DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mrp4 and abcc8

DIOPT Version :9

Sequence 1:NP_650086.2 Gene:Mrp4 / 41387 FlyBaseID:FBgn0263316 Length:1316 Species:Drosophila melanogaster
Sequence 2:XP_005170744.1 Gene:abcc8 / 553281 ZFINID:ZDB-GENE-050517-22 Length:1594 Species:Danio rerio


Alignment Length:1361 Identity:420/1361 - (30%)
Similarity:680/1361 - (49%) Gaps:180/1361 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly    60 RLCAAWDEQVAKNETPRLG-----RALTKVFGFHLFITGVFLLAQEFLTKVTQPICLIGVMAYFA 119
            :|..|::.|....:||..|     .||.:.||..|.::..:....:.| ....|:|:.|::.:.:
Zfish   278 KLRQAFEAQKGPQDTPPQGSKWIWAALRQAFGKPLILSITYRFMADLL-GFAGPLCISGIVHHLS 341

  Fly   120 GND-----PDR-------SKAQLWAAGLIAGSV--FSVCIGHPYMLG----LLHLGMKMRIALSS 166
            ..:     |.:       |..:..|.|.:...:  |::.:...::..    .:..|:.:|.|:.:
Zfish   342 KENHTILPPVKHLGMYFISSQEFLANGYVLAVLLFFALLLQRTFLQASYYVAIETGINLRGAIQT 406

  Fly   167 LIYRKALRL--SRTALGDTTVGQVVNLLSNDVGRFDLVLINVHYLWIAPLELIAVTYLMYLEIGI 229
            .|:.|.:||  |..::|..||||:.||::.|..:..........|:..|:::|....|:|..:||
Zfish   407 KIFNKIMRLCTSNLSMGGMTVGQICNLVAIDTNQLMWFFFLCPNLFAMPVQIIVGIILLYYLLGI 471

  Fly   230 SSMFGVAIMLLFLPFQSYLGKRTSVLRLRTALRTDERVRMMNEIISGIQVIKMYAWEKPFGKVVE 294
            |::.|..|:.|..|.|.::..:.|..:..|...:.||::..||::.||:::|:||||..|...||
Zfish   472 SALIGATIITLLAPVQYFVATKLSDAQKSTLEYSSERLKKTNELLRGIKLLKLYAWEHIFCSNVE 536

  Fly   295 MTRFNEMLCIKQVNYIRGILISFAMFLS-RIFTSSSL-IAFVLLGNI----------LNAEKAFF 347
            .||..|:..::          :||::.| .||.:::: ||.||:..:          |:...||.
Zfish   537 ETRCKELTSLQ----------AFALYTSISIFMNTAIPIAAVLVTFVAHVHLSDDADLSPAVAFA 591

  Fly   348 VTAYYNILRRSVTMFF--PQGISEFAELLVSVRRLEAFM--------HRPETKVRDKS------- 395
            ..:.::||   ||..|  ...:....:.||||::|..|.        ..|...|...|       
Zfish   592 SLSLFHIL---VTPLFLLSSVVRSTVKALVSVQKLSEFFSCDEIGGEQEPRATVVPNSTNHNKYQ 653

  Fly   396 --KVKNANQK-----------AESPNGDSPKGNGIPENLIEFSQFQARWESHSLEPTLEDINLQL 447
              .:|..|:|           .:|...|.....|..:..|:.:.....|...:  .||.::|:::
Zfish   654 ALPLKVVNRKRPVREDWNSFALQSEQEDEVLAVGDEDICIKITNGYFSWTEGT--STLSNVNIKI 716

  Fly   448 GRRKLVAVIGPVGAGKSSLIQAILGELPGESGT-------------------------LRINGSY 487
            ...:|..::|.||.|||||:.|.|||:...|||                         :|..|:.
Zfish   717 PFGQLTMIVGQVGCGKSSLLLAALGEMQKISGTVIWNRMPTLDAEGNESLPDAAAEGDIRKRGAV 781

  Fly   488 SYAAQEPWLFTGTVRQNILFGLDWDKHRYRTVVKKCALERDFELLPFGDKTIVGERGASLSGGQK 552
            :||:|:|||...|:.:||.|.:...|.|||.|::.|:|:.|.::||.||:||:||||..|||||:
Zfish   782 AYASQKPWLLNTTLAENITFEMPLIKQRYRAVIEACSLQPDIDILPQGDQTIIGERGIILSGGQR 846

  Fly   553 ARISLARAVYRRADIYLLDDPLSAVDTHVGRHLFDQCMRGYLRSE--LVILVTHQLQFLEQADLI 615
            .|||:|||:|:..::..||||.||:|.|:..||..:.:...||.|  .|::|||:||:|..||.|
Zfish   847 QRISVARALYQTTNVVFLDDPFSALDIHLSDHLMQEGILKLLREEKRTVVIVTHKLQYLPHADWI 911

  Fly   616 VIMDKGRISAMGTYSSMKRSGLD-FAQLLTAPNK-----DAEDLDEIDGAGGDGLDLLNVPSLSR 674
            :.|..|.|...||...:::|..: |.|..|..::     :.|.:||            |:..|.|
Zfish   912 IAMKDGSIQTEGTLKDIQKSQPELFEQWKTLMHRQDKEFEKETVDE------------NMTVLER 964

  Fly   675 RGSKNSKPSTRNNSFTSLSSMAESMAQEASLQ-------MQETRVEGKIGLGLYKEYLTSGSSWF 732
            :       :.|...::..:...|...:|.||:       .|..|....|.......||:|..   
Zfish   965 K-------NLRRAMYSREALKTEEDEEEESLESDDDDNLSQVMRHRATIPWRSCGTYLSSAG--- 1019

  Fly   733 MIFFMVFLCLATQI----LCSAADYFLSYWVDKNVDGQTDIN------------TDPQDMYYFAA 781
              ..::.|.|.:|:    |..|.||:|::|..|.:..:.|..            |....:..|:.
Zfish  1020 --LLLLLLLLLSQLLKHSLLVAIDYWLAHWTSKVITAKIDAAAHNCSLVQDIGFTHSSYLLVFSL 1082

  Fly   782 LNVAVVVFTIVRTMLFYKMAMRSSTQLHNAMYQGITRAAMYFFNTNPSGRILNRFSKDLGQLDEV 846
            |....:|..:..::......:|.:.:||:.:...|..|.|..|.|.|.|.||||||.|...:|:.
Zfish  1083 LCCLGIVLCLATSVAVEWTGLRVAKELHHNLLSNIILAPMRLFETTPLGSILNRFSSDTNTIDQH 1147

  Fly   847 LPSVMLDVVQLFLTLLGIIVVICITNPYYLILTLALAIIFYYIREFYLKTSRDVKRLEAVARSPI 911
            :|:.:..:.:..|..:..:.||....|.:||:...|.|..|:|::::...|:|:::||...:.|:
Zfish  1148 IPATLECLSRSTLLCVSALGVISYVTPVFLIVLAPLTIACYFIQKYFRVASKDLQQLEDSTQLPL 1212

  Fly   912 YSHLSATITGLPTIRALGAQ---KELIAEFDNLQDLHSSGYYTFL-ATNR----AFGYYLDCFCT 968
            .||.|.|:.||.||||...:   ::.:.:|.:..::.|    .|| |.||    ...|...|...
Zfish  1213 LSHFSETVEGLTTIRAFRYEPRFRQRLLQFTDANNMAS----LFLTAANRWLEVRMEYIGACIVL 1273

  Fly   969 LYIVIIILNYFINPPQSPGEVGLAITQAMGMTGMVQWAMRQSAELENTMTAVERVVEYDEIEPEG 1033
            :..|..|.|...: ..|.|.|||.:|.|:.::..:.|.:|..|::|..:.||:|:......|||.
Zfish  1274 IAAVASITNSLYS-HLSTGLVGLGLTYALMVSNYLNWMVRNLADMEVQLGAVKRIKALLRTEPEN 1337

  Fly  1034 EFDSREGKKPSPSWPEKGEIIAEDLCLRYFPDPQAKYVLKALNFRIRPCEKVGIVGRTGAGKSSL 1098
            ........:....||::|||..::|.:||  |...|.|||.:|..|:|.:|:||.||||:||||.
Zfish  1338 YEGLLSASQVPEGWPQQGEIQIQNLSVRY--DSTLKPVLKHVNAHIKPGQKLGICGRTGSGKSSF 1400

  Fly  1099 INALFRL-SYNEGIITIDERDTADMGLFDLRSKISIIPQEPVLFSGSMRYNLDPFEEYNDAKLWD 1162
            ..|.||: ...||.|.||:.|.|.:.|..|||:.|||.|:|.||||::|:||||..:..|:.||:
Zfish  1401 SLAFFRMVDTFEGRIIIDDIDIAKLPLQTLRSRFSIIQQDPFLFSGTIRFNLDPEMKATDSMLWE 1465

  Fly  1163 ALEEVKLKPLISELPNGLQSKISEGGSNFSVGQRQLVCLARAILRENRVLVMDEATANVDPQTDA 1227
            |||..:|||::..||.||.:.|:|||.|||.|||||.|||||.:|::.:|:||||||::|..|::
Zfish  1466 ALEIAQLKPVVKTLPGGLDAIITEGGENFSQGQRQLFCLARAFVRKSSILIMDEATASIDMATES 1530

  Fly  1228 LIQATIRSKFRDCTVLTIAHRLNTIMDSDRVLVMDAGHLVEFGSPYELLTSSESKIFHGMV 1288
            ::|..:.:.|.|.||:|||||::||:::|.|:||..|.::||..| |:|...|..:|...|
Zfish  1531 ILQKVVMTAFADRTVVTIAHRVHTILNADLVIVMKRGVILEFDKP-EVLLDQEDSVFASFV 1590

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Mrp4NP_650086.2 CFTR_protein 12..1277 CDD:273530 416/1348 (31%)
ABC_membrane 93..359 CDD:294371 71/297 (24%)
ABCC_MRP_domain1 422..622 CDD:213217 87/226 (38%)
ABC_membrane 735..978 CDD:294371 70/266 (26%)
ABCC_MRP_domain2 1051..1272 CDD:213211 112/221 (51%)
abcc8XP_005170744.1 MRP_assoc_pro 39..1591 CDD:188098 420/1361 (31%)
ABC_membrane <388..603 CDD:294371 64/227 (28%)
P-loop_NTPase 693..918 CDD:304359 87/226 (38%)
ABC_membrane 1038..1307 CDD:279056 74/273 (27%)
P-loop_NTPase 1355..1594 CDD:304359 118/239 (49%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C170586053
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0054
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D138195at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100026
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
54.650

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