DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mrp4 and CG5789

DIOPT Version :9

Sequence 1:NP_650086.2 Gene:Mrp4 / 41387 FlyBaseID:FBgn0263316 Length:1316 Species:Drosophila melanogaster
Sequence 2:NP_001247286.1 Gene:CG5789 / 42928 FlyBaseID:FBgn0039207 Length:1402 Species:Drosophila melanogaster


Alignment Length:1428 Identity:614/1428 - (42%)
Similarity:841/1428 - (58%) Gaps:167/1428 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly    11 ENPRERSSPLSSLMFCFALPVLFKGRKKTLEQKDLYRALKEHKSDSLGDRLCAAWDEQV----AK 71
            :|||:.::.:|.|:|.:|:|:|::|.::.|...||.:.|||.:|:.|||||...|.:::    .|
  Fly    10 KNPRQHANIISQLIFAWAIPLLYRGSRRGLNTDDLTQCLKEDRSEQLGDRLEDQWFKELERSHRK 74

  Fly    72 NETPRLGRALTKVFGFHLFITGVF-------------LLAQEFLTKVTQPIC------------- 110
            .:.|.|..||.:.|.....|.|:.             :|||..:.....|:.             
  Fly    75 KQKPHLRNALFRCFLGPTIINGLICFIYIVIKTLIPAVLAQLLIQFQKTPVAQLRNIDVNDISIS 139

  Fly   111 --------------LIGVMAYFAGN----------------DP-------------------DRS 126
                          |...:|..:|:                :|                   |::
  Fly   140 DSLNRTARAIPNYVLSQAVANSSGSPGDALFPKSLDKAGPLEPIQPPVEEVDHNATAVRSILDQT 204

  Fly   127 KAQLW------AAGLIAGSVFSVCIGHPYMLGLLHLGMKMRIALSSLIYRKALRLSRTALGDTTV 185
            ...:|      .|.|:..::|...:.|...|....:|.:||||..||||||.||||....|.|..
  Fly   205 VEHMWNDMNSLGAVLVLSTLFCCFLLHHVDLRQRLMGARMRIACCSLIYRKTLRLSMKTAGQTPA 269

  Fly   186 GQVVNLLSNDVGRFDLVLINVHYLWIAPLELIAVTYLMYLEIGISSMFG-VAIMLLFLPFQSYLG 249
            |.::|||||||.|.|...|.:|::||.||:.:...||::|.|||.::.| |.::|..:|.|:.|.
  Fly   270 GYLINLLSNDVNRLDYGFIFMHWIWIMPLQAMLTCYLIWLNIGIPAIVGVVGLLLKTVPVQTALS 334

  Fly   250 KRTSVLRLRTALRTDERVRMMNEIISGIQVIKMYAWEKPFGKVVEMTRFNEMLCIKQVNYIRGIL 314
            |.|||||:|.|.|||.||.:|||::.||||||||||||||..||...|.:|:..|:..:|:||..
  Fly   335 KVTSVLRMRIAERTDARVGIMNELVQGIQVIKMYAWEKPFQAVVAEARRSEIKQIRYASYLRGFY 399

  Fly   315 ISFAMFLSRIFTSSSLIAFVLLGNILNAEKAFFVTAYYNILRRSVTMFFPQGISEFAELLVSVRR 379
            :|..:|..|.....:|.|..|:|..:.|:..|...:|||||:....:::|..:|..||.|||:||
  Fly   400 LSTMVFTERSTLYITLAAAALMGQTITADFVFSAASYYNILQLVAAIWYPLAVSFGAEALVSLRR 464

  Fly   380 LEAFM---HRPETKVRDKSKVKNANQKAESPNGDSPKGNGIPENLIEFSQFQARWESHSLEPTLE 441
            ::.|:   .|.|       :.:....|.:...|||        ..:......|.|:....:.||:
  Fly   465 IQDFLMLEGREE-------RTQGLTHKRDQEGGDS--------RAVTIKDINASWDIEKPQKTLQ 514

  Fly   442 DINLQLGRRKLVAVIGPVGAGKSSLIQAILGELPGESGTLRINGSYSYAAQEPWLFTGTVRQNIL 506
            .||||:.:.:|.||||||||||||::|.:|||||...|.:.|.|..||||||||||||:||.|||
  Fly   515 SINLQIEKGQLCAVIGPVGAGKSSILQLLLGELPVIDGGVFIQGDLSYAAQEPWLFTGSVRNNIL 579

  Fly   507 FGLDWDKHRYRTVVKKCALERDFELLPFGDKTIVGERGASLSGGQKARISLARAVYRRADIYLLD 571
            ||.::|:.||:.|.:.|||..||:.||.||||:||||||||||||:||||||||||:.|.|||:|
  Fly   580 FGEEFDRKRYQEVTRCCALSTDFQQLPNGDKTLVGERGASLSGGQRARISLARAVYKPAQIYLMD 644

  Fly   572 DPLSAVDTHVGRHLFDQCM--RGYLRSELV---ILVTHQLQFLEQADLIVIMDKGRISAMGTYSS 631
            |||||||.||||||||:.:  ||.| ::|.   ||||||:.||.:||:|||:|:|||...|||..
  Fly   645 DPLSAVDAHVGRHLFDEVIGPRGRL-AQLKATRILVTHQVHFLSEADVIVIVDQGRILRQGTYQE 708

  Fly   632 MKRSGLDFAQLLTAPNK---------------------DAEDLDEIDGAGGDGLDLLNVPSLSRR 675
            :..|.||||:||..|.:                     |.||:..|||. .||...|...|.|..
  Fly   709 LINSDLDFARLLERPKEEEEGENSRNQTSPLSVNSLESDDEDIPFIDGV-KDGYQQLRKQSSSVH 772

  Fly   676 GSKNSKPSTRNNSFTSLSSMAESMAQEASLQMQETRVEGKIGLGLYKEYLTSGSSWFMIFFMVFL 740
            ||| |..||:.:.......:||:.|            .|.|...::.||..:||:.....||||:
  Fly   773 GSK-SLDSTQLDDNVDEDDLAEAQA------------SGGISPRVWYEYFHAGSTLLSFSFMVFV 824

  Fly   741 CLATQILCSAADYFLSYWVD---KNVDGQTDINTDPQDMYYFAALNVAVVVFTIVRTMLFYKMAM 802
            .:.:|::||::|:|.:.|..   :...|:...:|. :.||.:.||.:|||:.|..|..||:|:.|
  Fly   825 MVMSQVVCSSSDFFANIWTQQEHQRSQGEATFSTF-ECMYIYGALIIAVVIMTTFRGFLFFKICM 888

  Fly   803 RSSTQLHNAMYQGITRAAMYFFNTNPSGRILNRFSKDLGQLDEVLPSVMLDVVQLFLTLLGIIVV 867
            .:|..||:.|:..|..|.|.||:|.||||||||||||:|.:||:||..|:|.:|:.|.:.||::|
  Fly   889 HASKVLHDRMFACILHATMRFFDTTPSGRILNRFSKDMGAIDELLPRAMMDFIQIALVMFGILIV 953

  Fly   868 ICITNPYYLILTLALAIIFYYIREFYLKTSRDVKRLEAVARSPIYSHLSATITGLPTIRALGAQK 932
            |.|.||..:...|.:|::...|.:.||:.|:|:||||.:.|||::|||||::|||..||:...|.
  Fly   954 IGILNPVLVAAMLVVAVVDVLILKLYLRPSQDLKRLEGICRSPVFSHLSASLTGLAIIRSRQLQD 1018

  Fly   933 ELIAEFDNLQDLHSSGYYTFLATNRAFGYYLDCFCTLYIVIIILNYFINPPQS-PGEVGLAITQA 996
            .:..|||.|||:|||.:...:|.|...|.:|||...:::..:..::.|:...: .|.|||||.||
  Fly  1019 VVAKEFDLLQDVHSSVWQLTMAVNTTLGLWLDCVSCIFLTSVTFSFIISSETTYSGNVGLAIAQA 1083

  Fly   997 MGMTGMVQWAMRQSAELENTMTAVERVVEYDEIEPE---GEFDSREGKKPSPSWPEKGEIIAEDL 1058
            |.:|||||:.:||.||....||:||||::|.|:|.|   ||      |.|...||.:|::...::
  Fly  1084 MILTGMVQYGVRQVAESLQQMTSVERVLQYTELEQEPALGE------KTPPQQWPTRGQVEFRNM 1142

  Fly  1059 CLRYFPDPQAKYVLKALNFRIRPCEKVGIVGRTGAGKSSLINALFRLSYNEGIITIDERDTADMG 1123
            ..||  ||....||:.||..|....||||||||||||||||.|||||::.||.|.||..:|..:.
  Fly  1143 SCRY--DPNGSPVLRNLNLTIEAGWKVGIVGRTGAGKSSLIGALFRLAHIEGEIFIDGIETGTIS 1205

  Fly  1124 LFDLRSKISIIPQEPVLFSGSMRYNLDPFEEYNDAKLWDALEEVKLKPLISELPNGLQSKISEGG 1188
            |..||::||||||:|||||.::||||||||.|.||:||.|||:|:|:..|.    ||...::|.|
  Fly  1206 LEILRTRISIIPQDPVLFSATIRYNLDPFERYTDAELWSALEDVELRKAIP----GLDYMVTERG 1266

  Fly  1189 SNFSVGQRQLVCLARAILRENRVLVMDEATANVDPQTDALIQATIRSKFRDCTVLTIAHRLNTIM 1253
            .|||||||||:||||||||.|:|||:||||||||||||||||.|||.||:.|||||:||||:|:|
  Fly  1267 GNFSVGQRQLLCLARAILRNNKVLVLDEATANVDPQTDALIQRTIRIKFKQCTVLTVAHRLHTVM 1331

  Fly  1254 DSDRVLVMDAGHLVEFGSPYELLTSSESKIFHGMVMETGQNTFDSLLKVAEKAHLESMKPKSE 1316
            ||||::|||||..|||..||.||..|:..: ..||..||..: ::|.|.|..:|....:.:.|
  Fly  1332 DSDRIIVMDAGVAVEFDVPYLLLKKSQGHL-RQMVEATGGES-EALKKTASDSHKRMQRERDE 1392

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Mrp4NP_650086.2 CFTR_protein 12..1277 CDD:273530 603/1386 (44%)
ABC_membrane 93..359 CDD:294371 113/347 (33%)
ABCC_MRP_domain1 422..622 CDD:213217 124/204 (61%)
ABC_membrane 735..978 CDD:294371 103/245 (42%)
ABCC_MRP_domain2 1051..1272 CDD:213211 139/220 (63%)
CG5789NP_001247286.1 CFTR_protein 9..1367 CDD:273530 607/1400 (43%)
ABC_membrane 214..441 CDD:294371 101/226 (45%)
ABCC_MRP_domain1 495..699 CDD:213217 124/204 (61%)
ABC_membrane 863..1088 CDD:294371 100/224 (45%)
ABCC_MRP_domain2 1135..1350 CDD:213211 139/220 (63%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 86 1.000 Domainoid score I2776
eggNOG 1 0.900 - - E2759_KOG0054
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 133 1.000 Inparanoid score I246
Isobase 1 0.950 - 0 Normalized mean entropy S1171
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D138195at2759
OrthoFinder 1 1.000 - - FOG0001028
OrthoInspector 1 1.000 - - otm14754
orthoMCL 1 0.900 - - OOG6_100026
Panther 1 1.100 - - P PTHR24223
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X771
1110.820

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