DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mrp4 and MRP

DIOPT Version :9

Sequence 1:	NP_650086.2	Gene:	Mrp4 / 41387	FlyBaseID:	FBgn0263316	Length:	1316	Species:	Drosophila melanogaster
Sequence 2:	NP_723772.2	Gene:	MRP / 34686	FlyBaseID:	FBgn0032456	Length:	1549	Species:	Drosophila melanogaster

Alignment Length:	1398	Identity:	494/1398 - (35%)
Similarity:	745/1398 - (53%)	Gaps:	173/1398 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 ADELP----------ENPRERSSPLSSLMFCFALPVLFKGRKKTLEQKDLYRALKEHKSDSLGDR 60
            ||.:|          |.|...:|.||.:.:.:...:..||.:..||:|||:....:.....:...
  Fly   208 ADGMPRQTKYQRGENEIPELSASFLSRITYQWFDKMALKGYRNPLEEKDLWDLRPQDSCSEVMPI 272

  Fly    61 LCAAWDEQVAKN--------------------ETP---RLGR---------ALTKVFGFHLFITG 93
            ....|::.|.||                    |.|   :.||         .:.|.||      |
  Fly   273 FAHHWNQNVRKNYKNKARVEPKAQFSNGNVTFENPHGEKNGRKKGMASIMPPIYKSFG------G 331

  Fly    94 VFL---LAQEFLTKVT--QPICLIGVMAYFAGNDPDRSKAQLWAAGLIAGSVFSVCIGHPYMLG- 152
            |||   |.:.|...:|  ||..|..::::....|.:..    |...|.|..:|.:.....::||
  Fly   332 VFLFGALMKLFTDTLTFAQPQVLSLIISFVEAQDAEPE----WKGILYAVLLFVLAAAQTFILGQ 392

  Fly   153 ----LLHLGMKMRIALSSLIYRKALRLSRTALGDTTVGQVVNLLSNDVGRFDLVLINVHYLWIAP 213
                :..:|:::|.||.:.|||||||:|.:...::|||::|||::.|..||..:...::.:|.||
  Fly   393 YFHRMFIVGLRIRTALINAIYRKALRISNSTKKESTVGEIVNLMAVDAQRFMELTTYLNMIWSAP 457

  Fly   214 LELIAVTYLMYLEIGISSMFGVAIMLLFLPFQSYLGKRTSVLRLRTALRTDERVRMMNEIISGIQ 278
            |::....|.::.::|.|.:.|:|:|::.:|....:..|....::|.....||||::|||::|||:
  Fly   458 LQIGLALYFLWQQLGPSVLAGLAVMIILIPVNGVIASRIKTYQIRQMKYKDERVKLMNEVLSGIK 522

  Fly   279 VIKMYAWEKPFGKVVEMTRFNEMLCIKQVNYIRG----------ILISFAMFLSRIFTSSSLIAF 333
            |:|:||||..|.|.|...|..|:..::...|:..          .|:|...|.:.:.||.:
  Fly   523 VLKLYAWEPSFEKQVLDIRDKEIATLRSTAYLNAGTSFLWSCAPFLVSLVTFATYVLTSEA---- 583

  Fly   334 VLLGNILNAEKAFFVTAYYNILRRSVTMFFPQGISEFAELLVSVRRLEAFMHR----PETKVRDK 394
                |.|:.||.....|.:::::..:|: .|....:.||..|||.|:..|::.    |.:.:.|.
  Fly   584 ----NQLSVEKVLVSIALFDLMKLPLTI-LPMLSVDIAETQVSVNRINKFLNSEELDPNSVLHDS 643

  Fly   395 SKVKNANQKAESPNGDSPKGNGIPENLIEFSQFQARWESHSLEPTLEDINLQLGRRKLVAVIGPV 459
            ||          |:..|.: ||      |||     |..   |.||.:||:::.:..|||::|.|
  Fly   644 SK----------PHPMSIE-NG------EFS-----WGD---EITLRNINIEVKKGSLVALVGTV 683

  Fly   460 GAGKSSLIQAILGELPGESGTLRINGSYSYAAQEPWLFTGTVRQNILFGLDWDKHRYRTVVKKCA 524
            |:||||::||.|||:...:|.:...|..:|..|:.|:...|||.|||||..:|:.||..|:..||
  Fly   684 GSGKSSVVQAFLGEMEKLAGVVNTVGKLAYVPQQAWIQNATVRDNILFGQTYDRKRYNKVIDACA 748

  Fly   525 LERDFELLPFGDKTIVGERGASLSGGQKARISLARAVYRRADIYLLDDPLSAVDTHVGRHLFDQC 589
            |..|.::|..||.|.:||:|.:||||||.|||||||||..||:|||||||||||.|||:|:|::.
  Fly   749 LRADIDILSAGDLTEIGEKGINLSGGQKQRISLARAVYSDADLYLLDDPLSAVDAHVGKHIFEEV 813

  Fly   590 M--RGYLRSELVILVTHQLQFLEQADLIVIMDKGRISAMGTYSSMKRSGLDFA----QLLTAPNK 648
            :  :|.|..:..:||||.:.||.|.|.|.::..|.||..||:..:.::...||    |.|...|:
  Fly   814 IGPKGILARKSRVLVTHGVTFLPQVDSIYVIKMGEISESGTFDQLVKNKGAFADFIIQHLQEGNE 878

  Fly   649 DAEDLDEID-------------GAGGDGLDLLNVPSLSRRGSKNSKPSTRNNS-----FTSLSSM 695
            :.|:|::|.             |.....:.|....|||...|..|..|.....     .|.....
  Fly   879 EEEELNQIKRQISSTADVPELLGTVEKAIKLARTESLSDSISVTSADSLMGGGGSLRRRTKRQDS 943

  Fly   696 AESMAQEASLQMQETRVEGK-----------IGLGLYKEYLTSGSSWFMIFFMVFLCLATQIL-- 747
            .:|:|..|||:.:: .||||           :...:||.|:.|..        :||.:||.:|
  Fly   944 HDSVASAASLKKKQ-EVEGKLIETEKSQTGGVEFAVYKHYIKSVG--------IFLSVATLVLNF 999

  Fly   748 -----CSAADYFLSYWV-DKNVDGQTDINTDPQDMY--YFAALNVAVVVFTIVRTMLFYKMAMRS 804
                 ...::.:|:.|. |:||...|.:    :|||  .:.|......|......::.|....::
  Fly  1000 VFQAFQIGSNLWLTQWANDQNVANDTGL----RDMYLGVYGAFGFGQGVLAYFAVVIVYLGGFQA 1060

  Fly   805 STQLHNAMYQGITRAAM-YFFNTNPSGRILNRFSKDLGQLDEVLPSVMLDVVQLFLTLLGIIVVI 868
            :..:||.:...|.|.:: .||:..|.||:||.||.|:..:||.||:.|...:.....:|..||||
  Fly  1061 AKTIHNELLAVIIRGSVCRFFDITPIGRLLNSFSGDMDVVDEELPATMDSFMTFIFMVLATIVVI 1125

  Fly   869 CITNPYYLILTLALAIIFYYIREFYLKTSRDVKRLEAVARSPIYSHLSATITGLPTIRALGAQKE 933
            .::.|.:|.:.:.:|.::|:.:.||:.|||.:.|||:|:|||||||.|.|:||..||||......
  Fly  1126 SLSTPIFLAVIVPIAFLYYFAQRFYVATSRQLMRLESVSRSPIYSHFSETVTGASTIRAYNVGDR 1190

  Fly   934 LIAEFDNLQDLHSSGYYTFLATNRAFGYYLDCFCTLYIVIIILNYFINPPQSPGEVGLAITQAMG 998
            .|.|.|...|.:....|..:..||.....|:....|.|:...|...:....:||.|||:::.|:.
  Fly  1191 FIEESDAKVDKNQVCKYPSVIANRWLAIRLEMVGNLIILFASLFAVLGGQTNPGLVGLSVSYALQ 1255

  Fly   999 MTGMVQWAMRQSAELENTMTAVERVVEYDEIEPEGEFDSREGKKPSPSWPEKGEIIAEDLCLRYF 1063
            :|..:.|.:|.|:::|..:.:|||:.||.|.:.|..::..:.|....:||::|.:..::..:||
  Fly  1256 VTQTLNWLVRMSSDIETNIVSVERIKEYGETKQEAPWELEQDKNKPKNWPQEGRVEFQNFQVRY- 1319

  Fly  1064 PDPQAKYVLKALNFRIRPCEKVGIVGRTGAGKSSLINALFR-LSYNEGIITIDERDTADMGLFDL 1127
             ......||:.::|.|:..||||||||||||||||..|||| :....|.|:||..|.|.|||..|
  Fly  1320 -REGLDLVLRGVSFNIQGGEKVGIVGRTGAGKSSLTLALFRIIEAAGGRISIDGVDIASMGLHML 1383

  Fly  1128 RSKISIIPQEPVLFSGSMRYNLDPFEEYNDAKLWDALEEVKLKPLISELPNGLQSKISEGGSNFS 1192
            ||:::||||:|||||||:|.||||||...|.::|.|||...||..:..|..||..:|:|||.|.|
  Fly  1384 RSRLTIIPQDPVLFSGSLRINLDPFEIKTDDEIWKALELSHLKSFVKSLAAGLNHEIAEGGENLS 1448

  Fly  1193 VGQRQLVCLARAILRENRVLVMDEATANVDPQTDALIQATIRSKFRDCTVLTIAHRLNTIMDSDR 1257
            ||||||||||||:||:.:|||:|||||.||.:||.|||.|||::|::|||||||||||||:|||:
  Fly  1449 VGQRQLVCLARALLRKTKVLVLDEATAAVDLETDDLIQKTIRTEFKECTVLTIAHRLNTILDSDK 1513

  Fly  1258 VLVMDAGHLVEFGSPYELLTSSESKIFHGMVME 1290
            |:|:|.|.::||.||.|||.:.:| .|:.|..:
  Fly  1514 VIVLDKGQIIEFASPTELLDNPKS-AFYSMAKD 1545

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mrp4	NP_650086.2	CFTR_protein	12..1277	CDD:273530	486/1367 (36%)
		ABC_membrane	93..359	CDD:294371	83/285 (29%)
		ABCC_MRP_domain1	422..622	CDD:213217	96/201 (48%)
		ABC_membrane	735..978	CDD:294371	80/253 (32%)
		ABCC_MRP_domain2	1051..1272	CDD:213211	128/221 (58%)
MRP	NP_723772.2	MRP_assoc_pro	14..1548	CDD:188098	494/1398 (35%)
		ABC_membrane	338..601	CDD:279056	79/274 (29%)
		ABCC_MRP_domain1	649..848	CDD:213217	99/213 (46%)
		ABC_membrane	988..1260	CDD:279056	87/275 (32%)
		ABCC_MRP_domain2	1308..1528	CDD:213211	128/221 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45440906
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	133	1.000	Inparanoid score	I246
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	1	1.100	-	-	P	PTHR24223
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.800