DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mrp4 and abcc4

DIOPT Version :9

Sequence 1:	NP_650086.2	Gene:	Mrp4 / 41387	FlyBaseID:	FBgn0263316	Length:	1316	Species:	Drosophila melanogaster
Sequence 2:	NP_001007039.2	Gene:	abcc4 / 368620	ZFINID:	ZDB-GENE-030616-511	Length:	1331	Species:	Danio rerio

Alignment Length:	1353	Identity:	591/1353 - (43%)
Similarity:	852/1353 - (62%)	Gaps:	99/1353 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MQSMKADELPENPRERSSPLSSLMFCFALPVLFKGRKKTLEQKDLYRALKEHKSDSLGDRLCAAW 65
            |:.:|.| ...||...::..|.:.||:..|:...|.|:.||:.|::..|.|.:|..||:.|.:.|
Zfish     5 MEPIKKD-AKSNPSASANLFSQIFFCWLNPLFSIGSKRRLEEDDMFNVLPEDRSKKLGEELQSYW 68

  Fly    66 D---EQVAKN-ETPRLGRALTKVFGFHLFITGVFLLAQEFLTKVTQPICLIGVMAYFAGNDPD-- 124
            |   |:.||. :||:|.:|:.:.:.....:.|||.|.:|.: ||.||:.|..::.||.....|
Zfish    69 DQEKEKAAKELKTPKLTKAIIRCYWKSYAVLGVFTLIEESI-KVIQPVFLGKLIKYFENYRHDDM 132

  Fly   125 --RSKAQLWAAGLIAGSVFSVCIGHPYMLGLLHLGMKMRIALSSLIYRKALRLSRTALGDTTVGQ 187
              .|:|..:|.|:...::....:.|.|...:...|||:|||:..:||||||.||..|:|.||.||
Zfish   133 AALSEAYGYATGVCLSTLGLALLHHLYFYHVQRAGMKIRIAMCHMIYRKALCLSAAAMGQTTTGQ 197

  Fly   188 VVNLLSNDVGRFDLVLINVHYLWIAPLELIAVTYLMYLEIGISSMFGVAIMLLFLPFQSYLGKRT 252
            :||||||||.:||.:.|.:|:||:.||:..||..|::.|||.|.:.|:|:::..:|.|:..||..
Zfish   198 IVNLLSNDVNKFDELTIFLHFLWVGPLQAAAVIGLLWQEIGPSCLAGMAVLVFLMPLQTMFGKLF 262

  Fly   253 SVLRLRTALRTDERVRMMNEIISGIQVIKMYAWEKPFGKVVEMTRFNEMLCIKQVNYIRGILISF 317
            |..|.:||..||.|:|.|||::|||::||||||||||..:|...|..|:..|...:|:||  ::.
Zfish   263 SKYRSKTAALTDSRIRTMNEVVSGIRIIKMYAWEKPFAMLVNDVRRKEISKIMSSSYLRG--LNM 325

  Fly   318 AMFLSRIFTSSSLIAF------VLLGNILNAEKAFFVTAYYNILRRSVTMFFPQGISEFAELLVS 376
            |.|    ||::.:|.|      ||:||.::|.:.|...:.|:.:|.:||:|||..|.:.:|..:|
Zfish   326 ASF----FTANKIILFVTFTVYVLVGNTMSASRVFVAVSLYSAVRLTVTLFFPAAIEKVSESAIS 386

  Fly   377 VRRLEAFMHRPETKVRDKSKVKN----ANQKAESPNGDSPKGNGIPENLIEFSQFQARWESHSLE 437
            :||::.|:...|.       |||    :.::.:.|:             :|.......|:.....
Zfish   387 IRRIKKFLLLDEL-------VKNHLPLSQEEKKEPS-------------VEMQDLICYWDKTLDA 431

  Fly   438 PTLEDINLQLGRRKLVAVIGPVGAGKSSLIQAILGELPGESGTLRINGSYSYAAQEPWLFTGTVR 502
            |||:::...:...:|:|||||||||||||:..:|||||.|.|.:::.|..:||:|:||:|.||:|
Zfish   432 PTLQNVCFTVKPGQLLAVIGPVGAGKSSLLSTVLGELPAEKGVIKVKGELTYASQQPWVFPGTIR 496

  Fly   503 QNILFGLDWDKHRYRTVVKKCALERDFELLPFGDKTIVGERGASLSGGQKARISLARAVYRRADI 567
            .|||||.:....||..|::.|||:||.||||.||.|::|:|||:||||||||::||||||:.|||
Zfish   497 SNILFGKELQPQRYERVLRACALKRDMELLPDGDLTVIGDRGATLSGGQKARVNLARAVYQDADI 561

  Fly   568 YLLDDPLSAVDTHVGRHLFDQCMRGYLRSELVILVTHQLQFLEQADLIVIMDKGRISAMGTYSSM 632
            |||||||||||..|.||||:||:.|.|:.:..||||||||:|:.|:.|:::.:|.:.|.|:||.:
Zfish   562 YLLDDPLSAVDAEVSRHLFEQCVCGILKDKPRILVTHQLQYLKAANQILVLKEGHMVARGSYSEL 626

  Fly   633 KRSGLDFAQLLTAPNKDAEDLDEIDGAGGDGLDLLNVPSLSRRGSKNSKPSTRNNSFTSLSSMAE 697
            ::|||||..||   .||.|:                 .|.|.:|.....|.:|..|..|:.|.:.
Zfish   627 QQSGLDFTSLL---KKDEEE-----------------ESGSEKGEAPRSPRSRTVSQNSVRSHSS 671

  Fly   698 SM-----------AQEASLQMQETRVEGKIGLGLYKEYLTSGSSWFMIFFMVFLCLATQILCSAA 751
            |:           |:......:|.|.||.||:.:|.:|..:|::..|:..::.|.|..|......
Zfish   672 SVLSVKDDSDQLPAEPVHTMAEELRSEGNIGIRMYWKYFRAGANVVMLVLLLLLNLLAQTFYILQ 736

  Fly   752 DYFLSYW------VDKNVDGQTDINTDPQDM-------YY---FAALNVAVVVFTIVRTMLFYKM 800
            |::||||      :|.|.:.....||...:.       :|   :|.|..|.:||..:|.::.:..
Zfish   737 DWWLSYWATEQEKLDHNTNNTNTNNTSAGNTTQQLDLNFYLGIYAGLTGATIVFGFMRCLIMFNA 801

  Fly   801 AMRSSTQLHNAMYQGITRAAMYFFNTNPSGRILNRFSKDLGQLDEVLPSVMLDVVQLFLTLLGII 865
            .:.|:..|||.|:..|.|..:.||:.||.||||||||||:|.||.:||...:|.:|:||.::|:|
Zfish   802 LVSSAEMLHNRMFNSILRTPVRFFDINPIGRILNRFSKDIGHLDSLLPWTFVDFIQVFLQIVGVI 866

  Fly   866 VVICITNPYYLILTLALAIIFYYIREFYLKTSRDVKRLEAVARSPIYSHLSATITGLPTIRALGA 930
            .|.....|:.||..|.|.|.|.::|.::|:|||||||:|:..|||::||||:::.||.||||..|
Zfish   867 AVASSVIPWILIPVLPLLICFLFLRRYFLRTSRDVKRIESTTRSPVFSHLSSSLQGLWTIRAFKA 931

  Fly   931 QKELIAEFDNLQDLHSSGYYTFLATNRAFGYYLDCFCTLYIVIIILN-YFINPPQSPGEVGLAIT 994
            ::.....||..|||||..::.||.|:|.|...||..|::::.|.... ..:....:.|:||||::
Zfish   932 EERFQQTFDAHQDLHSEAWFLFLTTSRWFAVRLDGMCSVFVTITAFGCLLLKDTMNAGDVGLALS 996

  Fly   995 QAMGMTGMVQWAMRQSAELENTMTAVERVVEYDEIEPEGEFDSREGKKPSPSWPEKGEIIAEDLC 1059
            .|:.:.||.||.:|||||:||.||:|||||||.|:|.|..::::  |:|||.||.:|.|..:.:.
Zfish   997 YAVTLMGMFQWGVRQSAEVENMMTSVERVVEYTELESEAPWETQ--KRPSPDWPNRGLITFDRVN 1059

  Fly  1060 LRYFPDPQAKYVLKALNFRIRPCEKVGIVGRTGAGKSSLINALFRLSYNEGIITIDERDTADMGL 1124
            ..|..|  ...|||.::...||.|||||||||||||||||:||||||..||.|.:|...|:::||
Zfish  1060 FSYSSD--GPVVLKNISAMFRPREKVGIVGRTGAGKSSLISALFRLSEPEGKILVDGVLTSEIGL 1122

  Fly  1125 FDLRSKISIIPQEPVLFSGSMRYNLDPFEEYNDAKLWDALEEVKLKPLISELPNGLQSKISEGGS 1189
            .|||.|:|||||:||||:|:||.|||||.:::|..||.|||||:||..:.|||..|:::::|.||
Zfish  1123 HDLRQKMSIIPQDPVLFTGTMRKNLDPFNQHSDHDLWKALEEVQLKAAVEELPGKLETELAESGS 1187

  Fly  1190 NFSVGQRQLVCLARAILRENRVLVMDEATANVDPQTDALIQATIRSKFRDCTVLTIAHRLNTIMD 1254
            ||||||||||||||||||:||||::|||||||||:||.|||.|||.||::|||||||||||||:|
Zfish  1188 NFSVGQRQLVCLARAILRKNRVLIIDEATANVDPRTDELIQKTIRDKFKECTVLTIAHRLNTIID 1252

  Fly  1255 SDRVLVMDAGHLVEFGSPYELLTSSESKIFHGMVMETGQNTFDSLLKVAEKAH 1307
            |||:||:|||.:.|:.:|:.|| .::|.||:.||.:||:....|||:.|::|:
Zfish  1253 SDRILVLDAGRIHEYDAPHVLL-QNQSGIFYKMVQQTGKAEATSLLQTAKQAY 1304

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mrp4	NP_650086.2	CFTR_protein	12..1277	CDD:273530	575/1310 (44%)
		ABC_membrane	93..359	CDD:294371	113/275 (41%)
		ABCC_MRP_domain1	422..622	CDD:213217	108/199 (54%)
		ABC_membrane	735..978	CDD:294371	99/259 (38%)
		ABCC_MRP_domain2	1051..1272	CDD:213211	141/220 (64%)
abcc4	NP_001007039.2	SunT	11..1289	CDD:331423	582/1330 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586023
Domainoid	1	1.000	219	1.000	Domainoid score	I2575
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H74563
Inparanoid	1	1.050	1131	1.000	Inparanoid score	I210
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	1	1.000	-	-		FOG0001028
OrthoInspector	1	1.000	-	-		otm26173
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	1	1.100	-	-	O	PTHR24223
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X771
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	14	13.810