Protein Alignment Mrp4 and ABCC6

DIOPT Version :9

• Sequence 1: NP_650086.2
• Gene: Mrp4 / 41387
• FlyBaseID: FBgn0263316
• Length: 1316
• Species: Drosophila melanogaster
• Sequence 2: XP_024306029.1
• Gene: ABCC6 / 368
• HGNCID: 57
• Length: 1515
• Species: Homo sapiens
• Alignment Length: 1390
• Identity: 461/1390 - (33%)
• Similarity: 697/1390 - (50%)
• Gaps: 172/1390 - (12%)

  Fly     3 SMKADE---LPENPRERSSPL--------SSLMFCFALPVLFKGRKKTLEQKDLYRALKEHKSDS 56
            |..||:   .||:| ::|:|.        |...|.:...::::|.::.|..|||:...:|:.|:.
Human   196 SCLADQPPFFPEDP-QQSNPCPETGAAFPSKATFWWVSGLVWRGYRRPLRPKDLWSLGRENSSEE 259

  Fly    57 LGDRLCAAW--DEQVAKNETPRLG-------------------------RALTKVFG--FH-LFI 91
            |..||...|  :...|:.....:.                         |.|.|...  || .|:
Human   260 LVSRLEKEWMRNRSAARRHNKAIAFKRKGGSGMKAPETEPFLRQEGSQWRPLLKAIWQVFHSTFL 324

  Fly    92 TGVFLLAQEFLTKVTQPICLIGVMAYFAGNDPDRSKAQLWAAGLIAGSVF-SVCIGHPY----ML 151
            .|...|....:.:.|.| .|:.:...|.| ||   |...|...|:|..:| |.|:...:    |.
Human   325 LGTLSLIISDVFRFTVP-KLLSLFLEFIG-DP---KPPAWKGYLLAVLMFLSACLQTLFEQQNMY 384

  Fly   152 GLLHLGMKMRIALSSLIYRKALRLSRTALGDTTVGQVVNLLSNDVGRFDLVLINVHYLWIAPLEL 216
            .|..|.|::|.|::.|:|||.|.||..:...:.||.||||:|.||.|....::.::.||: ||..
Human   385 RLKVLQMRLRSAITGLVYRKVLALSSGSRKASAVGDVVNLVSVDVQRLTESVLYLNGLWL-PLVW 448

  Fly   217 IAV--TYLMYLEIGISSMFGVAIMLLFLPFQSYLGKRTSVLRLRTALRTDERVRMMNEIISGIQV 279
            |.|  .||..| :|.|::..:|:.|..||...::.|:.:..:.....:.|.|.|:.:.|:...:.
Human   449 IVVCFVYLWQL-LGPSALTAIAVFLSLLPLNFFISKKRNHHQEEQMRQKDSRARLTSSILRNSKT 512

  Fly   280 IKMYAWEKPFGKVVEMTRFNEMLCIKQVNYIRGILISFAMFLSRIFTSSSLIAFVLLG------- 337
            ||.:.||..|...|...|..|:..::    ..|:|.|.::...::  |:.|:|.|:..
Human   513 IKFHGWEGAFLDRVLGIRGQELGALR----TSGLLFSVSLVSFQV--STFLVALVVFAVHTLVAE 571

  Fly   338 NILNAEKAFFVTAYYNILRRSVTMFFPQGISEFAELLVSVRRLEAFMHRPETKVRDKSKVKNANQ 402
            |.:||||||......|||.:: ..|.|..|....:..||..||..|:...|.   |...|.:
Human   572 NAMNAEKAFVTLTVLNILNKA-QAFLPFSIHSLVQARVSFDRLVTFLCLEEV---DPGVVDS--- 629

  Fly   403 KAESPNGDSPKGNGIPENLIEFSQFQARWESHSLEPTLEDINLQLGRRKLVAVIGPVGAGKSSLI 467
                    |..|:...::.|........|...| .|.|..|||.:.:..|:||:||||||||||:
Human   630 --------SSSGSAAGKDCITIHSATFAWSQES-PPCLHRINLTVPQGCLLAVVGPVGAGKSSLL 685

  Fly   468 QAILGELPGESGTLRINGSYSYAAQEPWLFTGTVRQNILFGLDWDKHRYRTVVKKCALERDFELL 532
            .|:||||....|.:.|.|:.:|..||.|:...:|.:|:.||.:.|......|::.|||:.|.:..
Human   686 SALLGELSKVEGFVSIEGAVAYVPQEAWVQNTSVVENVCFGQELDPPWLERVLEACALQPDVDSF 750

  Fly   533 PFGDKTIVGERGASLSGGQKARISLARAVYRRADIYLLDDPLSAVDTHVGRHLFDQCM--RGYLR 595
            |.|..|.:||:|.:||||||.|:||||||||:|.:|||||||:|:|.|||:|:|:|.:  .|.|:
Human   751 PEGIHTSIGEQGMNLSGGQKQRLSLARAVYRKAAVYLLDDPLAALDAHVGQHVFNQVIGPGGLLQ 815

  Fly   596 SELVILVTHQLQFLEQADLIVIMDKGRISAMGTYSS-MKRSG-----LDFAQLLTAPNKDAEDLD 654
            ....|||||.|..|.|||.|:::..|.|:.||:|.. ::|.|     ||.|:   .|....|...
Human   816 GTTRILVTHALHILPQADWIIVLANGAIAEMGSYQELLQRKGALMCLLDQAR---QPGDRGEGET 877

  Fly   655 EIDGAGGD--GLDLLNVPSLSRRGSKNSKPS---TRNNSFTSL----SSMAESMAQEASLQMQET 710
            |...:..|  |......|.|.|..|..|.|.   |.:.:.|.:    ...|...|.:.|:|.
Human   878 EPGTSTKDPRGTSAGRRPELRRERSIKSVPEKDRTTSEAQTEVPLDDPDRAGWPAGKDSIQY--- 939

  Fly   711 RVEGKIGLGLYKEYLTS-GSSWFMIFFMVFLCLATQILCSAADYFLSYWVDKNVDG--QTDINTD 772
               |::...::..||.: |:.  :..:.:||.|..|:......|:||.|.|....|  ||.
Human   940 ---GRVKATVHLAYLRAVGTP--LCLYALFLFLCQQVASFCRGYWLSLWADDPAVGGQQTQ---- 995

  Fly   773 PQDMYYFAALNVAVVVFTIVRTM----LFYKMA------MRSSTQLHNAMYQGITRAAMYFFNTN 827
                   |||...  :|.::..:    ||..||      .|:|..|...:...:.|:.:.||...
Human   996 -------AALRGG--IFGLLGCLQAIGLFASMAAVLLGGARASRLLFQRLLWDVVRSPISFFERT 1051

  Fly   828 PSGRILNRFSKDLGQLDEVLPSVMLDVVQLFLTLLGIIVVICITNPYYLILTLALAIIFYYIREF 892
            |.|.:||||||:...:|..:|..:..::.....||.:.:|:.:..|...:..|.|.:::...:..
Human  1052 PIGHLLNRFSKETDTVDVDIPDKLRSLLMYAFGLLEVSLVVAVATPLATVAILPLFLLYAGFQSL 1116

  Fly   893 YLKTSRDVKRLEAVARSPIYSHLSATITGLPTIRALGAQKELIAEFDNLQDLHSSGYYTF----- 952
            |:.:|..::|||:.:.|.:.||::.|..|...:||...|...:|:  |...:..|...:|
Human  1117 YVVSSCQLRRLESASYSSVCSHMAETFQGSTVVRAFRTQAPFVAQ--NNARVDESQRISFPRLVA 1179

  Fly   953 ---LATN-RAFGYYLDCFCTLYIVIIILNYFINPPQSPGEVGLAITQAMGMTGMVQWAMRQSAEL 1013
               ||.| ...|..| .|......::...:.     |.|.||.:::.|:.:|..:||.:|...:|
Human  1180 DRWLAANVELLGNGL-VFAAATCAVLSKAHL-----SAGLVGFSVSAALQVTQTLQWVVRNWTDL 1238

  Fly  1014 ENTMTAVERVVEYDEIEPEGEFDSREGKKPS----PSWPEKGEIIAEDLCLRYFPD-PQAKYVLK 1073
            ||::.:|||:.:|.....|..:     :.|:    |.||:.|:|...|..|||.|: |.|   ::
Human  1239 ENSIVSVERMQDYAWTPKEAPW-----RLPTCAAQPPWPQGGQIEFRDFGLRYRPELPLA---VQ 1295

  Fly  1074 ALNFRIRPCEKVGIVGRTGAGKSSLINALFRL-SYNEGIITIDERDTADMGLFDLRSKISIIPQE 1137
            .::|:|...||||||||||||||||.:.|.|| ...||.|.||....|.:||..|||:||||||:
Human  1296 GVSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQEAAEGGIWIDGVPIAHVGLHTLRSRISIIPQD 1360

  Fly  1138 PVLFSGSMRYNLDPFEEYNDAKLWDALEEVKLKPLISELPNGLQSKISEGGSNFSVGQRQLVCLA 1202
            |:||.||:|.|||..:|::|..:|.|||.|:||.|::.||..||.|.::.|.:.||||:||:|||
Human  1361 PILFPGSLRMNLDLLQEHSDEAIWAALETVQLKALVASLPGQLQYKCADRGEDLSVGQKQLLCLA 1425

  Fly  1203 RAILRENRVLVMDEATANVDPQTDALIQATIRSKFRDCTVLTIAHRLNTIMDSDRVLVMDAGHLV 1267
            ||:||:.::|::|||||.|||.|:..:||.:.|.|..||||.|||||.::||..||||||.|.:.
Human  1426 RALLRKTQILILDEATAAVDPGTELQMQAMLGSWFAQCTVLLIAHRLRSVMDCARVLVMDKGQVA 1490

  Fly  1268 EFGSPYELLTSSESKIFHGMVMETG 1292
            |.|||.:||  ::..:|:.:..|:|
Human  1491 ESGSPAQLL--AQKGLFYRLAQESG 1513

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mrp4	NP_650086.2	CFTR_protein	12..1277	CDD:273530	452/1361 (33%)
		ABC_membrane	93..359	CDD:294371	84/279 (30%)
		ABCC_MRP_domain1	422..622	CDD:213217	93/201 (46%)
		ABC_membrane	735..978	CDD:294371	65/263 (25%)
		ABCC_MRP_domain2	1051..1272	CDD:213211	119/222 (54%)
ABCC6	XP_024306029.1	SunT	14..1514	CDD:331423	461/1390 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151605
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.650