DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mrp4 and abcc13

DIOPT Version :9

Sequence 1:	NP_650086.2	Gene:	Mrp4 / 41387	FlyBaseID:	FBgn0263316	Length:	1316	Species:	Drosophila melanogaster
Sequence 2:	XP_017209479.1	Gene:	abcc13 / 559093	ZFINID:	ZDB-GENE-050517-26	Length:	1020	Species:	Danio rerio

Alignment Length:	1321	Identity:	275/1321 - (20%)
Similarity:	489/1321 - (37%)	Gaps:	391/1321 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 MFCF-ALPVLFKGRKKTLEQK---DLYRALKEHKSDSLGDRLCAAWDEQVAKNE----------- 73
            ::|| ..|||:..|...:..:   .|:..||.:..||: ..||:.:|.:..|.:
Zfish    15 LYCFQTSPVLYNMRMVVMGHRGPLQLFDLLKLYNEDSV-HTLCSVFDHEWEKQQNNYKERSDLED 78

  Fly    74 ---------TPRLGRALTKVF----GFHLFITGVFLL-AQEFLTKVTQPICLIGVMAYFAGNDPD 124
                     |.:.....:.::    .||..:..:.|| ....|..:..||.:..|:.:     .:
Zfish    79 DSGRKSLLVTSKTNAGYSLLYTLWKTFHPSLIKIVLLRLSSDLFSILVPITIRWVILF-----SE 138

  Fly   125 RSKAQLWAAGLIAGSVF-SVCIG----HPYMLGLLHLGMKMRI-------ALSSLIYR--KALRL 175
            |.....|.....|..|| ::|.|    |       |...:.||       .||..:||  |.|.|
Zfish   139 RQAMFGWTGYTYALVVFGALCCGAFSQH-------HFEKRSRIITANAHAILSGTVYRKIKTLSL 196

  Fly   176 SRTALGDTTVGQVVNLLSNDVGRFDLVLINVHYLWIAPLELIAVTYLMYLEIGISSMFGVAIMLL 240
            |.::...:......::| .:..|...:::.:..:|.:||.:.....|::.::|.|.:.||.::|:
Zfish   197 SHSSRWHSDTSHREDML-GEAERVAELVVTLACIWSSPLRVTLYLGLLWAKLGPSVLVGVTLLLV 260

  Fly   241 FLPFQSYLGKRTSVLRLRTALRTDERVRMMNEIISGIQVIKMYAWEKPFGKVVEMTRFNEMLCIK 305
            .:|.:|.:.::...||....:..::..:::.|::...|.:|:..||..|.:.|..:|..|:..::
Zfish   261 LIPVKSAVERKAKQLRRTHRVIREKSEQLIKEMLHKYQALKLLTWESWFFQRVTESRTRELEMLR 325

  Fly   306 QVNYIRGILISFAMF----LSRIFTSSSLIAFVLL--GNILNAEKAFFVTAYYNILRRSVTMFFP 364
                |:|.|.:|:|.    :..:...|||.||||:  ||:|.:.:.|....::.:||
Zfish   326 ----IQGFLTAFSMLDSICMPFLVIFSSLGAFVLVDDGNVLTSSQIFTSVCFFRLLR-------- 378

  Fly   365 QGISEFAELLVSVRRLEAFMHRPETKVRDKSKVKNANQKAESPNGDSPKGNGIPENLIEFSQFQA 429

Zfish   379 ----------------------------------------------------------------- 378

  Fly   430 RWESHSLEPTLEDINLQLGRRKLVAVIGPVGAGKSSLIQAILGELPGESGTLRINGSYSYAAQEP 494
                   .|.||.:                                         |.:|...|..
Zfish   379 -------PPLLEFL-----------------------------------------GLFSVLKQAQ 395

  Fly   495 WLFTGTVRQNILFGLDWDKHRYRTVVKKCALERDFELLPFGDKTIVGERGASLSGGQKARISLAR 559
            ..|                         |.||:.|.....|....: .:||:
Zfish   396 QSF-------------------------CYLEKIFLTEDLGTSQFL-TKGAT------------- 421

  Fly   560 AVYRRADIYLLDDPLSAVDTHVGRHLFDQCMRGYLRSELVILVTHQLQFLEQADLIVIMDKGRIS 624
                        :..||..|   :...|:|..                  :|.|
Zfish   422 ------------EESSADST---QQPCDECQE------------------KQND----------- 442

  Fly   625 AMGTYSSMKRSGLDFAQLLTAPNKDAEDLDEIDGA-----GGDGLDLLNVPSLSRRGSKNSKPST 684
                 |..||....|.             :|...|     |..|...::|.||
Zfish   443 -----SDEKRDHYHFR-------------NEFREACWLYLGAFGWHWVSVCSL------------ 477

  Fly   685 RNNSFTSLSSMAESMAQEASLQMQETRVEGKIGLGLYKEYLTSGSSWFMIFFMVFLCLATQILCS 749
                 ..||..|.|:||:..|.|.....:...||..:||...|..|.:.:..:    |...::|.
Zfish   478 -----VYLSVCAVSLAQDGVLCMWTGEAKEVQGLDGWKELRNSRLSAYALLGL----LQAFLVCC 533

  Fly   750 AADYFLSYWVDKNVDGQTDINTDPQDMYYFAALNVAVVVFTIVRTMLFYKMAMRSSTQLHNAMYQ 814
            || |.|:..                                          ::::|..||..:..
Zfish   534 AA-YCLTCG------------------------------------------SLKASRTLHTELLS 555

  Fly   815 GITRAAMYFFNTNPSGRILNRFSKDLGQLDEVLPSVMLDVVQLFLTLLGIIVVICITNPYYLILT 879
            .:....::....| :.:::...::|:..:||.||..:..:::..|.:|..|.:|....|.:.:..
Zfish   556 DVLHLPVHSQKMN-TRKLMQALTQDMQVIDEELPKHLHSILKSLLDVLSTITLISFIIPVFSLAV 619

  Fly   880 LALAIIFYYIREFYLKTSRDVKRLEAVARSPIYSHLS---------ATITGLPTIRALGAQKELI 935
            ..:.|:..:|:.....|...::.:||   :|..|..|         |:::| |..||:..:..|.
Zfish   620 CPMIILLLHIQSRISSTHMQIRNMEA---NPAVSLTSLARVTQCAEASLSG-PEHRAVCLKHCLQ 680

  Fly   936 AEFDNLQDLHSSGYYTFLATNRAFGYYLDCFCTLYIVIIILNYFINPPQSPGEVGLAITQAMGMT 1000
            |...||     ...|..:.|......:.|....:.::::.|......|:| |.|.|.:..:..:.
Zfish   681 AFTQNL-----LLKYNTINTESWVVLWFDGVAGIVLLLVSLILLQTQPES-GLVALTLICSFNIK 739

  Fly  1001 GMVQWAMRQSAELENTMTAVERVVEYDEIEPEGEFDSREGKKPSPSWPEKGEIIAEDLCLRYFPD 1065
            ..:.:..:.::.:...|.:::.:  :|..:.|.|.:.....:|...||:.||:...:.      :
Zfish   740 EALHYCPQAASVITTDMLSLQNL--FDSAKAEKEAEWTVNYRPPYDWPQHGEVKFRNY------E 796

  Fly  1066 PQAKY----VLKALNFRIRPCEKVGIVGRTGAGKSSLINALFR-LSYNEGIITIDERDTADMGLF 1125
            .:|..    .|:.::..|...||:|:|.|.......|||:||| :....|.:.||..:.:.|||.
Zfish   797 SEASSDGTPALRGVHLTILKGEKIGVVSRQKTDTDVLINSLFRSVEARSGALLIDNINISRMGLH 861

  Fly  1126 DLRSKISIIPQEPVLFSGSMRYNLDPFEEYNDAKLWDALEEVKLKPLISELPNGLQSKISEGGSN 1190
            |||.::.||.|.||||||.:|.|||||.|::||::|.|||...||..:.::|..|...:......
Zfish   862 DLRGRLQIISQVPVLFSGPLRANLDPFAEHSDAQVWLALELCHLKESVQQMPAQLLHPVQRTALA 926

  Fly  1191 FSVGQRQLVCLARAILRENRVLVMDEATANVDPQTDALIQATIRSKFRDCTVLTIAHRLNTIMDS 1255
            ||.|||:|:|||||:|...|:|:::|...:|||:|:.|:|..|.::|:|||||.::....:::.:
Zfish   927 FSFGQRRLLCLARALLARVRILLVEEPLHHVDPETEDLLQQVIHAEFKDCTVLFLSQNPLSVLHT 991

  Fly  1256 DRVLVMDAGHLVEFGSPYELL 1276
            |||||:|.|..|:|.:|..||
Zfish   992 DRVLVLDKGQAVKFDAPSTLL 1012

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mrp4	NP_650086.2	CFTR_protein	12..1277	CDD:273530	275/1321 (21%)
		ABC_membrane	93..359	CDD:294371	67/286 (23%)
		ABCC_MRP_domain1	422..622	CDD:213217	21/199 (11%)
		ABC_membrane	735..978	CDD:294371	41/251 (16%)
		ABCC_MRP_domain2	1051..1272	CDD:213211	88/225 (39%)
abcc13	XP_017209479.1	SunT	29..>409	CDD:331423	90/543 (17%)
abcc13	XP_017209479.1	SunT	<461..1018	CDD:331423	163/635 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586122
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.840