Protein Alignment Mrp4 and Abcb10

DIOPT Version :9

• Sequence 1: NP_650086.2
• Gene: Mrp4 / 41387
• FlyBaseID: FBgn0263316
• Length: 1316
• Species: Drosophila melanogaster
• Sequence 2: NP_062425.1
• Gene: Abcb10 / 56199
• MGIID: 1860508
• Length: 715
• Species: Mus musculus
• Alignment Length: 599
• Identity: 147/599 - (24%)
• Similarity: 248/599 - (41%)
• Gaps: 117/599 - (19%)

  Fly   739 FLCLATQILCSAADYFLSYWVDKNVDGQTDINTDPQDMYYFAALNVAVVVFTI---------VRT 794
            ||.::: ::..:|.:||...:|.       |.|:|.:.|..:...:..|:..:         :|.
Mouse   142 FLAVSS-VITMSAPFFLGRIIDV-------IYTNPSEGYGDSLTRLCAVLTCVFLCGAAANGIRV 198

  Fly   795 MLFYKMAMRSSTQLHNAMYQGITRAAMYFFNTNPSGRILNRFSKDLGQLDEVLPSVMLD------ 853
            .|..........:|..:::..|.|..:.||:...:|.::||.|.|...|...:...:.|
Mouse   199 YLMQSSGQSIVNRLRTSLFSSILRQEVAFFDKTRTGELINRLSSDTALLGRSVTENLSDGLRAGA 263

  Fly   854 -----VVQLFLTLLGIIV-VICITNPYYLILTLALAIIF-YYIREFYLKTSRDVKRLEAVARSPI 911
                 |..:|.....:.. |:.:..|..:     ||:|: .|:|:....|...:.....:|..
Mouse   264 QASVGVGMMFFVSPSLATFVLSVVPPISV-----LAVIYGRYLRKLSKATQDSLAEATQLAEE-- 321

  Fly   912 YSHLSATITGLPTIRALG-------------------AQKELIAEFDNLQDLHSSGYY--TFLAT 955
                  .|..:.||||.|                   ||||.:|.         :|::  ..|:.
Mouse   322 ------RIGNIRTIRAFGKEMTEVEKYTGRVDQLLQLAQKEALAR---------AGFFGAAGLSG 371

  Fly   956 NRAFGYYLDCFCTLYIVIIILNYFINPPQSPGE----------VGLAITQAMGMTGMVQWAMRQS 1010
            |      |.....||...:::.   :...:.||          |||:|.   |::...
Mouse   372 N------LIVLSVLYKGGLLMG---SAHMTVGELSSFLMYAFWVGLSIG---GLSSFY------- 417

  Fly  1011 AELENTMTAVERVVEYDEIEPEGEFDSREGKKPSPSWPEK---GEIIAEDLCLRYFPDPQAKYVL 1072
            :||...:.|..|:.|..|.:|...|:  ||.    ...||   |.:...::...|...|:.. |.
Mouse   418 SELMKGLGAGGRLWELLERQPRLPFN--EGM----VLDEKTFQGALEFRNVHFTYPARPEVS-VF 475

  Fly  1073 KALNFRIRPCEKVGIVGRTGAGKSSLINALFRL-SYNEGIITIDERDTADMGLFDLRSKISIIPQ 1136
            :..:..|.......:||.:|:|||::::.|.|| ..|.|.:::|..|...:....|||||..:.|
Mouse   476 QDFSLSIPSGSVTALVGPSGSGKSTVVSLLLRLYDPNSGTVSLDGHDIRQLNPVWLRSKIGTVSQ 540

  Fly  1137 EPVLFSGS----MRYNLDPFEEYNDAKLWDALEEVKLKPLISELPNGLQSKISEGGSNFSVGQRQ 1197
            ||||||.|    :.|..|........::..|.|.......|...|.|..:.:.|.|...|.||:|
Mouse   541 EPVLFSCSVAENIAYGADNLSSVTAQQVERAAEVANAAEFIRSFPQGFDTVVGEKGILLSGGQKQ 605

  Fly  1198 LVCLARAILRENRVLVMDEATANVDPQTDALIQATIRSKFRDCTVLTIAHRLNTIMDSDRVLVMD 1262
            .:.:|||:|:..::|::||||:.:|.:.:.|:|..:.......|||.|||||:||.:::.|.|:|
Mouse   606 RIAIARALLKNPKILLLDEATSALDAENEHLVQEALDRLMEGRTVLIIAHRLSTIKNANFVAVLD 670

  Fly  1263 AGHLVEFGSPYELL 1276
            .|.:.|.|:..|||
Mouse   671 HGKICEHGTHEELL 684

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mrp4	NP_650086.2	CFTR_protein	12..1277	CDD:273530	147/599 (25%)
		ABC_membrane	93..359	CDD:294371
		ABCC_MRP_domain1	422..622	CDD:213217
		ABC_membrane	735..978	CDD:294371	53/281 (19%)
		ABCC_MRP_domain2	1051..1272	CDD:213211	72/225 (32%)
Abcb10	NP_062425.1	3a01208	8..694	CDD:273363	147/599 (25%)
		ABC_membrane	142..403	CDD:279056	55/299 (18%)
		ABC_MTABC3_MDL1_MDL2	458..698	CDD:213216	74/228 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000