  |...
Human  1322 RNLADMELQLGAVKRI--HGLLKTEAE--SYEGLLAPSLIPKNWPDQGKIQIQNLSVRY--DSSL 1380

  Fly  1069 KYVLKALNFRIRPCEKVGIVGRTGAGKSSLINALFRL-SYNEGIITIDERDTADMGLFDLRSKIS 1132
            |.|||.:|..|.|.:|:||.||||:||||...|.||: ...||.|.||..|.|.:.|..|||::|
Human  1381 KPVLKHVNALIAPGQKIGICGRTGSGKSSFSLAFFRMVDTFEGHIIIDGIDIAKLPLHTLRSRLS 1445

  Fly  1133 IIPQEPVLFSGSMRYNLDPFEEYNDAKLWDALEEVKLKPLISELPNGLQSKISEGGSNFSVGQRQ 1197
            ||.|:||||||::|:||||..:.:|:.||:|||..:||.::..||.||.:.|:|||.|||.||||
Human  1446 IILQDPVLFSGTIRFNLDPERKCSDSTLWEALEIAQLKLVVKALPGGLDAIITEGGENFSQGQRQ 1510

  Fly  1198 LVCLARAILRENRVLVMDEATANVDPQTDALIQATIRSKFRDCTVLTIAHRLNTIMDSDRVLVMD 1262
            |.|||||.:|:..:.:||||||::|..|:.::|..:.:.|.|.||:|||||::||:.:|.|:|:.
Human  1511 LFCLARAFVRKTSIFIMDEATASIDMATENILQKVVMTAFADRTVVTIAHRVHTILSADLVIVLK 1575

  Fly  1263 AGHLVEFGSPYELLTSSESKIFHGMV 1288
            .|.::||..|.:||:..:| :|...|
Human  1576 RGAILEFDKPEKLLSRKDS-VFASFV 1600

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mrp4	NP_650086.2	CFTR_protein	12..1277	CDD:273530	437/1442 (30%)
		ABC_membrane	93..359	CDD:294371	75/300 (25%)
		ABCC_MRP_domain1	422..622	CDD:213217	88/240 (37%)
		ABC_membrane	735..978	CDD:294371	71/260 (27%)
		ABCC_MRP_domain2	1051..1272	CDD:213211	109/221 (49%)
ABCC8	XP_016873686.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151573
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.650