DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mrp4 and abcc9

DIOPT Version :9

Sequence 1:NP_650086.2 Gene:Mrp4 / 41387 FlyBaseID:FBgn0263316 Length:1316 Species:Drosophila melanogaster
Sequence 2:XP_005164758.1 Gene:abcc9 / 561160 ZFINID:ZDB-GENE-050517-23 Length:1583 Species:Danio rerio


Alignment Length:1395 Identity:436/1395 - (31%)
Similarity:700/1395 - (50%) Gaps:161/1395 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly    20 LSSLMFCFALPVLFKGRKKTLEQKDL------YRALKEHKSDSLGDRLCAAWDEQVAKNE----T 74
            ||...:.:..|::....|:.:|.|.:      .|||..:.      ||..:::||....|    :
Zfish   225 LSKATYWWMNPLIIGAHKRPIELKKIGKLPIAMRALTNYL------RLKDSYEEQRQNTEDPEKS 283

  Fly    75 PRLGRALTKVFGFHLFITGVFLLAQEFLTKVTQPICLIGVMAYFAGN-DPDR------------- 125
            |.:.:::.:.||..:.::..|....:.| ....|:|:.|::.:...: :.||             
Zfish   284 PSIWKSMYRAFGGSILLSSTFRYMADLL-GFAGPLCISGIVEHLHNSTEIDRTNKTGNMTFGVYF 347

  Fly   126 --SKAQLWAAGLIAGSVFSVCIGHPYMLG-----LLHLGMKMRIALSSLIYRKALRLSRT--ALG 181
              |...|....::|..:|...:.....|.     .:..|:.:|.||.::||.|.||||.:  ::|
Zfish   348 MSSTELLQNTSVLAVLLFLALVLQRTFLQASYYVTIETGINLRGALLAMIYNKILRLSTSNMSMG 412

  Fly   182 DTTVGQVVNLLSNDVGRFDLVLINVHYLWIAPLELIAVTYLMYLEIGISSMFGVAIMLLFLPFQS 246
            :.|:||:.||::.:..:....|.....||..|:::|....|:|..:|.|::.|..::||..|.|.
Zfish   413 EMTLGQINNLVAIETNQLMWFLFLCPNLWAMPVQIIMGVILLYYLLGNSALIGAGVILLLAPVQY 477

  Fly   247 YLGKRTSVLRLRTALRTDERVRMMNEIISGIQVIKMYAWEKPFGKVVEMTRFNEMLCIKQVNYIR 311
            .:..:.:.::..|...:.:|::...||:.||:::|:||||..|...||.||..|:..:|      
Zfish   478 LIATKLADIQKSTLDYSTDRLKKTTEILKGIKLLKLYAWENIFCDRVEETRGKELTSLK------ 536

  Fly   312 GILISFAMFLS-RIFTSSSL-IAFVLLGNI---------LNAEKAFFVTAYYNILRRSVT-MFFP 364
                :||:..| .||.:::: ||.||...:         |:..|||...|.::||   || :|..
Zfish   537 ----TFALHTSMSIFMNAAIPIAAVLATFVTHAYIEEDRLSPAKAFASLALFHIL---VTPLFLL 594

  Fly   365 QGISEFA-ELLVSVRRLEAFMHRPET--------------------KVRDKSKVKNANQKAESPN 408
            ..:..|| :.||||::|..|:...|.                    |.:..:|..|...:....|
Zfish   595 STVVRFAVKALVSVQKLSEFLQSDEIGDDSWRNGDMCMSLEVGKKYKYQGDTKAINRKGRYRMDN 659

  Fly   409 GDSPKGNGIPENLIEFSQFQAR-----WESHSLEPTLEDINLQLGRRKLVAVIGPVGAGKSSLIQ 468
            .:.|....:..:..|....|..     |.|:.  .||.|||:::...:|..::|.||.|||||:.
Zfish   660 YEQPVRRQLRPSETEDVAVQVNDGFFTWGSNL--STLSDINIRIPTGQLTMIVGQVGCGKSSLLL 722

  Fly   469 AILGELPGESGTL--------------RING---------------SYSYAAQEPWLFTGTVRQN 504
            |:|||:...||.:              .|:|               |.:||.|:.||...||.:|
Zfish   723 AMLGEMQTISGKVYWSKLPDCEILFDGNISGHDMELSHEERSKNRYSVAYATQKSWLLNATVEEN 787

  Fly   505 ILFGLDWDKHRYRTVVKKCALERDFELLPFGDKTIVGERGASLSGGQKARISLARAVYRRADIYL 569
            |.||..::|.||:.|:..|:|:.|.:||||||:|.:||||.:|||||:.||.:|||:|:..:|..
Zfish   788 ITFGSPFNKQRYKAVIDACSLQPDIDLLPFGDQTEIGERGINLSGGQRQRICVARALYQNTNIVF 852

  Fly   570 LDDPLSAVDTHVGRHLFDQCMRGYLRSE--LVILVTHQLQFLEQADLIVIMDKGRISAMGTYSSM 632
            ||||.||:|.|:..||..:.:..:|:.:  .|:||||:||:|..||.|:.|..|.:...||...:
Zfish   853 LDDPFSALDIHLSDHLMQEGILKFLQDDKRTVVLVTHKLQYLIHADWIIAMKDGSVLREGTLKDI 917

  Fly   633 KRSGLD-FAQLLTAPNKDAEDLDEIDGAGGDGLDLLNVPSLSRRGSKNSKPSTRNNSFTSLSSMA 696
            :...:: :....|..|:..::|::       ..||.:..:|.|:..:.:..|....:........
Zfish   918 QTHDVELYEHWKTLMNRQDQELEK-------DTDLESQTTLERKTLRRAFYSREAKNHVDDEDEE 975

  Fly   697 ESMAQEASLQMQETRV-EGKIGLGLYKEYLTSGSSWFMIFFMVFLCLATQILCSAADYFLSYWVD 760
            |.:.:|....|..|.. ..||...:...||:|| .:.|:|.||...||...:..|.||:|:.|..
Zfish   976 EEVEEEDDDNMSTTTSRRSKIPWKMCCCYLSSG-GFLMVFLMVSSKLAKHSVMVAIDYWLAAWTS 1039

  Fly   761 KNVDGQTDINTD------------PQDMYY---FAALNVAVVVFTIVRTMLFYKMAMRSSTQLHN 810
            .|...|:.:|:.            .:...|   |..|..|.:...::.::....:.:.::|.||:
Zfish  1040 SNPHNQSFVNSSFNHTLNDDATQIAEHRSYVPVFIILCAAAIALCLITSLTVEFLGVAAATNLHH 1104

  Fly   811 AMYQGITRAAMYFFNTNPSGRILNRFSKDLGQLDEVLPSVMLDVVQLFLTLLGIIVVICITNPYY 875
            .:...|..|.:.||:..|.|:||||||.|...:|:.:|..:..:.:..|..|..|.||....|.:
Zfish  1105 NLLNKIIHAPIRFFDVTPLGQILNRFSADTNIIDQHIPPTLESLTRSTLLCLSAIGVIAFVTPAF 1169

  Fly   876 LILTLALAIIFYYIREFYLKTSRDVKRLEAVARSPIYSHLSATITGLPTIRALGAQKELIAEFDN 940
            ||..:.||:.||:|::::...|:|::.|:...:.|:..|.|.|..||.||||...:.........
Zfish  1170 LIALVPLAVAFYFIQKYFRVASKDLQELDDSTQLPLLCHFSETAEGLTTIRAFRHEARFKQRMLE 1234

  Fly   941 LQDLHSSGYYTFLATNRAFGYYLDCFCTLYIVIIILNYFINP--PQSP-GEVGLAITQAMGMTGM 1002
            |.|.:::.|....|.||    :|:........:|:|...:..  ..|| |.|||.:|.|:.:|..
Zfish  1235 LTDTNNTAYLFLSAANR----WLEVRTDYLGAVIVLTAAVAAIWSTSPSGLVGLGLTYALTLTNY 1295

  Fly  1003 VQWAMRQSAELENTMTAVERVVEYDEIEPEGEFDSREGKKPSPSWPEKGEIIAEDLCLRYFPDPQ 1067
            :.|.:|..|:||..|.||::|..:...|.|....|.:..:....||:.|||...|||:||  |..
Zfish  1296 LNWVVRNLADLEVQMAAVKKVNSFLSTESENYEGSMDVSQVPEDWPQHGEITIHDLCVRY--DSM 1358

  Fly  1068 AKYVLKALNFRIRPCEKVGIVGRTGAGKSSLINALFRL-SYNEGIITIDERDTADMGLFDLRSKI 1131
            .|.|||.:|..|.|.:||||.||||:|||||..|.|.: ...||.|.||..|...:.|..|||::
Zfish  1359 LKPVLKHVNAHINPGQKVGICGRTGSGKSSLSLAFFNMVDVFEGKIVIDGIDICKLPLQTLRSRL 1423

  Fly  1132 SIIPQEPVLFSGSMRYNLDPFEEYNDAKLWDALEEVKLKPLISELPNGLQSKISEGGSNFSVGQR 1196
            |||.|:|||||||:|.||||.....|.:||:|||..:||.::..||.||.:.::|||.|||||||
Zfish  1424 SIILQDPVLFSGSIRLNLDPERTCTDDRLWEALEIAQLKNMVKALPGGLDAVVTEGGENFSVGQR 1488

  Fly  1197 QLVCLARAILRENRVLVMDEATANVDPQTDALIQATIRSKFRDCTVLTIAHRLNTIMDSDRVLVM 1261
            ||.|||||.:|::.:|:||||||::|..|:.::|..:.:.|.|.||:||||.:::|:::::|||.
Zfish  1489 QLFCLARAFVRKSSILIMDEATASIDMATENILQKVVMTAFADRTVVTIAHLVSSILEAEQVLVF 1553

  Fly  1262 DAGHLVEFGSPYELLTSSESKIFHGMVMET 1291
            .:|.|||..|...||...:|  ..|:::.|
Zfish  1554 SSGILVENDSAINLLAQEDS--LFGILVRT 1581

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Mrp4NP_650086.2 CFTR_protein 12..1277 CDD:273530 432/1379 (31%)
ABC_membrane 93..359 CDD:294371 77/299 (26%)
ABCC_MRP_domain1 422..622 CDD:213217 91/235 (39%)
ABC_membrane 735..978 CDD:294371 70/257 (27%)
ABCC_MRP_domain2 1051..1272 CDD:213211 113/221 (51%)
abcc9XP_005164758.1 CFTR_protein 223..1575 CDD:273530 434/1387 (31%)
ABC_membrane 304..591 CDD:294371 79/300 (26%)
ABCC_SUR1_N 678..907 CDD:213257 90/230 (39%)
ABC_membrane 1045..1300 CDD:294371 69/258 (27%)
ABCC_SUR2 1269..1583 CDD:213255 142/317 (45%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C170586003
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0054
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D138195at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100026
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
54.650

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