DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mrp4 and CG7627

DIOPT Version :9

Sequence 1:	NP_650086.2	Gene:	Mrp4 / 41387	FlyBaseID:	FBgn0263316	Length:	1316	Species:	Drosophila melanogaster
Sequence 2:	NP_001245943.1	Gene:	CG7627 / 34148	FlyBaseID:	FBgn0032026	Length:	1355	Species:	Drosophila melanogaster

Alignment Length:	1359	Identity:	816/1359 - (60%)
Similarity:	1025/1359 - (75%)	Gaps:	68/1359 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MQSMKADELPENPRERSSPLSSLMFCFALPVLFKGRKKTLEQKDLYRALKEHKSDSLGDRLCAAW 65
            |||:|..:|||||||..:.:|:..|.:.:|...||||:||:.||||||||||||::||::|||:|
  Fly     1 MQSLKTADLPENPREHCNFISAACFWYTMPTFIKGRKRTLDTKDLYRALKEHKSETLGNKLCASW 65

  Fly    66 DEQVAKNE-TPRLGRALTKVFGFHLFITGVFLLAQEFLTKVTQPICLIGVMAYFAGNDPDRSKAQ 129
            :.::.|.: .|.|.|||.:|||::..:.|:.|...|...:..|||.|:.::||:.........|.
  Fly    66 ELELEKTKGKPNLLRALLRVFGWYFALLGLVLFLLELGLRTLQPIFLLKLIAYYTHGSESIESAY 130

  Fly   130 LWAAGLIAGSVFSVCIGHPYMLGLLHLGMKMRIALSSLIYRKALRLSRTALGDTTVGQVVNLLSN 194
            .:|||:|..|..:|.|.||||||.:|:|:|||:.:.|:|||||||||::||||||.|.||||:||
  Fly   131 YYAAGVILCSALNVIIMHPYMLGTMHVGLKMRVGMCSMIYRKALRLSKSALGDTTAGHVVNLMSN 195

  Fly   195 DVGRFDLVLINVHYLWIAPLELIAVTYLMYLEIGISSMFGVAIMLLFLPFQSYLGKRTSVLRLRT 259
            ||||.||..|.|||||:.|||.:.:|||||.||||:::||||.||||:|.|:|||||||||||||
  Fly   196 DVGRLDLATIFVHYLWVGPLETLFITYLMYREIGIAAVFGVAFMLLFIPLQAYLGKRTSVLRLRT 260

  Fly   260 ALRTDERVRMMNEIISGIQVIKMYAWEKPFGKVVEMTRFNEMLCIKQVNYIRGILISFAMFLSRI 324
            |||||||||||||||||||||||||||.||..:|...|..|:..|:.|:||||||:||.:||:|:
  Fly   261 ALRTDERVRMMNEIISGIQVIKMYAWELPFEHMVAFARKKEINAIRHVSYIRGILLSFIIFLTRV 325

  Fly   325 FTSSSLIAFVLLGNILNAEKAFFVTAYYNILRRSVTMFFPQGISEFAELLVSVRRLEAFMHRPET 389
            ....||:.:||||..|..|.||.:||||||||.::|:|||||||:.||.|||::|::.:|...||
  Fly   326 SIFLSLVGYVLLGTFLTPEVAFLITAYYNILRTTMTVFFPQGISQMAETLVSIKRVQKYMQSDET 390

  Fly   390 KVRDKS-----KVKNANQKAESPNGDSPKGNG-----------IPENL------IEFSQFQARWE 432
            .|.|.|     ..:.:||:....:||..:...           :.||.      |..|...|:|:
  Fly   391 NVMDMSVDLTEDFQGSNQETVHADGDEERDEAEDKLLGPPIATVNENAKLSEAGISISGLMAKWD 455

  Fly   433 SHSLEPTLEDINLQLGRRKLVAVIGPVGAGKSSLIQAILGELPGESGTLRINGSYSYAAQEPWLF 497
            .:|.:.:|..:||::....::.::|..|:||||||||||||||.|||.:::|||.|||:||||||
  Fly   456 VNSPDYSLNGVNLRVQPGTMLGIVGRTGSGKSSLIQAILGELPAESGEIKVNGSMSYASQEPWLF 520

  Fly   498 TGTVRQNILFGLDWDKHRYRTVVKKCALERDFELLPFGDKTIVGERGASLSGGQKARISLARAVY 562
            :||||||||||...|:.||..||||||||||||||||.|||||||||||||||||||||||||||
  Fly   521 SGTVRQNILFGQPMDRRRYAKVVKKCALERDFELLPFKDKTIVGERGASLSGGQKARISLARAVY 585

  Fly   563 RRADIYLLDDPLSAVDTHVGRHLFDQCMRGYLRSELVILVTHQLQFLEQADLIVIMDKGRISAMG 627
            |...|||||||||||||||.||||:||||||||..:|||.|||||||:.||.||||||||:||:|
  Fly   586 RETSIYLLDDPLSAVDTHVARHLFEQCMRGYLRERIVILATHQLQFLQHADQIVIMDKGRVSAVG 650

  Fly   628 TYSSMKRSGLDFAQLLTAPNKDAEDLDEIDGAGGDGLDLLNVPSLSRRGS-KNSKPSTRNNSFTS 691
            ||.|::.||||||.:|..|.:|.:..:.               |.||.|| .:|....|.||..|
  Fly   651 TYESLRESGLDFASMLADPERDEQSEER---------------SRSRSGSYTHSHSDQRRNSEQS 700

  Fly   692 LSSMAESMAQEASLQM---QETRVEGKIGLGLYKEYLTSGSSWFMIFFMVFLCLATQILCSAADY 753
            |.|||:|...:...:.   ||.:..|:|||.||.:|..:|..:|..|.|:..|:.:|.|.|..||
  Fly   701 LLSMADSCMDDLEAEQANNQERQEAGQIGLRLYSKYFKAGGGFFAFFVMMGFCVLSQGLASLGDY 765

  Fly   754 FLSYWVDK--NVDGQTDIN-------TDPQ-----------------DMYYFAALNVAVVVFTIV 792
            ||||||.|  ||..:.|.|       .:|:                 |.|.|..:.|..::.|:.
  Fly   766 FLSYWVTKKGNVAYRADNNDTTRSEELEPRLSTWLRDIGLSVDAEMLDTYIFTVITVLTILVTVA 830

  Fly   793 RTMLFYKMAMRSSTQLHNAMYQGITRAAMYFFNTNPSGRILNRFSKDLGQLDEVLPSVMLDVVQL 857
            |:.||:.:||::|.:|||:|::|||||||||||||||||||||||||:||:||:||:||:||:|:
  Fly   831 RSFLFFNLAMKASIRLHNSMFRGITRAAMYFFNTNPSGRILNRFSKDMGQVDEILPAVMMDVIQI 895

  Fly   858 FLTLLGIIVVICITNPYYLILTLALAIIFYYIREFYLKTSRDVKRLEAVARSPIYSHLSATITGL 922
            ||.|.||::||.:.||.:||.|:.|.||||.:|.|||||||||||:||:.|||:||||:|::|||
  Fly   896 FLALAGIVIVIAVVNPLFLIPTVVLGIIFYQLRTFYLKTSRDVKRMEAITRSPVYSHLAASLTGL 960

  Fly   923 PTIRALGAQKELIAEFDNLQDLHSSGYYTFLATNRAFGYYLDCFCTLYIVIIILNYFINPPQSPG 987
            .||||.|||:.|.|||||.||:|||.:|.|::|:|||||:|||||.:||.||.|::||.||.:.|
  Fly   961 STIRAFGAQRVLEAEFDNYQDMHSSAFYMFISTSRAFGYWLDCFCVIYIAIITLSFFIFPPANGG 1025

  Fly   988 EVGLAITQAMGMTGMVQWAMRQSAELENTMTAVERVVEYDEIEPEGEFDSREGKKPSPSWPEKGE 1052
            :|||||||||||||||||.||||||||||||||||||||::|||||..::...|||..||||:|:
  Fly  1026 DVGLAITQAMGMTGMVQWGMRQSAELENTMTAVERVVEYEDIEPEGALEAPADKKPPKSWPEQGK 1090

  Fly  1053 IIAEDLCLRYFPDPQAKYVLKALNFRIRPCEKVGIVGRTGAGKSSLINALFRLSYNEGIITIDER 1117
            |:.::|.|||.|||:::.|||:|:|.|:|.||||||||||||||||||||||||||:|.:.||:|
  Fly  1091 IVFDELSLRYTPDPKSENVLKSLSFVIKPKEKVGIVGRTGAGKSSLINALFRLSYNDGSVLIDKR 1155

  Fly  1118 DTADMGLFDLRSKISIIPQEPVLFSGSMRYNLDPFEEYNDAKLWDALEEVKLKPLISELPNGLQS 1182
            ||::|||.||||||||||||||||||:||||||||:||:|.|||.:|||||||.::::||:||||
  Fly  1156 DTSEMGLHDLRSKISIIPQEPVLFSGTMRYNLDPFDEYSDDKLWRSLEEVKLKEVVADLPSGLQS 1220

  Fly  1183 KISEGGSNFSVGQRQLVCLARAILRENRVLVMDEATANVDPQTDALIQATIRSKFRDCTVLTIAH 1247
            ||:|||:|||||||||||||||||||||:|||||||||||||||.|||.|||:||::||||||||
  Fly  1221 KITEGGTNFSVGQRQLVCLARAILRENRILVMDEATANVDPQTDGLIQTTIRNKFKECTVLTIAH 1285

  Fly  1248 RLNTIMDSDRVLVMDAGHLVEFGSPYELLTSSESKIFHGMVMETGQNTFDSLLKVAEKA 1306
            ||:||||||:|||||||..||||:||||||.::||:|||||.:||..|::||||:|:||
  Fly  1286 RLHTIMDSDKVLVMDAGRAVEFGTPYELLTLADSKVFHGMVKQTGHATYESLLKIAQKA 1344

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mrp4	NP_650086.2	CFTR_protein	12..1277	CDD:273530	790/1317 (60%)
		ABC_membrane	93..359	CDD:294371	161/265 (61%)
		ABCC_MRP_domain1	422..622	CDD:213217	141/199 (71%)
		ABC_membrane	735..978	CDD:294371	149/268 (56%)
		ABCC_MRP_domain2	1051..1272	CDD:213211	172/220 (78%)
CG7627	NP_001245943.1	CFTR_protein	12..1315	CDD:273530	790/1317 (60%)
		ABC_membrane	107..360	CDD:294371	158/252 (63%)
		ABCC_MRP_domain1	445..645	CDD:213217	141/199 (71%)
		ABC_membrane	815..1014	CDD:294371	127/198 (64%)
		ABCC_MRP_domain2	1089..1310	CDD:213211	172/220 (78%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45440881
Domainoid	1	1.000	179	1.000	Domainoid score	I1056
eggNOG	1	0.900	-	-		E2759_KOG0054
Homologene	1	1.000	-	-		H74563
Inparanoid	1	1.050	1131	1.000	Inparanoid score	I210
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	1	1.000	-	-		FOG0001028
OrthoInspector	1	1.000	-	-		otm26173
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	1	1.100	-	-	P	PTHR24223
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X771
	13	12.810