DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Mrp4 and abcc10

DIOPT Version :9

Sequence 1:NP_650086.2 Gene:Mrp4 / 41387 FlyBaseID:FBgn0263316 Length:1316 Species:Drosophila melanogaster
Sequence 2:XP_005155817.1 Gene:abcc10 / 556709 ZFINID:ZDB-GENE-050517-24 Length:1548 Species:Danio rerio


Alignment Length:1377 Identity:444/1377 - (32%)
Similarity:698/1377 - (50%) Gaps:171/1377 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly    17 SSPLSSLMFCFALPVLFKGRKKTL-EQKDLYRALKEHKSDSLGDRLCAAWD-------------- 66
            ||.||.|::.:..|:|.:|::..| ...|::......::.|:..|....|:              
Zfish   231 SSLLSRLLYLWLNPLLNRGKRGELGRPSDVFELPSRLRTKSVTRRFYQCWEKCLHSRALERPERP 295

  Fly    67 ------------------EQVAKNETP---RLGRALTKVFGFHLFITGVFLLAQEFLTKVTQPIC 110
                              |::.:.|..   :|.:.|.|.||...::.|...|....|. ...|:.
Zfish   296 DRRPRGNLQDNSWSEAQPERICEGEAEHEVKLLQVLHKAFGLRYYLLGGLKLVASMLA-FAGPLL 359

  Fly   111 LIGVMAYFAGNDPDRSKAQLWAAGLIAGSVFSVCIGHPYMLGLLHLGMKMRIALSSLIYRKALRL 175
            |.|::.:........||....|.||.|.:..:..:.:.::..:..:.::.|.|:.|.||.|||::
Zfish   360 LGGLVGFMETEGAPLSKGVWCAVGLFASTFLAALLKNIFVYEVSKVALEARAAVISTIYCKALKV 424

  Fly   176 SRTALGDTTVGQVVNLLSNDVGRFDLVLINVHYLWIAPLELIAVTYLMYLEIGISSMFGVAIMLL 240
            :..:|....:|:|||.:|.|..|......:.|.:|..|.:.:...||:||::|::.:.||.:.:|
Zfish   425 NAPSLARFNMGEVVNFMSTDTDRVVNFFNSFHEVWSLPFQFVLALYLLYLQVGVAFLGGVGVAVL 489

  Fly   241 FLPFQSYLGKRTSVLRLRTALRTDERVRMMNEIISGIQVIKMYAWEKPFGKVVEMTRFNEMLCIK 305
            .:|....|..|............|.||::|.||:.||:|:|.|.||:.|.:.:|..|..|:..:|
Zfish   490 LVPLNKVLASRILENNKHMLQHKDGRVKLMTEILFGIRVLKYYNWEEHFTQKIEEARKKELHHLK 554

  Fly   306 QVNYIRGILISFAMFLSRIFTSSSLIAFVLLGNILNAEKAFFVTAYYNILRRSVTMFFPQGISEF 370
            .:.|:..:.:.....|..:.:..:.|.:|||||.|.|.|.|...|...:|...:.. ||..::..
Zfish   555 LLKYLDAVCVYTWAALPVVISILTFITYVLLGNNLTAAKVFSTLALVGMLILPLNA-FPWVLNGT 618

  Fly   371 AELLVSVRRLEAFMH-------------RPETKVRDKSKVKNANQKAESPNGDSPKGNGIPENLI 422
            .|..||:.|::.|:.             .||........|:.:....:|...||.   .||:::.
Zfish   619 LEAKVSLDRIQRFLAVQDQDLSVYYSQVCPEDPPSAVQMVQASFSWKQSEEADSV---SIPDDIT 680

  Fly   423 EFSQFQARWESHSLEPTLEDINLQLGRRKLVAVIGPVGAGKSSLIQAILGELPGESGTLRING-- 485
            |.......:..|:|     ::|:::|  .||.|:|.||.|||||:.||.|||....|.:.:.|  
Zfish   681 EEGSPPRSFYLHAL-----NLNVKMG--SLVVVVGKVGCGKSSLLAAITGELTRCGGEVFVQGRE 738

  Fly   486 -SYSYAAQEPWLFTGTVRQNILFGLDWDKHRYRTVVKKCALERDFELLPFGDKTIVGERGASLSG 549
             .:..|.||||:...||:.|||||.|:|...|::|::.|||..|..:||.||:|.|||.|.:|||
Zfish   739 QGFGLAVQEPWIQHATVQDNILFGRDYDNMFYQSVIQACALADDLNILPGGDQTEVGENGVTLSG 803

  Fly   550 GQKARISLARAVYRRADIYLLDDPLSAVDTHVGRHLFDQCMRGYLRSELVILVTHQLQFLEQADL 614
            |||:|::||||||...:||||||||:|||..|..||.::|:.|.|:.:..||.||:::|:::||:
Zfish   804 GQKSRLALARAVYMDKEIYLLDDPLAAVDADVAHHLMEKCILGILKDKTRILCTHRIEFVDKADV 868

  Fly   615 IVIMDKGRISAMGTYSSMKRSGLDFAQLLTAPNKDAEDLDEIDGAGGDGLDLLNVPSLSRRGSKN 679
            :|:||.|.|...|..|.:                               |.|:..|    :.|||
Zfish   869 VVLMDNGMIVKTGAPSEV-------------------------------LSLVKGP----KDSKN 898

  Fly   680 SKPSTRNNSFTSLSSMAESMAQEASLQM--QETRVEGKIGLGLYKEY--LTSGSSWFMIFFMVFL 740
            |..:...:|..|....|.....:|.|:|  :|.:..|.:...:|:.|  ...|.....:...:||
Zfish   899 SSNAKEKDSAGSEEMEASEPELKAELEMFGEEQKQMGTLSWAVYRSYWKAVGGCMAVAVLLALFL 963

  Fly   741 CLATQILCSAADYFLSYWVDKNVDGQTDI--------------------------------NTDP 773
            ..|::   :.:|::||:|:....|..|::                                |...
Zfish   964 MQASK---NVSDWWLSHWISHMKDNMTELVSVSATPLLMLSFLSPGRLVFNAPARGSESSGNMSS 1025

  Fly   774 QDMYY---FAALNVAVVVFTIVRTMLFYKMAMRSSTQLHNAMYQGITRAAMYFFNTNPSGRILNR 835
            :..:|   :.:|..|..|||..|..||...|:.::|.:|..:...:.:|.|.||:|.|.||||||
Zfish  1026 ELKFYMTVYGSLAAANTVFTAARAFLFAYGAICAATVVHKRLLSSVLKATMTFFDTTPLGRILNR 1090

  Fly   836 FSKDLGQLDEVLPSVMLDVVQLFLTLLGIIVVICITNPYYLILTLALAIIFYYIREFYLKTSRDV 900
            ||.|:..:|:.||.|:..::.....|||:::|:....|:.|:..:.|..::|..:.||..:||::
Zfish  1091 FSSDIYSVDDSLPFVLNILLANVFGLLGMLIVMSYGLPWVLLPLVPLGALYYQTQCFYRYSSREL 1155

  Fly   901 KRLEAVARSPIYSHLSATITGLPTIRALGAQKELIAEFDNLQDLHSSGYYTFLATNRAFGYYLDC 965
            |||.::..||:|||.|.|::||.|:|..|.....  |.:|.:.|..:....|  .:.|...:||.
Zfish  1156 KRLCSLTLSPVYSHFSETLSGLSTVRGSGHTTRF--EEENERRLEQNQRCLF--NSNAAMQWLDI 1216

  Fly   966 FCTLYIVIIILNYFI-----NPPQS--PGEVGLAITQAMGMTGMVQWAMRQSAELENTMTAVERV 1023
            ...:..|.::....:     :..:|  ||.|||:::.|:.:|.::...:...|:.|..:.::||.
Zfish  1217 RLQMIAVTVVTGISVIAVIQHQLKSIDPGLVGLSLSYALSITNLLSGLIFSYAQTEMQLVSIERT 1281

  Fly  1024 VEYDEIEPEGEFDSREGKKPS----PSWPEKGEIIAEDLCLRYFPD-PQAKYVLKALNFRIRPCE 1083
            .||....|:      |.::.|    ..|||:..:...|:.|.|.|. |.|   |..::..:.|.|
Zfish  1282 EEYSTSIPQ------EPQQASLEVLDRWPERARVEFVDVVLSYRPGLPNA---LDGVSVEVLPGE 1337

  Fly  1084 KVGIVGRTGAGKSSLINALFRL-SYNEGIITIDERDTADMGLFDLRSKISIIPQEPVLFSGSMRY 1147
            |:|||||||:|||||..||||: ..|:|.|.:|..|.:.:.|.|||||::||||:|.|||.|:|.
Zfish  1338 KIGIVGRTGSGKSSLFLALFRMVELNQGQILLDGVDISSVRLSDLRSKLAIIPQDPFLFSSSVRE 1402

  Fly  1148 NLDPFEEYNDAKLWDALEEVKLKPLISELPNGLQSKISEGGSNFSVGQRQLVCLARAILRENRVL 1212
            ||||...:.|.:|.:|||:..|..:: :...||.|::.|.|.:.|||||||:|||||:|.|..:|
Zfish  1403 NLDPHGRHPDYRLLEALEQCHLGNVV-QRNGGLDSEVGERGKSLSVGQRQLLCLARALLTEANIL 1466

  Fly  1213 VMDEATANVDPQTDALIQATIRSKFRDCTVLTIAHRLNTIMDSDRVLVMDAGHLVEFGSPYELLT 1277
            .:|||||:||.:||.|:|.|||.||:|.||||||||||||||||:||||.||.:|||.||..|..
Zfish  1467 CIDEATASVDQKTDMLLQKTIREKFKDKTVLTIAHRLNTIMDSDKVLVMHAGKVVEFDSPATLCQ 1531

  Fly  1278 SSES---KIFHG 1286
            ..:|   |:..|
Zfish  1532 REDSAFQKLLRG 1543

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Mrp4NP_650086.2 CFTR_protein 12..1277 CDD:273530 441/1363 (32%)
ABC_membrane 93..359 CDD:294371 74/265 (28%)
ABCC_MRP_domain1 422..622 CDD:213217 92/202 (46%)
ABC_membrane 735..978 CDD:294371 76/277 (27%)
ABCC_MRP_domain2 1051..1272 CDD:213211 119/222 (54%)
abcc10XP_005155817.1 SunT 248..1531 CDD:331423 434/1346 (32%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C170586033
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0054
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D138195at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100026
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
54.650

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