DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mrp4 and l(2)03659

DIOPT Version :9

Sequence 1:	NP_650086.2	Gene:	Mrp4 / 41387	FlyBaseID:	FBgn0263316	Length:	1316	Species:	Drosophila melanogaster
Sequence 2:	NP_001260823.1	Gene:	l(2)03659 / 47905	FlyBaseID:	FBgn0010549	Length:	1374	Species:	Drosophila melanogaster

Alignment Length:	1323	Identity:	707/1323 - (53%)
Similarity:	937/1323 - (70%)	Gaps:	51/1323 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 QSMKADELPENPRERSSPLSSLMFCFALPVLFKGRKKTLEQKDLYRALKEHKSDSLGDRLCAAWD 66
            |:.|...||||||.||:.:|||.|.:.:|:..||.:|||:..||||.|:|.|||.||:||||:|:
  Fly    79 QNEKEKVLPENPRARSNFISSLCFWYTIPIFRKGYRKTLDSTDLYRPLEEQKSDILGNRLCASWE 143

  Fly    67 EQVAKNE--TPRLGRALTKVFGFHLFITGVFLLAQEFLTKVTQPICLIGVMAYFAGNDPDRSKAQ 129
            .:: ||:  :|.|.|||.:|||:.|...|:.:...|...:..|||.|:.:::||:| :||.:.|.
  Fly   144 REL-KNDGRSPSLVRALLRVFGWQLGFPGLAIFVVELGLRTLQPIFLVKLISYFSG-EPDAANAG 206

  Fly   130 L-WAAGLIAGSVFSVCIGHPYMLGLLHLGMKMRIALSSLIYRKALRLSRTALGDTTVGQVVNLLS 193
            . :|...|..|..:|.|..|...|:.|:..|||:|:.|:|:||||||::.||||||.|.||||:|
  Fly   207 FYYAVAQIVISALTVMILTPTTFGIHHVCFKMRVAMGSMIFRKALRLTKGALGDTTSGHVVNLIS 271

  Fly   194 NDVGRFDLVLINVHYLWIAPLELIAVTYLMYLEIGISSMFGVAIMLLFLPFQSYLGKRTSVLRLR 258
            ||:.|.|.....|||||:.||:::.:|||||.|||||::|||..||||:|.|.|||.|||.::|:
  Fly   272 NDIPRLDSAPYTVHYLWVGPLQVLVITYLMYQEIGISAVFGVLFMLLFMPIQMYLGTRTSAIQLK 336

  Fly   259 TALRTDERVRMMNEIISGIQVIKMYAWEKPFGKVVEMTRFNEMLCIKQVNYIRGILISFAMFLSR 323
            .|.|||.|:||:|||||.|||:||||||:||.::|...|..||..|:|..||||...:..:.|||
  Fly   337 AAERTDNRIRMVNEIISAIQVLKMYAWEQPFEQMVTHAREKEMNTIRQGQYIRGFDFARRIVLSR 401

  Fly   324 IFTSSSLIAFVLLGNILNAEKAFFVTAYYNILRRSVTMFFPQGISEFAELLVSVRRLEAFMHRPE 388
            :....||:.:|:||.:...|.||.:|||||:|..:::::.|..|.:.|:.|.|:||:|.||...|
  Fly   402 VAIFLSLVGYVILGKVFTPEIAFMITAYYNVLLAAMSIYVPSAIIQTAQFLTSIRRVEQFMQSEE 466

  Fly   389 TKVRDKSKVKNANQKAESPNGDSPKGNGIPEN---------LIEFSQFQARWESHSLEPTLEDIN 444
            ....|||         |.|:.|:..||. |.|         .|.....:|:|:.:|.:.||..||
  Fly   467 LGSSDKS---------EGPSKDTVPGNP-PSNNNEADLLKSAISIRDLKAKWDPNSPDYTLSGIN 521

  Fly   445 LQLGRRKLVAVIGPVGAGKSSLIQAILGELPGESGTLRINGSYSYAAQEPWLFTGTVRQNILFGL 509
            |::....:|||||..|:|||||||||||||...||.|::|||.||.:||.|||:||||||||||.
  Fly   522 LEIKPGSVVAVIGLTGSGKSSLIQAILGELKANSGQLQVNGSLSYTSQESWLFSGTVRQNILFGQ 586

  Fly   510 DWDKHRYRTVVKKCALERDFELLPFGDKTIVGERGASLSGGQKARISLARAVYRRADIYLLDDPL 574
            ..|..||..|||||||||||:|||..|.||||||||:|||||||||||||:|||:|.||||||||
  Fly   587 PMDSQRYEEVVKKCALERDFDLLPLRDNTIVGERGATLSGGQKARISLARSVYRKASIYLLDDPL 651

  Fly   575 SAVDTHVGRHLFDQCMRGYLRSELVILVTHQLQFLEQADLIVIMDKGRISAMGTYSSMKRSGLDF 639
            ||||..|.|||||||:||:||...|:|||||.|||...|.|||:..|:|.|:|.|.|:.::|
  Fly   652 SAVDASVARHLFDQCVRGHLRGSTVVLVTHQEQFLPHVDQIVILANGQIKALGDYESLLKTG--- 713

  Fly   640 AQLLTAPNKDAEDLDEIDGAGGDGLDLLNVPSLSRRGSKNSKPSTRNNSFTSLSSMAESMAQEAS 704
              |:|.    ...|.:.|.|..:..:.||   |:...:||.....:.||..::..   |.:.:..
  Fly   714 --LITG----LGSLSKTDKAKTEEQEPLN---LNSPDNKNEVTPIKENSEQTVGG---SSSGKEH 766

  Fly   705 LQMQETRVEGKIGLGLYKEYLTSGSSWFMIFFMVFL--CLATQILCSAADYFLSYWVDKNVDG-- 765
            ::.||:   |.|.|.||::|..:|..  ::.|:|.|  .:..|:..:..||||:|||.|....
  Fly   767 VERQES---GGISLALYRKYFQAGGG--LVAFLVMLSSSVLAQVAVTGGDYFLTYWVKKESTAAG 826

  Fly   766 ---QTDINTDPQDMYYFAALNVAVVVFTIVRTMLFYKMAMRSSTQLHNAMYQGITRAAMYFFNTN 827
               ..|:.:...|:|.:..:.:..|:..:..:.|.:.:|.::|.:|||.::..:|||.|:||:.|
  Fly   827 HGEMEDMESKSMDVYKYTLIIILSVIMNLSSSFLLFNIAKKASIRLHNTIFNRVTRADMHFFSIN 891

  Fly   828 PSGRILNRFSKDLGQLDEVLPSVMLDVVQLFLTLLGIIVVICITNPYYLILTLALAIIFYYIREF 892
            ..|.|||||:||:.|:|||||.|::||:|:.|.|.|||:||...||..|:.||.|::|||::|..
  Fly   892 KHGSILNRFTKDMSQVDEVLPVVLVDVMQIALWLAGIIIVIANVNPLLLVPTLMLSVIFYHLRNL 956

  Fly   893 YLKTSRDVKRLEAVARSPIYSHLSATITGLPTIRALGAQKELIAEFDNLQDLHSSGYYTFLATNR 957
            |||||||:||:||:.|||:||||:|::.||.|||||.||:.|..|||:.||.|||.::.:::|::
  Fly   957 YLKTSRDLKRVEAINRSPVYSHLAASLNGLTTIRALDAQRVLEKEFDSYQDAHSSAFFMYISTSQ 1021

  Fly   958 AFGYYLDCFCTLYIVIIILNYFINPPQSPGEVGLAITQAMGMTGMVQWAMRQSAELENTMTAVER 1022
            ||||.::|.|.:||.||.|::|..||.:..:|||.||||||:..||||.:||:||||||||||||
  Fly  1022 AFGYCMNCICVIYISIITLSFFAFPPGNGADVGLVITQAMGLIDMVQWGVRQTAELENTMTAVER 1086

  Fly  1023 VVEYDEIEPEGEFDSREGKKPSPSWPEKGEIIAEDLCLRYFPDPQAKYVLKALNFRIRPCEKVGI 1087
            ||||:.|||||..::.:.|||..:|||:||||.::|.|||.|:.:|:.|||:|:|.|:|.|||||
  Fly  1087 VVEYESIEPEGMLEAPDDKKPPKTWPEQGEIIFKELNLRYTPNAKAENVLKSLSFVIQPREKVGI 1151

  Fly  1088 VGRTGAGKSSLINALFRLSYNEGIITIDERDTADMGLFDLRSKISIIPQEPVLFSGSMRYNLDPF 1152
            ||||||||||||||||||||.:|.:.||.|||..|||.|||.:|||||||||||||:||||||||
  Fly  1152 VGRTGAGKSSLINALFRLSYTDGSVLIDTRDTRQMGLHDLRRQISIIPQEPVLFSGTMRYNLDPF 1216

  Fly  1153 EEYNDAKLWDALEEVKLKPLISELPNGLQSKISEGGSNFSVGQRQLVCLARAILRENRVLVMDEA 1217
            :||:|.|||..|||||||.::|:||:||.|||||||:|||||||||||||||||||||:||||||
  Fly  1217 DEYSDEKLWGCLEEVKLKEVVSDLPDGLASKISEGGTNFSVGQRQLVCLARAILRENRILVMDEA 1281

  Fly  1218 TANVDPQTDALIQATIRSKFRDCTVLTIAHRLNTIMDSDRVLVMDAGHLVEFGSPYELLTSSESK 1282
            |||||||||.||||||||||||||||||||||:||:|||:|:|||||.:|||||||||:|.|:||
  Fly  1282 TANVDPQTDGLIQATIRSKFRDCTVLTIAHRLHTIIDSDKVMVMDAGRVVEFGSPYELMTKSDSK 1346

  Fly  1283 IFHGMVMETGQNTFDSLLKVAEK 1305
            :||.:|.::|:.:::.|||:|::
  Fly  1347 VFHNLVNQSGRASYEGLLKIAQE 1369

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mrp4	NP_650086.2	CFTR_protein	12..1277	CDD:273530	690/1283 (54%)
		ABC_membrane	93..359	CDD:294371	131/266 (49%)
		ABCC_MRP_domain1	422..622	CDD:213217	131/199 (66%)
		ABC_membrane	735..978	CDD:294371	113/249 (45%)
		ABCC_MRP_domain2	1051..1272	CDD:213211	173/220 (79%)
l(2)03659	NP_001260823.1	CFTR_protein	89..1343	CDD:273530	691/1285 (54%)
		ABC_membrane	171..437	CDD:294371	131/266 (49%)
		ABCC_MRP_domain1	499..699	CDD:213217	131/199 (66%)
		ABC_membrane	799..1045	CDD:294371	111/245 (45%)
		ABCC_MRP_domain2	1115..1336	CDD:213211	173/220 (79%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45440882
Domainoid	1	1.000	179	1.000	Domainoid score	I1056
eggNOG	1	0.900	-	-		E2759_KOG0054
Homologene	1	1.000	-	-		H74563
Inparanoid	1	1.050	1131	1.000	Inparanoid score	I210
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	1	1.000	-	-		FOG0001028
OrthoInspector	1	1.000	-	-		otm26173
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	1	1.100	-	-	P	PTHR24223
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X771
	13	12.810