Protein Alignment Mrp4 and ABCC6

DIOPT Version :10

• Sequence 1: NP_650086.2
• Gene: Mrp4 / 41387
• FlyBaseID: FBgn0263316
• Length: 1316
• Species: Drosophila melanogaster
• Sequence 2: NP_001162.5
• Gene: ABCC6 / 368
• HGNCID: 57
• Length: 1503
• Species: Homo sapiens
• Alignment Length: 1390
• Identity: 461/1390 - (33%)
• Similarity: 697/1390 - (50%)
• Gaps: 172/1390 - (12%)

  Fly     3 SMKADE---LPENPRERSSPL--------SSLMFCFALPVLFKGRKKTLEQKDLYRALKEHKSDS 56
            |..||:   .||:| ::|:|.        |...|.:...::::|.::.|..|||:...:|:.|:.
Human   184 SCLADQPPFFPEDP-QQSNPCPETGAAFPSKATFWWVSGLVWRGYRRPLRPKDLWSLGRENSSEE 247

  Fly    57 LGDRLCAAW--DEQVAKNETPRLG-------------------------RALTKVFG--FH-LFI 91
            |..||...|  :...|:.....:.                         |.|.|...  || .|:
Human   248 LVSRLEKEWMRNRSAARRHNKAIAFKRKGGSGMKAPETEPFLRQEGSQWRPLLKAIWQVFHSTFL 312

  Fly    92 TGVFLLAQEFLTKVTQPICLIGVMAYFAGNDPDRSKAQLWAAGLIAGSVF-SVCIGHPY----ML 151
            .|...|....:.:.|.| .|:.:...|.| ||   |...|...|:|..:| |.|:...:    |.
Human   313 LGTLSLIISDVFRFTVP-KLLSLFLEFIG-DP---KPPAWKGYLLAVLMFLSACLQTLFEQQNMY 372

  Fly   152 GLLHLGMKMRIALSSLIYRKALRLSRTALGDTTVGQVVNLLSNDVGRFDLVLINVHYLWIAPLEL 216
            .|..|.|::|.|::.|:|||.|.||..:...:.||.||||:|.||.|....::.::.||: ||..
Human   373 RLKVLQMRLRSAITGLVYRKVLALSSGSRKASAVGDVVNLVSVDVQRLTESVLYLNGLWL-PLVW 436

  Fly   217 IAV--TYLMYLEIGISSMFGVAIMLLFLPFQSYLGKRTSVLRLRTALRTDERVRMMNEIISGIQV 279
            |.|  .||..| :|.|::..:|:.|..||...::.|:.:..:.....:.|.|.|:.:.|:...:.
Human   437 IVVCFVYLWQL-LGPSALTAIAVFLSLLPLNFFISKKRNHHQEEQMRQKDSRARLTSSILRNSKT 500

  Fly   280 IKMYAWEKPFGKVVEMTRFNEMLCIKQVNYIRGILISFAMFLSRIFTSSSLIAFVLLG------- 337
            ||.:.||..|...|...|..|:..::    ..|:|.|.::...::  |:.|:|.|:..
Human   501 IKFHGWEGAFLDRVLGIRGQELGALR----TSGLLFSVSLVSFQV--STFLVALVVFAVHTLVAE 559

  Fly   338 NILNAEKAFFVTAYYNILRRSVTMFFPQGISEFAELLVSVRRLEAFMHRPETKVRDKSKVKNANQ 402
            |.:||||||......|||.:: ..|.|..|....:..||..||..|:...|.   |...|.:
Human   560 NAMNAEKAFVTLTVLNILNKA-QAFLPFSIHSLVQARVSFDRLVTFLCLEEV---DPGVVDS--- 617

  Fly   403 KAESPNGDSPKGNGIPENLIEFSQFQARWESHSLEPTLEDINLQLGRRKLVAVIGPVGAGKSSLI 467
                    |..|:...::.|........|...| .|.|..|||.:.:..|:||:||||||||||:
Human   618 --------SSSGSAAGKDCITIHSATFAWSQES-PPCLHRINLTVPQGCLLAVVGPVGAGKSSLL 673

  Fly   468 QAILGELPGESGTLRINGSYSYAAQEPWLFTGTVRQNILFGLDWDKHRYRTVVKKCALERDFELL 532
            .|:||||....|.:.|.|:.:|..||.|:...:|.:|:.||.:.|......|::.|||:.|.:..
Human   674 SALLGELSKVEGFVSIEGAVAYVPQEAWVQNTSVVENVCFGQELDPPWLERVLEACALQPDVDSF 738

  Fly   533 PFGDKTIVGERGASLSGGQKARISLARAVYRRADIYLLDDPLSAVDTHVGRHLFDQCM--RGYLR 595
            |.|..|.:||:|.:||||||.|:||||||||:|.:|||||||:|:|.|||:|:|:|.:  .|.|:
Human   739 PEGIHTSIGEQGMNLSGGQKQRLSLARAVYRKAAVYLLDDPLAALDAHVGQHVFNQVIGPGGLLQ 803

  Fly   596 SELVILVTHQLQFLEQADLIVIMDKGRISAMGTYSS-MKRSG-----LDFAQLLTAPNKDAEDLD 654
            ....|||||.|..|.|||.|:::..|.|:.||:|.. ::|.|     ||.|:   .|....|...
Human   804 GTTRILVTHALHILPQADWIIVLANGAIAEMGSYQELLQRKGALMCLLDQAR---QPGDRGEGET 865

  Fly   655 EIDGAGGD--GLDLLNVPSLSRRGSKNSKPS---TRNNSFTSL----SSMAESMAQEASLQMQET 710
            |...:..|  |......|.|.|..|..|.|.   |.:.:.|.:    ...|...|.:.|:|.
Human   866 EPGTSTKDPRGTSAGRRPELRRERSIKSVPEKDRTTSEAQTEVPLDDPDRAGWPAGKDSIQY--- 927

  Fly   711 RVEGKIGLGLYKEYLTS-GSSWFMIFFMVFLCLATQILCSAADYFLSYWVDKNVDG--QTDINTD 772
               |::...::..||.: |:.  :..:.:||.|..|:......|:||.|.|....|  ||.
Human   928 ---GRVKATVHLAYLRAVGTP--LCLYALFLFLCQQVASFCRGYWLSLWADDPAVGGQQTQ---- 983

  Fly   773 PQDMYYFAALNVAVVVFTIVRTM----LFYKMA------MRSSTQLHNAMYQGITRAAMYFFNTN 827
                   |||...  :|.::..:    ||..||      .|:|..|...:...:.|:.:.||...
Human   984 -------AALRGG--IFGLLGCLQAIGLFASMAAVLLGGARASRLLFQRLLWDVVRSPISFFERT 1039

  Fly   828 PSGRILNRFSKDLGQLDEVLPSVMLDVVQLFLTLLGIIVVICITNPYYLILTLALAIIFYYIREF 892
            |.|.:||||||:...:|..:|..:..::.....||.:.:|:.:..|...:..|.|.:::...:..
Human  1040 PIGHLLNRFSKETDTVDVDIPDKLRSLLMYAFGLLEVSLVVAVATPLATVAILPLFLLYAGFQSL 1104

  Fly   893 YLKTSRDVKRLEAVARSPIYSHLSATITGLPTIRALGAQKELIAEFDNLQDLHSSGYYTF----- 952
            |:.:|..::|||:.:.|.:.||::.|..|...:||...|...:|:  |...:..|...:|
Human  1105 YVVSSCQLRRLESASYSSVCSHMAETFQGSTVVRAFRTQAPFVAQ--NNARVDESQRISFPRLVA 1167

  Fly   953 ---LATN-RAFGYYLDCFCTLYIVIIILNYFINPPQSPGEVGLAITQAMGMTGMVQWAMRQSAEL 1013
               ||.| ...|..| .|......::...:.     |.|.||.:::.|:.:|..:||.:|...:|
Human  1168 DRWLAANVELLGNGL-VFAAATCAVLSKAHL-----SAGLVGFSVSAALQVTQTLQWVVRNWTDL 1226

  Fly  1014 ENTMTAVERVVEYDEIEPEGEFDSREGKKPS----PSWPEKGEIIAEDLCLRYFPD-PQAKYVLK 1073
            ||::.:|||:.:|.....|..:     :.|:    |.||:.|:|...|..|||.|: |.|   ::
Human  1227 ENSIVSVERMQDYAWTPKEAPW-----RLPTCAAQPPWPQGGQIEFRDFGLRYRPELPLA---VQ 1283

  Fly  1074 ALNFRIRPCEKVGIVGRTGAGKSSLINALFRL-SYNEGIITIDERDTADMGLFDLRSKISIIPQE 1137
            .::|:|...||||||||||||||||.:.|.|| ...||.|.||....|.:||..|||:||||||:
Human  1284 GVSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQEAAEGGIWIDGVPIAHVGLHTLRSRISIIPQD 1348

  Fly  1138 PVLFSGSMRYNLDPFEEYNDAKLWDALEEVKLKPLISELPNGLQSKISEGGSNFSVGQRQLVCLA 1202
            |:||.||:|.|||..:|::|..:|.|||.|:||.|::.||..||.|.::.|.:.||||:||:|||
Human  1349 PILFPGSLRMNLDLLQEHSDEAIWAALETVQLKALVASLPGQLQYKCADRGEDLSVGQKQLLCLA 1413

  Fly  1203 RAILRENRVLVMDEATANVDPQTDALIQATIRSKFRDCTVLTIAHRLNTIMDSDRVLVMDAGHLV 1267
            ||:||:.::|::|||||.|||.|:..:||.:.|.|..||||.|||||.::||..||||||.|.:.
Human  1414 RALLRKTQILILDEATAAVDPGTELQMQAMLGSWFAQCTVLLIAHRLRSVMDCARVLVMDKGQVA 1478

  Fly  1268 EFGSPYELLTSSESKIFHGMVMETG 1292
            |.|||.:||  ::..:|:.:..|:|
Human  1479 ESGSPAQLL--AQKGLFYRLAQESG 1501

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mrp4	NP_650086.2	MRP_assoc_pro	13..1292	CDD:188098	455/1375 (33%)
ABCC6	NP_001162.5	MRP_assoc_pro	14..1502	CDD:188098	461/1390 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	854..919		15/67 (22%)